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Golongan Darah (E)
Golongan Darah (E)
Golongan Darah
darahdonor+resipien
Tidakcocoktransfusi
olehkarenaterjadiaglutinasi
Ag.
A
B
AB
Ab.
Anti A & anti B
Anti B
Anti A
-
Blood types
Agglutinogens
Agglutinins
OO
OA or AA
Anti A and
Anti B
Anti B
OB or BB
Anti A
AB
A and B
AB
Relative Frequencies
of the Different Blood Types
The prevalence of the different Blood
Sera
Anti A
Anti B
+
+
+
+
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Reaksi silang
Pentingdikerjakansebelumtransfusidarah
Eritrosit&serumantaradonor&resipiendireaksikansecara
silanginvitro
r. s. mayor : erit. donor + serum resipien ada /
tidaknya aglutinin resipien yg mungkin merusak erit.
donor
r.s.minor:serumdonor+erit.resipienada/tidaknya
aglutinindonorygmempengaruhierit.resipien.
Aglutinin donor dalam sirkulasi sangat diencerkan oleh
plasma resipien < berbahaya r.s. minor dianggap
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kurangpenting
Contoh :
DA
RB
:
:
m (+)
Ag
A
B
Ab
anti B
anti A
M (+)
antigenisitaslemah,kecualiAgDdisebut
Ag.Rh
AgRhdalameritgolonganRh(adaAg
Rh)
AgRhdalameritgolonganRh(tidakada
Rh)
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much milder
and 15 % Rh negative
Rh Blood Types
The major difference between
AOB system
Rh system
Are injected
Blood does not contain Rh factor/Rh negative
person
Anti Rh agglutinins develop slowly
Reaching maximum concentration of agglutinins
about 2 to 4 months later
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ReaksipembentukanAb.AntiRh
terpaparlagiRh
DarahtsbakandihancurkanolehAb.antiRh
14
IbuRhbayiRhkehamilanbaikolehkarenadarah
bayiplacentaibu.Waktupersalinan jaringan
placentarusakdarahbayikeibu.
imunitas ibu membentuk Ab anti Rh. Beberapa tahun
kemudian,ibuhamilII:bayiRhantiRhibukebayi
menghancurkan darah bayi anemia hemolitik
ErythroblastosisFetalis
15
Erythroblastosis Fetalis
Is a disease of the fetus and new
born child
Characterized by aglutination and
phagocytosis of the fetuss RBCs
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