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ANTIASTHMATICS

ANTI-INFLAMMATORY
IMMUNOSUPPRESSIVES
DRUG
Mayramarie Lopez Flor
#RMTsoon

Antiasthmatics
Drug use for Chronic obstructive pulmonary
disease or asthma
Commonly allergic in nature

Types of Antiasthmatic Drugs


Theophylline

Albuterol

Theophylline &
Albuterol

Drug

Half-life

Therapeautic

Toxic level

Facts

Theophylline

NS: 8-9hrs
SA: 5-6hrs
C: 3-4h
Ave:8.7 hrs(non
smokers)
5.5 h(smokers)

10-20 ug/ml

>20ug/ml

Inhibits
phosphodiestera
se to maintain
high cAMP
causing
bronchodilation
Therapeutic
index is low
Metabolites
1. 1,3
dimethyluric
acid
2. 3methylxanthi
ne

Antihistamine

Steroids e.g prednisone


One of the most commonly effective against asthma

used for suppressing theimmune systemand inflammation

Anti-inflammatory drugs
1.Acetaminophen (Tylenol)
2.Acetylsalicylic acid (Aspirin)
3.Naproxem (Naprosyn)
4.Ibuprofen (Motrin)

Drug

Half-life

Therapeutic
range

Toxic level

1. Acetaminophen

2hours

5-20mg/ml

>20mg/ml

2. Acetyl-salicylic
acid

3-15 hrs

Immunosuppressives
Cyclosporin - Therapeutic range : 250-800ng/ml in whole
blood; 50-300ng/ml in plasma
Others:
Prednisone
Cyclophosphamide
Tacrolimus
Sirolimus TR: w/ cyclosporine 4-12ug/L ; discontinued
cyclospoeine 12-20ug/L
Mycophenolic Acid

-end-

GODBLESSS!!
Heart-Heart!

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