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  • Sexually Transmitted Infections (Stis) : 4Th October, 2015 1

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    ShuvashishSunuwar
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    This document discusses sexually transmitted infections and provides details about drugs used to treat herpes simplex infections. It focuses on the drug Acyclovir, describing its mechanism of action. Acyclovir is converted to its active form, Acyclovir triphosphate, within infected cells by the herpes simplex virus thymidine kinase and cellular enzymes. Acyclovir triphosphate then inhibits viral DNA synthesis by competing with deoxyGTP for viral DNA polymerase and becoming incorporated into the viral DNA as a non-functional complex, terminating the DNA chain.

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    This document discusses sexually transmitted infections and provides details about drugs used to treat herpes simplex infections. It focuses on the drug Acyclovir, describing its mechanism of action. Acyclovir is converted to its active form, Acyclovir triphosphate, within infected cells by the herpes simplex virus thymidine kinase and cellular enzymes. Acyclovir triphosphate then inhibits viral DNA synthesis by competing with deoxyGTP for viral DNA polymerase and becoming incorporated into the viral DNA as a non-functional complex, terminating the DNA chain.

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    © All Rights Reserved
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    21 views9 pages

    Sexually Transmitted Infections (Stis) : 4Th October, 2015 1

    Uploaded by

    ShuvashishSunuwar
    This document discusses sexually transmitted infections and provides details about drugs used to treat herpes simplex infections. It focuses on the drug Acyclovir, describing its mechanism of action. Acyclovir is converted to its active form, Acyclovir triphosphate, within infected cells by the herpes simplex virus thymidine kinase and cellular enzymes. Acyclovir triphosphate then inhibits viral DNA synthesis by competing with deoxyGTP for viral DNA polymerase and becoming incorporated into the viral DNA as a non-functional complex, terminating the DNA chain.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
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    of 9

    Sexually Transmitted Infections

    (STIs)

    4th October, 2015 1


    Objective

    - To list the drugs used for treatment of Herpes


    simplex infections.

    - To describe the mechanism of action of Acyclovir.

    4th October, 2015 2


    Drugs Used For Treatment of
    Herpes Simplex Infections
    Acyclovir
    Cidofovir Ganciclovir
    Docosanol Idoxuridine
    Famciclovir Penciclovir
    Foscarnet Trifluridine
    Fomivirsen Valacyclovir
    Vidarabine

    4th October, 2015 3


    Mechanism of action of
    acyclovir

    4th October, 2015 4


    Acyclovir

    viral thymidine kinase

    Acyclovir-monophosphate

    Cellular kinase

    Acyclovir-triphosphate

    4th October, 2015 5


    Acyclovir-triphosphate

    competitively inhibit incorporation into


    viral DNA polymerase viral DNA

    Non-functional complex DNA chain


    termination
    inhibits viral DNA synthesis

    4th October, 2015 6


    Mechanism of action of acyclovir
    HSV thymidine kinase:
    Facilitate cellular uptake and initial
    phosphorylation
    Cellular enzymes:
    cellular GMP kinase converts acyclovir
    monophosphate to acyclovir - diphosphate
    cellular phosphatases converts acyclovir-
    diphosphate to acyclovir - triphosphate

    4th October, 2015 7


    Acyclovir triphosphate inhibits viral DNA synthesis
    by two mechanisms:
    Competition with deoxyGTP for viral DNA
    polymerase , resulting in binding to DNA
    template as an non-functional complex
    Also incorporated into viral DNA where it acts as
    a chain terminator (because of lack of 3-hydroxyl
    group)

    4th October, 2015 8


    THANK YOU
    Any questions, queries and
    suggestions are highly welcomed.

    4th October, 2015 9

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