BIOS 220

Mendelian and Molecular

Genetics
Fall Semester 2016
Dr. Suzanne McCutcheon
Dr. Donald Morrison
Dr. David Stone
Dr. Jeremy Lynch

Lecture 1.
Genetics Revolution
Overview of genetics and the
course
Syllabus
Housekeeping details

Timeline of major advances in

genetics

Timeline of major advances in

genetics

Genomic achievements since the Human Genome Project.

ED Green et al. Nature 470, 204-213 (2011) doi:10.1038/nature09764

Scuba Rice : a case study

Fig. 1 Swarna (left) and Swarna-Sub1 (right) in a farmer's field

after 10 days of complete submergence with turbid water in Uttar
Pradesh, India. The photo was taken 27 days after the water
receded.

Rice trial video

http://www.youtube.com/watch?feature=player_detailpage&v=shCHe1eAQoQ
The contribution of submergence-tolerant (Sub1) rice varieties to food
security in flood-prone rain-fed lowland areas in Asia.
Ismail, Singh,
Singh, Dar, Mackill. 2013. Field Crops Research 152: 83 - 93

Rice Interviews ;
https://www.youtube.com/watch?v=Itgu31ncOUM

Genetics asks:
Why are children like their parents?
Why are children different from their
parents?

Gregor Mendel at
Augustinian Abbey, Brno, Bohemia

GENETICS

Mendelian Genetics (Transmission

Genetics)
(How traits are passed from one generation to
the next?)
Mendel, 1865

Molecular Genetics

Avery, 1944

GENETICS

Mendelian Genetics (Transmission

Genetics)
(How traits are passed from one generation to
the next?)
The Rules of inheritance of genes

Mendel, 1865
are Inferred from patterns observed in
gene transmission from parent to offspring
Are used, once known

To study the nature and function of

genes

To deduce individual genes properties

To predict offspring types

Molecular Genetics

Biochemical study of gene function gives a

more precise understanding of gene function Avery, 1944

Genetics: careful examination of CROSSES

Parent 1
genes
traits

n offspring:
Mating

Parent 2
genes
traits

1: genes / traits
2: genes / traits
3: genes / traits
4: genes / traits
5: genes / traits
...
n: genes / traits

Levels of Analysis

Fundamental Concepts

Central
dogma:

DNA ----> RNA ----> PROTEIN

Tools of Genetic Analysis

Mutation
Crosses
Biochemistry
Cytology
DNA Structure
DNA
manipulation

BIOS 220: MENDELIAN AND MOLECULAR GENETICS

Fall 2016: CRN 11627 and 23771
SYLLABUS
Text: Introduction to Genetic Analysis 11th Ed. By Griffiths, Wessler, Carroll & Doebley

1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.

DATE
Aug 22
Aug 24
Aug 26 F
Aug 29
Aug 31
Sept 2 F
Sept 5
Sept 7
Sept 9 F
Sept 12
Sept 14
Sept 16 F
Sept 19
Sept 21
Sept 23 F
Sept 26
Sept 28
Sept 30 F
Oct 3
Oct 5
Oct 7 F
Oct 10

TOPIC
READING*
PROBLEMS*
Cells & Genes
Ch. 1
Mendels laws
Ch. 2 & 3
2.3, 43, 44, 49; 3.12, 18, 28, 29
Mitosis and Meiosis
Ch. 2
2.17-19, 26, 27
Sex linkage & Pedigrees
Ch. 2
2.50, 53, 55, 56, 74; 3.20
Linkage and recombination Ch. 4
4.12-15, 17, 18, 32, 33
DISCUSSION 1
Homework Due (1) Ch 1-3
Labor Day Holiday
Chromosome maps
Ch. 4
4.23, 25, 30, 31, 47, 59
DISCUSSION 2
Homework Due (2) Ch 4
Multiple alleles
Ch. 6 p. 215-223
6.18,21,22,60
FLIPPED CLASS
DISCUSSION 3
(P. Set I distrib.) Homework Due (3)
Gene interaction
Ch. 6 p. 223-242
6. 14,15,17,44,65,68
FLIPPED CLASS
DISCUSSION 4
Homework Due (4)
FLIPPED CLASS
DNA structure
Ch. 7 pp. 259-274
7. 30, 31 & posted
DISCUSSION 5
Prob. Set I Due
Bacterial Genetics I
Ch.5
5. 17,31,34,4047,50
Bacterial Genetics II
Ch.5
DISCUSSION 6
Homework Due (5)
Hour Exam 1

Overview of the Course

Grading system
Examination I
Examination II
Homework 10@ 3pts
Problem Sets 2@ 20pts
Quizzes 8@ 10 pts
iClicker
50 pts
Final
200 pts
600 pts

100 pts
100 pts
30 pts
40 pts
80 pts

 Sources of information

Textbook-Introduction to Genetic Analysis 11th edition

Lectures
Discussions Fridays
Office hours
McCutcheon Monday and Wednesday 5-6 pm
TA office hours in the SLC Darwin Room

This course is best learned by doing problems

associated with the chapters

Do as many problems as you can

Work with other students
Form study groups
Go to office hours!!!

Overview of the Course

Syllabus
Monday and Wednesday-Lecture

Powerpoint slides on Blackboard

Reading Assignments
Homework Assignments
Lecture Capture

Friday Discussion
Opportunity to ask questions and work problems
Homework Due
Quizzes

BIOS 220: MENDELIAN AND MOLECULAR GENETICS

Fall 2016: CRN 11627 and 23771
SYLLABUS
Text: Introduction to Genetic Analysis 11th Ed. By Griffiths, Wessler, Carroll & Doebley

1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.

DATE
Aug 22
Aug 24
Aug 26 F
Aug 29
Aug 31
Sept 2 F
Sept 5
Sept 7
Sept 9 F
Sept 12
Sept 14
Sept 16 F
Sept 19
Sept 21
Sept 23 F
Sept 26
Sept 28
Sept 30 F
Oct 3
Oct 5
Oct 7 F

TOPIC
READING*
PROBLEMS*
Cells & Genes
Ch. 1
Mendels laws
Ch. 2 & 3
2.3, 43, 44, 49; 3.12, 18, 28, 29
Mitosis and Meiosis
Ch. 2
2.17-19, 26, 27
Sex linkage & Pedigrees
Ch. 2
2.50, 53, 55, 56, 74; 3.20
Linkage and recombination Ch. 4
4.12-15, 17, 18, 32, 33
DISCUSSION 1
Homework Due (1) Ch 1-3
Labor Day Holiday
Chromosome maps
Ch. 4
4.23, 25, 30, 31, 47, 59
DISCUSSION 2
Homework Due (2) Ch 4
Multiple alleles
Ch. 6 p. 215-223
6.18,21,22,60
FLIPPED CLASS
DISCUSSION 3
(P. Set I distrib.) Homework Due (3)
Gene interaction
Ch. 6 p. 223-242
6. 14,15,17,44,65,68
FLIPPED CLASS
DISCUSSION 4
Homework Due (4)
FLIPPED CLASS
DNA structure
Ch. 7 pp. 259-274
7. 30, 31 & posted
DISCUSSION 5
Prob. Set I Due
Bacterial Genetics I
Ch.5
5. 17,31,34,4047,50
Bacterial Genetics II
Ch.5
DISCUSSION 6
Homework Due (5)

Note:

in week 1 (only),

we have three lectures

and no Discussion sections

Overview of the Course

TA Office hours:
Science Learning Center-Darwin room
Start next week
Schedule by Friday

Dr. McCutcheon Office hour

Monday 5-6 pm
Wednesday 5-6 pm

Where are TA Office Hours held?

A LC-A1
B SCE Cafeteria
C BSB Cafeteria
D SLC Darwin
E BSB Cafeteria

Where are my Wednesday Office Office Hours held?

A LC-A1
B SCE Argo Tea
C
BSB Cafeteria
D
SLC Darwin
E
BSB Cafeteria

Where does class meet this Friday?

A
B
C
D
E

No lecture, only disc. Sections

250 BSB
Giordanos
BSB Cafeteria
SES 250

How many of your classes have used i>Clickers?

A
B
C
D
E

None
1
2 or 3
4 or 5
More than 5

BioS 220
An i>clicker remote
is required for this
course.
You can purchase it
through the
bookstore.

How will we
use the clicker?

I pose questions on the screen

during lecture.

You answer using your i>clicker

remote.

Class results are tallied.

I display a graph with the class

results on the screen.

We discuss the questions and

answers.

You get 1 point for participating

and 4 for answering correctly)!

How do you
vote?
Turn on the clicker
by pressing the
bottom On/Off
button.
A blue Power light
will appear at the
top of the remote.

How do you
vote?
When I ask a
question in class
(and start the
timer), select A, B,
C, D, or E as your
vote.

How do you know your

vote was received?
Check your Vote Status Light:
Green light = your vote was
sent AND received.
Red flashing light = you need
to vote again.
Not sure you saw the light? Just
vote again.
Want to change your vote? You can
vote again as long as the timer is
still going.

Registering your
i>clicker
You can earn points for your i>clicker
responses [for participation and/or answering
questions correctly].
Until you register your i>clicker, your
responses are tied to your clicker remote ID
(located on the back of your clicker), rather
than to you.
When you do register, your previously
recorded voting responses will be assigned to
you.

Registering
your i>clicker unit
1. Go to BlackBoard.
2. Go to Bio 220.
3. Under iClicker button or in
Tools
4. Enter your iClicker serial
number.

Other tips
If you bought a used clicker, replace the
batteries.
Register your clicker by August 23.
Before using a new clicker for the first time,
pull the plastic tab out of the battery
compartment.
Bring your clicker to class every day!
Make sure your remote is on when voting!
Check out www.iclicker.com for FAQs.
Contact support@iclicker.com for help.