Journal Reading

Pembimbing Klinik:
dr. Eko Krisnarto, Sp. KK
Oleh:
Sela Aulia mahmudah
030.12.250

Estimating Benzathine Penicillin Need for

the Treatment of Pregnant Women
Diagnosed with Syphilis during Antenatal
Care in High- Morbidity Countries
Melanie M. Taylor1,2*, Stephen Nurse-Findlay2, Xiulei Zhang3,4, Lisa Hedman3,
Mary L. Kamb1, Nathalie Broutet2, James Kiarie2

ABSTRACT

Benzathine
penicillin for
prevention of
congenital
syphilis

Syphilis
screening
coverage
in
pregnanc
y

INTRODUCTIONS

Syphilis infection can be transmitted from mother

to infant during pregnancy resulting in con- genital
syphilis

Penicillin can prevent mother-to-child transmission

of syphilis

The World Health Organization (WHO) has

established country targets

METHODS

Selection of the 30 high syphilis burden

countries
Estimates of syphilis diagnosed during
pregnancy
Estimates of current and projected need for
benzathine penicillin for treatment of
pregnant women with syphilis

Estimated need for benzathine penicillin to

treat live-born infants of women with
syphilis
Estimates of adverse birth outcomes with
and without maternal treatment

RESULTS

Estimates of syphilis diagnosed during pregnancy among women

attending ANC and estimated current and projected need for
benzathine penicillin
Projections of penicillin need if countries were to achieve 95% syphilis
screening coverage
Estimated need for paediatric-dosed benzathine penicillin to treat live
born infants of women with syphilis
Estimates of adverse birth outcomes and those averted with maternal
treatment

DISCUSSION
Analysed ANC syphilis
surveillance data from 30 highmorbidity countries

The WHO initiative to eliminate

congenital syphilis calls for at
least 95% of pregnant women
to receive ANC

benzat
hine
penicill
in as
recom
mende
d by
WHO
WHO recommends that all infants born
to seropositive mothers receive
treatment

A single dose of benzathine penicillin

treatment received sufficiently early in
pregnancy will treat the mother and
prevent or treat congenital syphilis in
the fetus.
Of all syphilis-infected persons,
pregnant women and their infants
are the most vulnerable
Preventing infant morbidity and
mortality associated with syphilis in
pregnancy

CONCLUSION
S