Hodgkins lymphoma

(Hodgkins disease,
Lymphogranulematosis)
Thomas Hodgkin, 1832
Berezovsky- ReedSternberg
cell
 Specific cells
The characteristic cell, the Reed-Sternberg
cell, is a bizarre, gigantic cell with more than
one large nuclei, each enclosing a large,
central, scarlet nucleolus with clear space
around it. Finding this cell is a requirement
for diagnosis in all sub-types except,
perhaps, lymphocyte predominance.
Mononuclear variants, sometimes called
Hodgkin's cells, are also characteristic of the
disease but by themselves are insufficiently
diagnostic.
 Variants of histology

(Nodular lymphocyte predominance)

nodular sclerosis
mixed cellularity
lymphocyte-rich mixed cellularity
lymphocyte depletion
 Association with infectious
mononucleosis and EBV
The association of EBV with Hodgkin's disease seems
to depend on factors such as country of residence,
histological subtype, sex, ethnicity, and age.
In particular, EBV positive Hodgkin's disease tumours
appear to be less common in developed populations,
with percentages of between 20% and 50% for North
American and European cases, 57% for Hodgkin's
disease in China, but much higher rates in
underdeveloped countries such as Peru and Kenya.
The increased incidence of EBV positive Hodgkin's
disease in underdeveloped countries could result from
the existence of an underlying immunosuppression
similar to that observed for African Burkitt's lymphoma
in a malaria infected population.
Age specific incidence
Neck lymph nodes
http://lymphoma-cancer.filefinds.net/
 Neck lymph nodes
http://bolezni-detskie.ru/zabolevaniya-sistemy-krovi/127-
limfogranulematoz-simptomy-lechenie.html
T
Chest X-ray