Professional Documents
Culture Documents
Natural Products Form Plants
Natural Products Form Plants
G.SUBHASRI
14UBCH040
II-BIO CHEMISTRY
Natural Products
General
Natural Products
Synthesis
Isolation
Identification
Natural Products
Natural Products
CH3
OH
H3C
HO
O
H3C
OH
OH
H3C
HO
OH
O
H3 C
CH3 H
H3C
O
OH
Digitoxin
H
H
OH
OH
CH3
O
O
CH3 H
H3C
O
OH
Digoxin
OH
Digitalis purpurea (Foxglove) and Digitalis lanata long known for their healthy heart
effects exert a positive inotropic effect on cardiac muscles treatment for heart
failure
Natural Products
OCH3
H
H
N
H
Quinidine
N
H
OH
Quinine
Natural Products
N
H H
H
O
H
MeOOC
O
OCH3
Reserpine
OCH3
OCH3
OCH3
Reserpine alkaloid from Rauwolfia serpentina plant lead from the Indian
Ayurvedic system as good for heart ... used as anti-hypertensive the plant was a
source of ~20 different alkaloids
Natural Products
OO
H
OO
O H
_
C
O
H
R
H
C
H
C
3
3C
O
O
H3 C
H3 C
H3
H3 C
H
O
R
ravastatin
M
evastatinR
R
H P
1=
2=
L
o
v
a
s
t
a
t
i
n
R
=
H
;
R
=
C
H
1
2
3
S
im1R
C
H
2=
3
fungal metabolites ... first fungal metabolite was compactin which inhibited HMGCoA reductase compactin is isolated from Penicillium citrinum, Penicillium
brevicompactin and Penicillium cyclopium ... an anti-fungal agent too, but toxic ...
Natural Products
Warfarin
CH3
*
OH
OH
OH
Dicoumarol
Natural Products
Selected Examples of Natural Product derived
Drugs
_
CH2OSO3
COO
NHSO3
O_
COO
OH
OH
OH
OH
O
OH
_
CH2OSO3
_
CH2OSO3
CH2OH
O
O
NHSO3
O_
COO
OH
O
OH
_
OSO3
O
NHCOCH3
O
OH
O
OH
_
NHSO3
10
Natural Products
Overview of Natural Products as Drugs Status in
the Period 1981-2002
500
400
300
V = vaccines
B = biologicals
NP = natural products
NPD = natural product derivatives
SNP = synthetics derived from NP
S = straight synthetics
200
100
0
NP
NPD
SNP
Compiled from :
Newman, D. J., Cragg, G. M., and Snader, K. M. (2003) NATURAL PRODUCTS AS SOURCES OF
NEW DRUGS OVER THE PERIOD 1981 2002. Journal of Natural Products 66, 1022-1037.
11
Natural Products
Natural Products
Drugs
12
Natural Products
Current Efforts
H3C
H
H CH
3
H3C
CH3
HO
OH
Trinervitane derivative
CH3
N
H3C
CH3
Me Me
Me
OH
CH3
OH
Epothilone D
13
15
HO
11 13
S
O
20