AntiAgingMedicine

olehErwinPeetosutanRSMMCJakarta
Pendahuluan:
Pertumbuhanpendudukselainkarenaangka
kelahiranmasihtinggijugakarenaangkakematian
(mortalityrate)menurun.Perubahandemografik
yangpadasaatinicenderungterusmeningkatnya
penduduksektorlanjutusia,akanmerupakan
tantanganbarudibidangpelayanankesehatanyang
akanberorientasiterhadappencegahandan
pengobatanpenyakitdegeneratif

What is Anti Aging Medicine?

AntiAgingMedicinearekeenlyloahcingfora
vagueminorsymptomscovelatedtoaging,nota
grossabruptclinicalsymptoms

IAS ( International Anti Aging)

DNA Genetic Theory

Neuroendocrine Theory
Free Radical Theory
Membrane Theory of Aging
The Hayflick Limit Theory
Mitochondrial Decline Theory
The Cross Linking Theory

A4M ( American Academy of

Anti Aging Medicine )

Wear and Tear Theory

Neuroendocrine Theory
Free Radical Theory
Genetic Control Theory
Telomerase Theory

Human Lifespan
Health Span ( active life expectancy )
Disability Span ( dependent life expectancy )

Ageisinevitable,butagingisnot
Agingprocesscanbeslowed,haltedorevenreserved

HGH has
Multiple Life Enhancing Benefits

Hypotalamus
Somastotatin

GHRH
Pituitaria
HGH = Somatotropin

GHRELIN

GEREF
Hepar
IGF-1
dan lain growth factors
Sel , Jaringan

Zombie
and
Lazarus Effect

Increase sexual potency & frequency

Higher energy levels
Improve attitude towards life
Increase resistance to common
illnesses
Increase skin elasticity
Enhanced emotional stability
Better memory

76 %
84 %
80 %
73 %

73 %
67 %
64 %

Bilamana HGH Banyak Disekresi ?

Olah Raga
Tidur
Puasa

 Growth Hormone + Testoteron > Growth

Hormone atau Testoteron
Growth Hormone + Estrogen > Growth
Hormone atau Estrogen

Sebagian besar pria tidak percaya

bahwa hormon wanita berada di
tubuhnya

Estrogen levels of the average 54

years old men is higher than
those of the average 59 years old
women

 Is it not strange that desire should so many

years outlive performance ?

W Shakespeare

Perkembangan baru HGH

GHRELIN
GEREF
HGH long acting

 Alpha 1 Antitrypsin dan Emphysema Paru

ECM = Extra Cellular Matrix

Banyak dijumpai pada

Tulang
Tulang Rawan
Kulit
Endotil Vasculer
Jaringan Paru

Perubahan Komponen ECM pada

Proses Penuaan
Post Synthetic Modification
Cell-Matrix Interaction
Fibronectin Degeneration Product
Elastin Degenaration
Elastin Peptide
Elastin Laminin

Alpha 1 Antitrypsin dan SLP 1

(secretory protease inhibitor)
tidak mampu mengimbangi
Matrix Metalloprotease (MMP)

HGH
dan Modifikasi Cell-Matrix Interaction
(Airway Remodelling)
Epitel Saluran Napas dibantu beberapa Growth
Factors, TGF Beta, IGF-1, EGF
Fibroblast
Modifikasi Komponen ECM
Elastin , Collagen , Laminin

HGH stimulasi Growth FactorsTGF ,

EGF , IGF
HGH terkait dengan proses Air-Way
Remodelling

 HGH dapat memperbaiki Faal Paru

( David Clemon )
North Carolina Medical Faculty