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Metastasis and Invasion
Metastasis and Invasion
Invasion
Invasion refers to the direct extension and penetration by cancer
cells into neighbouring tissues. The proliferation of transformed
cells and the progressive increase in tumour size eventually leads
to a breach in the barriers between tissues, leading to tumour
extension into adjacent tissue. Local invasion is also the first
stage in the process that leads to the development of secondary
tumours or metastases.
Steps:
Detachment of tumor cells from each other (problem in
adhesion molecules)
Degradation of extracellular matrix/basement membrane
Attachment to matrix components
Migration of tumor cells
1. Detachment of tumor cells from each other
a. Down regulation of E. cadherin expression
So tumor cells are detached from each other when adhesion molecules are not
expressed properly.
b. Mutations in genes for catenin
Under their action, tumor cells make a path between loose ECM and
migrate.
ii. Vascular Dissemination and
Homing of Tumor Cells
Intravasation of tumor cells
2. By organ tropism
Affinity of an organ for neoplastic cells
Endothelial cells of vascular beds of certain organs may express ligands for
tumor cells receptors
Some target organs may liberate chemoattractants that invite tumor cells at
that site.
Some target tissues may be unpermissive for tumor cells to grow there e.g.
skeletal muscles.
Venous spread
Due to thicker walls, some cancer tumor cells follow venous
drainage and deposit in 1st capillary bed they encounter.
Lungs and liver are the most common sites
Arterial spread
Less commonly involved due to thicker walls.