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Cerebral Circulation
Cerebral Circulation
Cerebral Circulation
Chhaya Saraf
Learning Issues
Arrangement of blood vessels
Unique features of cerebral circulation
Regulation of cerebral circulation
Role of intracranial tension
Blood Brain Barrier
Circle of Willis
Cerebral veins unique features (i) no valves, (ii) thinwalled, little smooth muscles, (iii) distribution does not
correspond to distribution of arteries.
Drained mainly into internal jugular vein
Cerebral circulation
Characteristic features:
Cerebral Microcirculation
4 times more capillaries in gray matter than
white matter
Relatively poor permeability due to tight
junctions
Less leaky as supported by glial feet
(Astrocytes), prevents overstretching during
high pressures
In hypertensives arterioles are usually
thickened & constricted preventing the
transmission of high pressure
Brain flow
autoregulation
Excellent between 60 and 160
mmHg
Below 60 mmHg: syncope
Above 160 mmHg: cerebral
edema
Cushings Reflex
Cerebral Stroke
Due to atherosclerosisblock in some small
arterieslocal cerebral ischemia
Hypertensives are more prone to cerebral
hemorrhage
Mostly in middle cerebral artery affects
midportion of brain
Posterior cerebral artery will affect the occipital
lobe
Midbrain involvement sensory & motor
abnormalities
Study material
Guyton 11th edition, chap. 61
Ganong 21st edition, chap. 32
Thanks