Histology of Chronic Inflammation

Robbins Basic Pathology 2-20 7th Ed.

 Maturation of Monocytes into Macrophages

Robbins Basic Pathology 2-21

 Macrophage/Lymphocyte Stimulation

Adapted from Robbins Basic Pathology 2-22

 Responses to Injury

Adapted from Robbins Basic Pathology 3-16 7th Ed

 Phases of Wound Healing

Robbins Basic Pathology 3-14

Cellular Adaptation to Injury
Atrophy
Hypertrophy
Hyperplasia
Metaplasia
 Atrophy

Robbins Basic Pathology 1-4

 Hypertrophy (increase in cell size)
Uterus during pregnancy

Robbins Basic Pathology 1-3

 Hyperplasia (increase in cell number)
Thyroid Adenoma

Robbins Pathologic Basis for Disease 8-6

 Reversible vs. Irreversible Cell Injury
Reversible
Loss of ATP= cell swelling
glycolysis=lactic acid= decreased pH
decreased protein production

Irreversible
plasma membrane damage
Damaged mitochondria
damage lysosomes

Robbins Basic Pathology 1-19 7th Ed.

 Transition from Reversible to
Irreversible

Robbins Basic Pathology 1-6 7th Ed.

 Necrosis vs. Apoptosis

Necrosis

Chromatin clumping
Organelle swelling
Membrane Damage

Robbins Basic Pathology 1-6

 Necrosis vs. Apoptosis
Apoptosis

Chromatin condensation and fragmentation.

Cytoplasmic budding.
Phagocytosis of extruded apoptotic bodies.

Robbins Basic Pathology 1-12

 Apoptosis
1. Stimulus of apoptosis. (Death
ligands, lack of growth factors
or hormones, Injury).
2. Regulatory cytoplasmic
proteins. (BCL-2 family)
(Some promote some inhibit
apoptosis)
3. Execution caspases. (Activate
endonucleases and
proteinases).
4. Formation of Apoptotic Bodies.
(contain organelles and
cytosolic components).
Robbins Basic Pathology 1-23
 A N

Adapted from Robbins Basic Pathology 1-25 7th Ed.

 Next Time

Introduction to the immune system

Readings: Abbas & Lichtman, Chapter 1

 Objectives
1. Describe the pathophysiology of acute inflammation.
1. Chronology, vascular changes, cellular events, histology,
resolution.
2. Differences from chronic inflammation
2. Describe the response and the cellular adaptations to
injury.
1. Phases of wound healing
2. Atrophy, Hypertrophy, Hyperplasia, Metaplasia
3. Describe the differences between reversible and
irreversible injury.
4. Describe the differences between apoptosis and
necrosis.