Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

DC LIU CHA
ANTHRANOID

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

MC TIU
1. c im cu trc ca 3 nhm anthranoid : Phm nhum,
nhun ty, dimer
2. Cc phng php nh tnh, nh lng anthranoid trong dc
liu
3. Phng php chit xut anthranoid t dc liu
4. Tc dng sinh hc v cng dng ca anthranoid
5. Cc dc liu cha anthranoid : Phan t dip, Cc dc liu
thuc chi Cassia VN, i hong, Cc dc liu h
Polygonaceae VN, Ba kch, L hi
DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

KHI NIM ANTHRANOID

Anthranoid l dn cht ca anthraquinon, anthrol,

anthranol, dihydroanthranol v cc dng dimer ca
chng
O

OH

O
+H2
-H2

Anthraquinon

Dng oxy ha

+H2
-H2
H

OH

+H2
-H2

Anthron

Anthranol

Dihydroanthranol

Dng kh
DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

KHI NIM ANTHRANOID

9,10 - anthracendion

O
1

8
7

10

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

ANTHRANOID NHM PHM NHUM

- C mu t cam n tm, d tan trong nc, c

dng lm phm nhum

- C 2 nhm OH k cn v tr ,
- Hay gp mt s chi thuc h Rubiaceae

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

ANTHRANOID NHM PHM NHUM

Alizarin
O

Acid carminic
OH

OH
OH

CH3

glc

COOH

HO

OH
HO

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

ANTHRANOID NHM NHUN TY

- Thng l dn cht ca 1,8 dihydroxy anthraquinon

- C3 thng c cc nhm th CH2OH, CHO, COOH,

CH3 nn cn gi l nhm oxy methyl anthraquinon
OH

OH

R
O
DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

ANTHRANOID NHM NHUN TY

OH

OH

R
O

R
CH3

Tn cht
Chrysophanol = Acid chrysophanic

CH2OH

Aloe emodin

COOH

Rhein
DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

ANTHRANOID NHM DIMER

Homodianthrol

Heterodianthron

Dirhein
HO

HO

Rheidin A
OH

OH

HO

OH

COOH

CH3

COOH

COOH

HO

OH

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

PHN B
- C trong khong 30 h thc vt khc nhau
- Lp 2 l mm
Caesalpiniaceae : Phan t dip, Tho quyt minh
Polygonaceae : H th , i hong, Ct kh c, Cht cht
Rubiaceae : Ba kch, Nhu
Rhamnaceae
- Lp 1 l mm : Rt t : L hi (Aloe vera)
- ng vt : 1 s loi su
Laccifer lacca
Coccus cacti
DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

TNH CHT
1. L tnh
- L nhng cht c mu : vng m, vng cam,
- tan : Ty thuc dng aglycon/glycosid
- Pht quang di nh sng UV
- D thng hoa

2. Ha tnh
- Tc dng vi kim to thnh mui c mu (thng mu )
- Dng oxy hoa cho mu phn ng r, dng kh cho mu khng r
DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

NH TNH ANTHRANOID
1. Phn ng Borntraeger
- nh tnh dng ton phn
Dc liu + H2SO41NAglycon + CHCl3DC CHCl3+ NaOH
10% Lp kim c mu
- nh tnh dng t do
Dc liu + Nc nng DC nc + CHCl3 DC CHCl3 +
NaOH 10% Lp kim c mu
- nh tnh acid chrysophanic (= Chrysophanol)
DC CHCl3 + NH4OH Lp kim mu , lp CHCl3 cn mu
vng + NaOH 10% Mu ca lp kim tng ln, lp
CHCl3 mt mu vng
DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

NH TNH ANTHRANOID
2. Vi thng hoa
3. Vi ha
Dc liu ct lt mng, t ln lam knh ri cho vo hp petri c NH3
c, y np, yn 10 15 pht Soi di knh hin vi : T chc
no c anthranoid s c mu vng nu
4. Sc k lp mng
Cht hp ph : Silicagel GF254
Dung mi : Ethyl acetat MeOH Nc (100 : 17 : 13)
Hin mu : Hi NH3 , Dung dch KOH/cn tuyt i. Quan st nh
sng thng hay UV
DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

NH LNG ANTHRANOID

1. Phng php cn : PP Deals v Kroeber : t dng

Dc liu + H2SO4 25% Aglycon + CHCl3 DC CHCl3 +
NaHSO3 DC CHCl3 + HCl 1% DC CHCl3 Sy, cn

2. Phng php th tch : t dng

Anthraquinon + Dd KOH 0,1N, chun KOH tha bng dd HCl 0,1.

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

NH LNG ANTHRANOID

3. Phng php o quang : PP Auterhoff

Dc liu + acid acetic Aglycon + CHCl3 DC CHCl3

+ NaOH 40% + NaOH 5% c 2% NH3 Gp cc lp
kim mu un cch thy 20 pht B sung NaOH
5% c 2% NH3 v 100ml o E

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

NH LNG ANTHRANOID

- Xy dng ng chun cobal chlorid

E

Ex

CX

C (mg/100ml)

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

NH LNG ANTHRANOID
- Tnh hm lng anthranoid theo dc liu kh tuyt i
C. v. k
X% = -------------------a. 10. (100-h)
C : Nng mg/100ml anthranoid tnh theo ng cong chun
v : Th tch ban u ca dch chit kim (ml)
a : Khi lng dc liu (g)
k : H s pha long
h : m ca dc liu (%)
DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

NH LNG ANTHRANOID

- nh lng dng t do : B qua giai on thy phn

- nh lng dng oxy ha : B qua giai on un cch
thy 20p
- nh lng dng kh : Tnh hiu s E trc v sau khi
un nng
- % dng glycosid = % dng ton phn - % dng t do

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

CHIT XUT

- Dng glycosid : Dung mi l cn EtOH, MeOH, cn

nc
- Dng aglycon : + acid, + CHCl3
- Phn lp : Sc k ct

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

TC DNG V CNG DNG

1. Kch thch tiu ha
Liu nh : B
Liu va : Nhun trng
Liu cao : Ty x
ng ung tc dng chm (sau 10 12h), ng tht tc dng
nhanh hn.
Dng kh ty mnh, tc dng ngay gy au bng
2. Acid chrysophanic : tr nm, hc lo, lang ben
3. Mt s cht chng ung th
4. Tc dng trn c trn : Khng dng cho ph n c thai
DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

DC LIU CHA
ANTHRANOID

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

PHAN T DIP
Cassia angustifolia Delile, Caesalpiniaceae

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

PHAN T DIP
Cassia acutifolia Vahl., Caesalpiniaceae

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

PHAN T DIP

L cht ca 2 loi
Cassia angustifolia Delile, Caesalpiniaceae : PTD n
C. acutifolia Vahl : PTD Alexandria (Hy lp)

Phn b : Khng c Vit nam, c ngun gc t Arp,

sau dng rt ph bin chu u

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

PHAN T DIP

Thnh phn ha hc
Anthranoid 2-3%
- Dng t do (0,05-0,1%) : Rhein, Aloe emodin,
Chrysophanol
- Dng glycosid : Senosid A,B = Dirhein anthrol
Flavonoid
Nha : gy au bng, khng tan trong nc lnh nc
ung phi lc loi nha
DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

PHAN T DIP

Tc dng v cng dng

- Nhun ty : C ngun gc t Arp, sau dng ph bin
chu u
- Tc dng trn c trn Khng dng cho PN c thai
- Qu loi ht dng nh l
- Hin nay : c trong thnh phn mt s tr gim bo
(Sene)
DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

THO QUYT MINH Cassia tora L. , Caesalpiniaceae

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

MI Cassia grandis, Caesalpiniaceae

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

MUNG TRU Cassia alata, Caesalpiniaceae

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

I HONG Rheum palmatum L., Polygonaceae

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

H TH - Fallopia multiflora (Thunb.) Haraldson

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

H TH

Thnh phn ha hc
Anthranoid
Cng dng
Y hc c truyn : B gan thn, b mu, ru tc bc sm, suy
nhc
Ch bin : Ch vi nc u en (un cch thy)

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

CT KH C - Polygonum cuspidatum Sieb. et Zucc, Polygonaceae

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

L HI

Mn : LT Dc liu 1

Aloe vera hoc Aloe ferox, Asphodelaceae

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

L HI
Aloe vera

Mn : LT Dc liu 1
Aloe ferox

DC LIU CHA ANTHRANOID

Ging vin : Nguyn Thu Hng

Mn : LT Dc liu 1

L HI
Nha l hi : dch chy ra t l ri c c, ng thnh bnh
Gel l hi : dch chy ra t l t ng li thnh gel
Thnh phn ha hc
Anthranoid : Aloe emodin, Barbaloin
Tc dng v cng dng
- Nha l hi : Nhun ty. Hin nay lm c nc gii kht, gim
bo
- Gel l hi :+ Lm lnh vt thng, vt bng
+ Chng vim
+ Lm m phm : Kem dng da, dng mi, sa tm
DC LIU CHA ANTHRANOID