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Autoimmune Diseases That Attacks The Kidneys
Autoimmune Diseases That Attacks The Kidneys
Autoimmune Diseases That Attacks The Kidneys
Etiology
primary glomerulonephritis and
secondary to infection, malignancy,
connective tissue disease (connective
tissue disease), drugs or toxins, and
due to systemic disease
Epidemiology
All age (mostly age 2-7th)
Man:woman = 2:1
Patophysiology
There antigen from outside the body
into the bloodstream bound by
antibodies forming antigenantibody complexes can not be
destroyed by macrophages and other
antigen- antibody complex
settles in the kidneys ( epithelium )
inflammation glomerulonephritis
( nephrotic syndrome )
Diagnosis
Based on clinical and laboratory
examinations in the form of massive
proteinuria > 3.5 g / 1.73 m2 body
surface area / day ) , hypoalbuminemia
< 3 g / dl , edema , hiperlipideia ,
lipiduria , and hypercoagulability
Examinations
Urinalisys
+3/+4
Therapy
Corticosteroid therapy
adult prednisone / prednisolone 1-1.5
mg / kg body weight / day for 4 8minggu
Proteinuria
ACE inhibitor
Edema
Diuretic
Prognosis
Based on the etiology. Complete remission
can occur with or without corticosteroids.
The prognosis may worsen due to
(1)an increased incidence of kidney failure
and secondary complications of SN,
including thrombotic episodes and
infections, or
(2)treatment-related conditions, such as
infection complications from giving
imunosupressive