Professional Documents
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Leukemia
Leukemia
Leukemia
Acute Chronic
MATURATION
Adapted and modified from U Va website
Acute Leukemia
accumulation of blasts in the marrow
How to distinguish AML vs CML
from looking at peripheral
blood
Myeloid cell CML AML normal
blasts
promyelocytes
myelocytes
metamyelocytes
bands
neutrophils
Classification of acute
leukemias
ALL AML
mainly children mainly adults
M>F M>F
curable in 70% of
children curable in minority
curable in minority of adults
of adults
Clinical manifestations
symptoms due to:
marrow failure
tissue infiltration
leukostasis
constitutional symptoms
Chemotherapy
Immunotherapy
Radiation
Bone marrow transplant
Principles of treatment
combination chemotherapy
first goal is complete remission
further Rx to prevent relapse
supportive medical care
transfusions, antibiotics, nutrition
psychosocial support
patient and family
Chemotherapy for acute
leukemias
Phases of ALL treatment
induction
consolidation post-remission therapy
Maintenance
AML treatment
induction
consolidation (post-remission therapy)
Prognosis
Adult AML
Age CR DFS
< 60 75% ~ 30%
> 60 50% 5-15%
Adult ALL