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Biofisika Neuron
Biofisika Neuron
(Biophysics of Neuron)
H Aqsa Sjuhada
Building DR-G
Dept of Physiology, Airlangga University
Tel. (031) 71200 999
E-mail. draqsas@yahoo.ca
BODY LIQUID
Total : 60%
Intracellular: 40%
Extracell: 20% (kecuali cair
serebrospinal, cairan sendi, cairan
saliva)
- cairan interstitial 15%
- cairan plasma 5%
- cairan sel darah
- cairan intra vaskuler
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TRANSPORT BAHAN
PASSIVE TRANSPORT
- osmosis
- diffusion
- filtration
-solvent drag
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ACTIVE TRANSPORT
1. primary
2. secondary
- bulk transport
- exocytosis
- endocytosis
- phagocytosis
- pinocytosis
CELLULAR
ENERGY
PROCESS
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ACTIVE
TRANSPORT
required
physiology biology
PASSIVE
TRANSPORT
not required,
only kinetic
energy
physics
DIFFUSION
Particle movement
Simple diffusion : O2, CO2, alcohol
Facilitated diffusion : glucose, amine acid
OSMOSIS
Liquid movement
Hypotonic - Hypertonic
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MACAM
GERAKAN
DARI
ARAH
GERAKA
N
Osmos Solvent
is
CC SP
Tidak
Tidak
Diffusi Solut
CC +/-
Tidak
Tidak
Active Solut
Transp
CC SP
Ada
Ada
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SEL
EKSITABEL
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MEMBRAN PLASMA
STRUKTUR DAN KOMPOSISI MEMBRAN PLASMA
Lemak dynamic mozaic design / lipid bilayer 42%
Protein 55%
Karbohidrat 3%
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SIFAT
- Elastis tipis, ketebalan 6-10nm
FUNGSI
- Physical isolation
- Regulation of exchange with the
environment --- nutrition, ion
- Sensitivity --- receptor function
- Structural support
JENIS
- Impermeable
- Semi permeable
- Selective permeable
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PROTEIN
Sebagian besar glicoprotein
Protein integral / protein perifer, fungsinya:
membatasi pergerakan membran plasma
sebagai channel
carrier system
enzyme
receptor
Karbohidrat; berada di luar berikatan dg
glicoprotein maupun lipid bilayer, fungsi:
sebagai indikator sel.
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NEURO
N
= Sel saraf
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Dentrites
Cell Body
Axon
Terminal
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Basic Concepts
Volt
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Basic Concepts
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Basic Concepts
Forces that determine ionic
movement
Electrostatic forces
Concentration forces
Hydrostatic Forces
Gravity forces upon osmosis
The combination of these forces leads to dynamic
equilibrium in the cellular environment
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Besar RMP 70 mV
Artinya ?
Potensial elektriks di dalam membran sel
lebih negatif dibandingkan di luar
membran sel sebesar 70mV
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POTENSIAL MEMBRAN
Perbedaan muatan listrik di luar dan
di dalam membran sel
RMP
=Resting Membran Potential
=Potensial Membran Istirahat
Berbedaan muatan listrik di luar dan
di dalam membran sel dalam keadaan
tidak ada aktivitas elektris.
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RANGSANGAN
Adekuat
Tidak adekuat
Sumasi
27
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Action
Potential
Sequence
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Action
Potential
Sequence
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Action
Potential
Sequence
Saluran K+ menutup, terjadilah
akumulasi ion K+ di ekstrasel.
Hal ini menyebabkan
depolarisasi, sedemikian rupa
sehingga terjadi undershoot
pada akhir action potential
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Equilibrium
membran
potential
dikembalikan
33
Action
Potential
Sequence
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Refractory Period
Two types
Absolute
Relative
Membrane hyperpolarized
Some Na+ channels still refractory
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Provides resistance to AP
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