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Review Protein Dan Enzim
Review Protein Dan Enzim
Group 1
Dita Luthfia
Nofita Lasari
Ranny Apriani Hapsari
Shohibatul Aslamiah
2010 Pearson Education, Inc.
Structure of Proteins
Figure 6.2b
Figure 6.3
Protein Folding
Denaturing a Protein
Figure 6.5
Hemoglobin
2 globin
subunits
2 globin
subunits
Antibody Family
A family of proteins that can be created to bind to
almost any molecule
Antibodies (immunoglobulins) are made in response to
a foreign molecule ie. bacteria, virus, pollen
called the antigen
Bind together tightly and therefore inactivates the
antigen or marks it for destruction
Antibodies
Y-shaped molecules with 2
binding sites at the upper ends
of the Y
The loops of polypeptides on the
end of the binding site are what
imparts the recognition of the
antigen
Changes in the sequence of the
loops make the antibody
recognize different antigens specificity
Antibodies
Figure 6.6
Figure 6.6
Figure 6.6
Figure 6.6
Protein Synthesis
Figure 6.8
Figure 6.7
Enzymes
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Enzymes
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Enzymes
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Enzyme-Substrate Complex
The substance
(reactant) an
enzyme acts on
is the substrate
Substrate
Joins
Enzyme
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Active Site
A restricted region of an enzyme
molecule which binds to the substrate.
Active
Site
Substrate
Enzyme
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Enzymes
Lock and Key Analogy: lock = enzyme, key
= substrate.
Induced Fit
A change in the
shape of an
enzymes active
site
Induced by the
substrate
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PROPERTIES OF ENZYME
1. As Catalyst / Biokatalisator
2. Specific
3. Its activity are affected by several
factors
4. Did not enter reacts
5. Worked two-way
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Competitive inhibitor
Enzyme
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Inhibitors
b.
Noncompetitive inhibitors:
Inhibitors that do not enter the
active site, but bind to another part
of the enzyme causing the enzyme to
change its shape, which in turn
alters the active site.
Substrate
active site
altered
Enzyme
Noncompetitive
Inhibitor
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c. Uncompetitive inhibitors:
In uncompetitive inhibition, an enzyme inhibitor
is thought to bind to the E+S structure, or both
the enzyme and the substrate together. When
this happens, the product is unable to form,
thus also inhibiting the product.
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