Anabolic Steroids

Athletes who use anabolic steroids gain

muscle mass and strength, but they also
destroy their kidney function, according to a
study by the Columbia University Medical
Centre (U.S.) which was presented at the
annual meeting of the American Society of
Nephrology in San Diego. The findings indicate
that regular steroid use has serious effects on
the kidneys which researchers were
previously unaware of.
The researchers, headed by Leal Herlitz,
carried out the first study to look at kidney
problems following long-term anabolic steroid
abuse. They studied a group of 10 body
builders who had been using steroids for
many years, and had developed a disorder in
which they were losing proteins through their
urine, along with other serious kidney
disorders.
The tests revealed that 9 out of the 10 body
builders had developed a disorder called focal
segmental glomerulosclerosis - a type of
scarring of the kidneys. The illness is usually
caused by an excessive over-working of the
kidneys.
Doping casts a dark shadow over many
different sporting competitions,
including the Olympic Games.

Perhaps the most famous case of

doping is that of Canadian sprinter Ben
Johnson, who won the 100m gold
medal in the 1988 Seoul Olympics. In
doing so he broke Carl Lewiss world
record, which until then was considered
unbeatable. However, Johnson tested
positive for the use of anabolic steroids.
He was stripped of his gold medal and
the world record, and suspended from
any form of competition for two years.
This was changed to a life suspension in
1993, when he again tested positive for
a banned substance.
Clenbuterol is an anabolic
(a substance that imitates
testosterone) which
promotes muscle growth.
For this reason it is used
by athletes to improve
their performance. The
World Anti-Doping Agency
lists it as a banned
substance, although
traces of it are often found
in foods such as beef.
Doping in Cycling
Altitude Training
Andy Schleck during stage 1 of the 2009 Tour de France.

Training at altitude may help athletes gain a competitive edge at sea level; altitude exposure also presents problems to athletes, and these could possibly cancel out benefits

Even moderate altitudes can have a significant effect on athletic performance. Click to see the effects on physical performance at altitude.
All athletes seek a competitive advantage. Although the benefits of some interventions (like training, for example) are clear, most strategies are less well-proven. Altitude is no
exception to this. Training at high altitude has been used by competitive athletes as a means of improving their performance. However, despite a good deal of research into the
subject, its true effects and a recommended approach are still not well established. Additionally, altitude training is usually expensive and fraught with logistical problems.

Benefits of Altitude Exposure

Exposure to high altitude could theoretically improve an athletes capacity to exercise. Exposing the body to high altitude causes it to acclimatise to the lower level of oxygen
available in the atmosphere. Many of the changes that occur with acclimatization improve the delivery of oxygen to the muscles -the theory being that more oxygen will lead to
better performance.
For any type of exercise lasting longer than a few minutes, the body must use oxygen to generate energy. Without it, muscles simply seize up and can become damaged. This
type of exercise is called aerobic exercise, meaning with oxygen.
The body naturally produces a hormone called erythropoietin (EPO) which stimulates the production of red blood cells, which carry oxygen to the muscles. Up to a point, the
more blood cells you have, the more oxygen you can deliver to your muscles. There are also a number of other changes that happen during acclimatization which may help
athletic performance, including an increase in the number of small blood vessels, an increase in buffering capacity (ability to manage the build up of waste acid) and changes in
the microscopic structure and function of the muscles themselves.

Problems of Altitude Exposure

However, acclimatization to high altitude is not simple, and there are a number of other
effects that could cancel out the benefits. For example the increase in red blood cells
comes at a cost - having too many blood cells makes the blood thicker and can make
blood flow sluggish. This makes it harder for your heart to pump it round the body, and can
actually decrease the amount of oxygen getting to where it is needed.
At very high altitudes (>5000m), weight loss is unavoidable because your body actually
consumes your muscles in order to provide energy. There is even a risk that the bodys
immune system will become weakened, leading to an increased risk of infections, and
there may be adverse changes in the chemical make-up of the muscles. Additionally, the
body cannot exercise as intensely at altitude. This results in reduced training intensity,
which can reduce performance in some sports. At very high altitudes, further problems are
encountered: loss of appetite, inhibition of muscle repair processes and excessive work in
breathing. On top of this, there is the problem of altitude illnesses, which can dramatically
reduce the capacity to be active at altitude, or foreshorten the exposure to high altitude
altogether.
 Blood Doping

In order to increase the volume of oxygen available, reduce fatiguing, and improve
performance, some sportspeople use transfusions of their own blood. Blood doping, as
it is called, is also a banned form of doping. It involves extracting a quantity of blood from
the athletes own body (between 20 to 30 percent of their total body blood volume) and
conserving it in a refrigerator. To enhance the benefits, it is extracted after several weeks
of high-altitude training, at at least 2000m above sea level, because of its higher
oxygenation. The body needs to be given sufficient time to replace the blood which is
removed, and restore natural levels. A couple of weeks before competition, the
competitors own blood is reinjected into their body, increasing the blood volume and
oxygenation, and making them more fatigue-resistant. Since blood is a natural substance,
it is difficult to detect this doping method, however it can be achieved through a count of
blood cells (erythrocytes). The risks involved range from contracting an illness during the
extraction, storage, and reinjection, through to thrombosis (the formation of a clot,
known as a thrombus) in a vein or artery, which impedes normal blood flow and may
even lead to a heart attack. Since blood doping is now detectable, some sportspeople
currently prefer to use synthetic erythropoietin (EPO). In its natural form, this substance
is a hormone produced by the body to stimulate the production of red blood cells and
increase blood volume. A test to detect the use of EPO was developed in 2000.
Erythropoietin, commonly known
as EPO, is a hormone which
stimulates the growth of red blood
cells, along with other effects. In
other words, it improves physical
performance by helping deliver
more oxygen to muscles.
Armstrong was categorical when he
affirmed it was impossible to win the
Tour without doping. He also said in
an interview I dont want to accuse
anyone else I made my decisions.
They are my mistake. The Texan
said that I viewed this situation as
one big lie I didnt feel as if I was
cheating, in my view, doping was
part of the job. He admits to having
taking all kinds of banned
substances: My coctail was EPO,
but not a lot, transfusions, and
testosterone.
The use of EPO or similar substances, such as recombinant
human Erythropoietin (rHuEPO), as a doping method for
improving athletic performance is prohibited. The positive
effects of EPO are due to its increasing the erythrocyte mass
(leading to an increase in the haematocrit). It improves
performance in aerobic activities, thereby increasing
endurance. According to a 2007 study, the use of rHuEPO by
healthy individuals produced a 6.4% increase in maximum
oxygen consumption (VO2 max), due primarily to a 10%
increase in haemoglobin.
MARCO PANTANI

was expelled from the 1999 Giro de Italia after high

hematocrit levels were detected in a blood sample.
Although it was not able to be proven conclusively,
this suggested that he had used EPO. From then on he
was continually subjected to accusations of doping -
accusations which he always rejected. On February
14, 2004 the climbing specialist was found dead in an
Italian hotel room, during a period in which he was
suffering from depression. The official autopsy report
eventually established that he had died from a
cocaine overdose.
 Estimulantes
Some commonly-prescribed pharmaceuticals for the treatment of colds and flu
may contain stimulants such as ephedrine, pseudoephedrine, norephedrine,
and phenylephrine. What happens if a sportsperson inadvertently takes one of
these products to treat a cold?
Stimulants

Among the drugs used by sportspeople, the most common are stimulants (mainly amphetamines)
and anabolic steroids.
Stimulants such as epinephrine, ephedrine, and norephedrine act upon the adrenal glands and
the central nervous system, increasing the heart rate, arterial pressure, muscular tension, and
nervous impulses.
The effect of stimulants on glands encourages the secretion of adrenaline, a hormone which
places the body in a state of alert. The person becomes more attentive, sleep- and fatigue-
resistant, and feels more disposed to participate in competitive activities. Stimulants also make
the symptoms of fatigue less perceptible in the central nervous system, which can lead to the user
overexerting themselves, possibly even to the point of death. Body temperature also increases
beyond that produced by normal exercise. After some time this may lead to respiratory and
cardiovascular difficulties, and even collapse.

Stimulants are used in sports requiring aggression (such as boxing and wrestling) or constantly
high effort levels (cycling, track and field), because they provoke feelings of hostility, aggression
and strength in those who use them. The secondary effects range from paranoia, insomnia and
antisocial behavior, through to addiction to other drugs such as barbiturates, which are used to
promote sleep in amphetamine users. In this way, a series of ups and downs begin which alter
cardiac rhythms and may even lead to death through the decompensation of the nervous system.
JAVIER SOTOMAYOR

The Cuban high-jumper was suspended for two years in 1999 for
cocaine use. The International Athletics Federation issued the
suspension citing exceptional circumstances after he was
awarded the silver medal in the Sydney Olympic Games with a
jump of 2.29 meters, having trained for barely over three months.
He retired at the age of 34.
Diuretics
The effect of diuretics on the human organism
specifically on the kidneys is to increase urine
excretion. This is generally achieved by increasing
the elimination of sodium chloride from the
kidneys, which is followed passively by water,
through an osmotic mechanism.

The end result of the action of these

pharmaceuticals is to increase renal salt and water
loss, producing an increased volume of urine, with
a subsequent reduction in weight.
Diuretics: Some athletes also use
diuretics to help them pass
doping tests. The increased
volume of urine dilutes the
concentration of other drugs,
making it difficult to identify their
metabolites.
Doping through Sex Change

During the 70s and 80s, the German Democratic

Republic shone brightly and emerged as a world
sporting power. At that time, sport was considered a
political tool, due largely to the representative value that
sportspeople offered their country, and especially given
the extensive media coverage of big events. However,
after winning 403 medals in international sporting
events, 151 of which were gold, the German athletes
were found to be involved in what The New York Times
described as one giant secret.
One of the most distinct cases of State Doping was that of
Shot-putter Heidi Krieger, who had to undergo sex-change
surgery due to the use of drugs, and is currently living
under the name Andreas Krieger.

She began to ingest male sex hormones from the age of 16

under orders from her trainers and doctors, as did all the
sportspeople of her generation.
The quantities of the doses she was given led to an
imbalance in her organism. Assisted by the hormones she
was ingesting, after 14 days she was capable of lifting 100
tonnes.
The Unfortunate Semenya Case
It all began during last months Athletics World Championships in Berlin,
Germany. While Usain Bolt was being praised for his records in the 100 and
200 meters, South African Caster Semenya was being recriminated for her
physical appearance: a muscular body, deep voice, and impressive race
times aroused doubts about the 18-year-old athletes gender.
 Lista de substancias prohibidas

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