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Rabies Virus: An Overview of The Pathogen
Rabies Virus: An Overview of The Pathogen
RABIES VIRUS
Pathogen
Group: Lyssaviruses
Cause of zoonotic
A neurotropic virus disease: Rabies
1. Adsorption 6.
Processing
2. Penetration
7.
3. Uncoating
Replication
4.
8.Assembly
Transcription
9. Budding
5. Translation
PATHOGENESIS
,
,
Virus travels from neuromuscular
junction to peripheral nerves
,
,
PATHWAY OF VIRUS
At neuromuscular
junction
After inoculation, these glycoprotein
projections attach to the nicotinic
acetylcholine receptors of the plasma
membrane of muscle cells to enter.
flushing and washing of the wound with soap and water, detergent, providing
iodine or other substances with virucidal activity
infiltrated with either human or equine rabies immunoglobulin
Death
Medical costs 55000 death per year
lose income
economic losses (treatment and prevention)
livestock affected
Impact Of Society
Individual Impact Impact of Wildlife and Biodiversity
long term and severe side effects 20 million out of 375 million stray dogs
worldwide are slaughtered each year
reducing populations numbers.
BIBLIOGRAPHY
1. World, Health Organization. WHO Expert Consultation on Rabies, edited by Health Organization
World, World Health Organization, 2013. ProQuest Ebook Central
2. Williamson, John G.. Rabies: Symptoms, Treatment and Prevention, edited by John G.Williamson,
Nova Science Publishers, Inc., 2010. ProQuest Ebook Central
3. Okell C. N., Pinchbeck G. P., Stringer A. P., Tefera G. et al (2012) A community-based participatory
study investigating the epidemiology and effects of rabies to livestock owners in rural Ethiopia.
Prev Vet Med.
4. Claire, (4 June, 2015) Rabies Virus information,
http://rabiesvirusinformation.weebly.com/blog/rabies-virus-structure, 14 February 2017
5. Centers for Disease Control and Prevention, (April 22, 2011) The Rabies Virus,
http://https://www.cdc.gov/rabies/transmission/virus.html, 14 February 2017
6. Alfred DeMaria, Jr, MD. (2016). Clinical manifestations and diagnosis of rabies. UpToDate[online]. 1,
15. http://https://www.uptodate.com.ezp.imu.edu.my/contents/clinical-manifestations-and-
diagnosis-of-rabies/contributors.
7. Melnick, Joseph L. (2014) Rabies. AccessScience, McGraw-Hill Education[online]. 1, 3.
http://accessscience.com/content/565400