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Depression Hypothesis - ACN
Depression Hypothesis - ACN
Depression Hypothesis - ACN
Serotonin
Dopamine
Placidity : a feeling
of calmness; a quiet
and undisturbed
feeling
obsessive or
abnormal reflection
upon an idea or
deliberation over a
choice
HETEROCYCLIC ANTIDEPRESSANT
The heterocyclic antidepressants are
postulated to work through their effects on
monoamine neurotransmitters, such as
serotonin, norepinephrine and dopamine.
These agents block the reuptake of these
neurotransmitters to varying degrees and also
interact with muscarinic, cholinergic, alpha-1adrenergic, and histaminic receptors, which
results in their characteristic side-effect profile.
Amitriptiline, Imipramine, Amoxapine
Serotonin-Norephinephrine Reuptake
Inhibitors (SNRIs): venlafaxine, duloxetine
Norephinephrine-dopamin reuptake
Inhibitors (NDRIs): Bupropoion
Growth hormone
Prolactin ???
In depression
nocturnal arousal
nocturnal awakenings
total sleep time
phasic REM sleep
core body temperature
Depressive disorder
lymphocyte proliferation in response to
mitogens
These lymphocytes produce
neuromodulators, such as corticotropinreleasing factor (CRF), and cytokines,
peptides known as interleukins.
There appears to be an association with
clinical severity, hypercortisolism, and
immune dysfunction, and the cytokine
interleukin-1 may induce gene activity for
glucocorticoid synthesis.
Depressive disorders :
abnormal hyperintensities in subcortical
regions such as periventricular regions, the
basal ganglia and the thalamus (More
common in bipolar I disorder and among the
elderly, these hyperintensities appear to
reflect the deleterious neurodegenerative
effects of recurrent affective episodes.)
The most widely replicated positron
emission tomography (PET) finding in
depression is decreased anterior brain
metabolism, which is generally more
pronounced on the left side