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Endocytosis and Cell Fate Determination: Notch Pathway
Endocytosis and Cell Fate Determination: Notch Pathway
Notch pathway
Cleavage of Notch
Kuzbaniancleave Notch ECD
green
vesicles
green
surface
shi
Ts320C
red
Shi=dynamin
vesicles
Cell 124,897
Cell 124,897,2006
1. Notch endocytosis
(Numb and -adaptin)
2. Sanpodo (required for Notch
signaling) endocytosis
3. Delta internalization to
Rab11 (+) recycling endosome
and recycle to plasma membrane