Professional Documents
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Enzyme
Enzyme
Catherine M.
Precioso
Matching Game!
Most enzymes
are Proteins
Act as
Catalyst to
accelerate a
reaction
Not
permanently
changed in
the process
Enzymes
4
12
Enzymes work
by weakening
bonds which
lowers
activation
energy
13
Activation Energy
14
15
Enzymes
Without Enzyme
With Enzyme
Free
Energy
Products
16
17
Enzyme-Substrate Complex
18
substrate
Substrate
Joins
Enzyme
19
Active Site
Refers to the restricted
region of an enzyme
molecule
which binds to
Active
the substrate.
substrate
Site
Substrate
Enzyme
E
E
E
Enzymesubstrate
complex
Enzyme may
be used again
P
P
Reaction coordinate
2007 Paul Billiet ODWS
21
Induced Fit
23
1. Environmental
Conditions
1. Extreme Temperature
are the most dangerous
- high temps may denature
(unfold) the enzyme.
24
25
26
27
2. Cofactors and
Coenzymes
Inorganic substances
Example:
Iron must be present in
the quaternary structure
- hemoglobin in order for
it to pick up oxygen.
28
Coenzyme
29
a.
Competitive inhibitors:
Competitive inhibitor
Enzyme
Inhibitors
31
b. Noncompetitive inhibitors:
Inhibitors that do not enter the active
site,
site but bind to another part of the
enzyme causing the enzyme to
change its shape,
shape which in turn alters
the active site.
site
Substrate
active site
altered
Enzyme
Noncompetitive
Inhibitor
32
33
Components of an
Enzyme
Types of Enzymes
34
Class
Function
Transferases
Hydrolase
Catalyze hydrolysis
reactions (addition of
water molecule to a
bond)
Class
35
Lyases
Isomerase
Ligase
Function
Catalyze the addition
of a group to a double
bond or removal of a
group to create a
double bond
Catalyze the
conversion of
substrate into another
compound
36