DISORDERS Symptoms must interfere with important areas of functioning or cause marked distress.
Symptoms are not caused by a drug or a medical
condition.
The fears and anxieties are distinct from the symptoms of
another anxiety disorder. 1. SPECIFIC PHOBIAS A specific phobia is a disproportionate fear caused by a specific object or situation, such as fear of flying, fear of snakes, and fear of heights. Proposed DSM-5 Criteria for SPECIFIC PHOBIA 1. Marked and disproportionate fear consistently triggered by specific objects or situations
2. The object or situation is avoided or else endured with
intense anxiety
3. Symptoms persist for at least 6 months
2. SOCIAL ANXIETY DISORDER Social anxiety disorder is a persistent, unrealistically intense fear of social situations that might involve being scrutinized by, or even just exposed to, unfamiliar people. Labeled SOCIAL PHOBIA in the DSM-IV-TR Among people with social anxiety disorder, at least a third also meet the DSM IV- TR criteria for a diagnosis of avoidant personality disorder Social anxiety disorder generally begins during adolescence Proposed DSM-5 Criteria for SOCIAL ANXIETY DISORDER
1. Marked and disproportionate fear consistently triggered
by exposure to potential social scrutiny 2. Exposure to the trigger leads to intense anxiety about being evaluated negatively 3. Trigger situations are avoided or else endured with intense anxiety 4. Symptoms persist for at least 6 months. 3. PANIC DISORDER Panic disorder is characterized by frequent panic attacks that are unrelated to specific situations and by worry about having more panic attacks A panic attack is a sudden attack of intense apprehension, terror, and feelings of impending doom, accompanied by at least four other symptoms Physical symptoms can include labored breathing, heart palpitations, nausea, upset stomach, chest pain, feelings of choking and smothering, dizziness, lightheadedness, sweating, chills, heat sensations, and trembling. Depersonalization; derealization Fears of losing control, of going crazy, or even of dying. Among those who develop panic disorder, the onset is typically in adolescence Proposed DSM-5 Criteria for PANIC DISORDER 1. Recurrent uncued panic attacks
2. At least 1 month of concern about the possibility of
more attacks, worry about the consequences of an attack, or maladaptive behavioral changes because of the attacks 4. AGORAPHOBIA Agoraphobia (from the Greek agora, meaning marketplace) is defined by anxiety about situations in which it would be embarrassing or difficult to escape if anxiety symptoms occurred Proposed DSM-5 Criteria for AGORAPHOBIA 1. Disproportionate and marked fear or anxiety about at least 2 situations where it would be difficult to escape or receive help in the event of incapacitation or panic- like symptoms, such as being outside of the home alone; traveling on public transportation; being in open spaces such as parking lots and marketplaces; being in shops, theaters, or cinemas; or standing in line or being in a crowd 2. These situations consistently provoke fear or anxiety 3. These situations are avoided, require the presence of a companion, or are endured with intense fear or anxiety 4. Symptoms last at least 6 months 5. GENERALIZED ANXIETY DISORDER
People with GAD are persistently worried, often about
minor things.
The term worry refers to the cognitive tendency to chew
on a problem and to be unable to let go of it
GAD typically begins in adolescence
Proposed DSM-5 Criteria for GENERALIZED ANXIETY DISORDER 1. Excessive anxiety and worry at least 50 percent of days about at least two life domains (e.g., family, health, finances, work, and school) 2. The worry is sustained for at least 3 months 3. The anxiety and worry are associated with at least three of the following: restlessness or feeling keyed up or on edge being easily fatigued difficulty concentrating or mind going blank irritability muscle tension sleep disturbance The anxiety and worry are associated with marked avoidance of situations in which negative outcomes could occur, marked time and effort preparing for situations that might have a negative outcome, marked procrastination, difficulty making decisions due to worries, or repeatedly seeking reassurance due to worries COMORBIDITY IN ANXIETY DISORDERS Beyond high rates of diagnosable anxiety disorders, it is very common for people with one anxiety disorder to report subthreshold symptoms (symptoms that do not meet full diagnostic criteria) of other anxiety disorders
Comorbidity within anxiety disorders arises for two primary
reasons: 1. The symptoms used to diagnose the various anxiety disorders overlap; for example, social anxiety and agoraphobia might both involve a fear of crowds 2. Some etiological factors, like certain neurobiological or personality characteristics, may increase risk for more than one anxiety disorder COMORBIDITY IN ANXIETY DISORDERS
More specifically, about 60 percent of people in treatment
for anxiety disorders meet the diagnostic criteria for major depression
Other conditions commonly comorbid with anxiety
disorders include substance abuse and personality disorders, medical disorders (heart disease) GENDER AND SOCIOCULTURAL FACTORS IN THE ANXIETY DISORDERS GENDER Several studies suggest that women are at least twice as likely as men to be diagnosed with an anxiety disorder CULTURE In Japan a syndrome called taijin kyofusho involves fear of displeasing or embarrassing others; people with this syndrome typically fear such things as making direct eye contact, blushing, having body odor, or having a bodily deformity. Kayak-angst, a disorder that is similar to panic disorder, occurs among the Inuit people of western Greenland; seal hunters who are alone at sea may experience intense fear, disorientation, and concerns about drowning GENDER AND SOCIOCULTURAL FACTORS IN THE ANXIETY DISORDERS CULTURE koro (a sudden fear that ones genitals will recede into the bodyreported in southern and eastern Asia), shenkui (intense anxiety and somatic symptoms attributed to the loss of semen, as through masturbation or excessive sexual activityreported in China and similar to other syndromes reported in India and Sri Lanka), and susto (fright-illness, the belief that a severe fright has caused the soul to leave the bodyreported in Latin America and among Latinos in the United States) Cambodian refugees, very elevated rates of panic disorder (often diagnosed traditionally as kyol goeu, or wind overload) COMMON RISK FACTORS ACROSS THE ANXIETY DISORDERS 1. Behavioral conditioning (classical and operant conditioning) 2. Genetic vulnerability 3. Increased activity in the fear circuit of the brain 4. Decreased functioning of GABA and serotonin; increased norepinephrine activity 5. Behavioral inhibition 6. Neuroticism 7. Cognitive factors, including sustained negative beliefs, perceived lack of control, and attention to cues of threat COMMON RISK FACTORS ACROSS THE ANXIETY DISORDERS FEAR CONDITIONING Behavioral theory of anxiety disorders focuses on conditioning. Mowrers two-factor model of anxiety disorders, published in 1947, continues to influence thinking in this area 1. Through classical conditioning, a person learns to fear a neutral stimulus (the CS) that is paired with an intrinsically aversive stimulus (the UCS). 2. Through operant conditioning, a person gains relief by avoiding the CS. This avoidant response is maintained because it is reinforcing (it reduces fear) COMMON RISK FACTORS ACROSS THE ANXIETY DISORDERS NEUROBIOLOGICAL FACTORS:THE FEAR CIRCUIT AND THE ACTIVITY OF NEUROTRANSMITTERS A set of brain structures called the fear circuit tend to be involved when people are feeling anxious or fearful Elevated activity in the fear circuit, particularly the amygdala, may help explain many different anxiety disorders The medial prefrontal cortex appears to be important in helping to regulate amygdala activityit is involved in extinguishing fears as well as using emotion regulation strategies to control emotions COMMON RISK FACTORS ACROSS THE ANXIETY DISORDERS PERSONALITY: BEHAVIORAL INHIBITION AND NEUROTICISM behavioral inhibition, a tendency to become agitated and cry when faced with novel toys, people, or other stimuli Neuroticism is a personality trait defined by the tendency to react to events with greaterthan- average negative affect COGNITIVE FACTORS focus on three: sustained negative beliefs about the future, a perceived lack of control, and attention to signs of threat ETIOLOGY OF ANXIETY DISORDERS Anxiety disorders also appear to involve poor functioning of the GABA and serotonin systems as well as high norepinephrine levels. Specific phobias are believed to reflect conditioning in response to a traumatic event. Social anxiety disorder appears related to conditioning and behavioral inhibition Neurobiological research demonstrates that panic attacks are related to high activity in the locus ceruleus. Behavioral models emphasize the possibility that people could become classically conditioned to experience panic attacks in response to external situations or internal somatic signs of arousal. Conditioning to somatic signs is called interoceptive conditioning. Cognitive perspectives focus on catastrophic misinterpretations of somatic symptoms ETIOLOGY OF ANXIETY DISORDERS
A cognitive model of agoraphobia focuses on fear of
fear, or overly negative beliefs about what will happen if one experiences anxiety. Generalized anxiety disorder (GAD) has been related to deficits in the GABA system. One cognitive model emphasizes that worry might actually protect people from intensely disturbing emotional images. People with GAD also appear to be intolerant of ambiguity TREATMENTS OF THE ANXIETY DISORDERS Effective psychological treatments for anxiety disorders share a common focus: exposure that is, the person must face what he or she deems too terrifying to face. Systematic desensitization was the first widely used exposure treatment (Wolpe, 1958). The effects of CBT appear to endure when follow-up assessments are conducted 6 months after treatment Virtual reality is sometimes used to simulate feared situations such as flying, heights, and even social interactions TREATMENTS OF THE ANXIETY DISORDERS PSYCHOLOGICAL TREATMENT OF PHOBIAS Many different types of exposure treatments have been developed for phobias. Exposure treatments often include in vivo (real-life) exposure to feared objects. Systematic desensitization is effective in vivo exposure is more effective than systematic desensitization PSYCHOLOGICAL TREATMENT OF SOCIAL ANXIETY DISORDER David Clark (1997) has developed a version of cognitive therapy for social anxiety disorder that expands on other treatments in a couple of ways. TREATMENTS OF THE ANXIETY DISORDERS PSYCHOLOGICAL TREATMENT OF PANIC DISORDER A psychodynamic treatment for panic disorder has been developed. The treatment involves 24 sessions focused on identifying the emotions and meanings surrounding panic attacks. One well-validated cognitive behavioral treatment approach called panic control therapy (PCT) is based on the tendency of people with panic disorder to overreact to the bodily sensations PSYCHOLOGICAL TREATMENT OF AGORAPHOBIA Cognitive behavioral treatments of agoraphobia also focus on exposurespecifically, on systematic exposure to feared situations TREATMENTS OF THE ANXIETY DISORDERS PSYCHOLOGICAL TREATMENT OF GENERALIZED ANXIETY DISORDER The most widely used behavioral technique involves relaxation training to promote calmness Relaxation techniques can involve relaxing muscle groups one-by-one or generating calming mental images. MEDICATIONS THAT REDUCE ANXIETY Drugs that reduce anxiety are referred to as sedatives, minor tranquilizers, or anxiolytics (the suffix -lytic comes from a Greek word meaning to loosen or dissolve). Two types of medications are most commonly used for the treatment of anxiety disorders: benzodiazepines (e.g., Valium and Xanax) and antidepressants, including tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), and a newer class of agents called serotoninnorepinephrine reuptake inhibitors (SNRIs D-cycloserine (DCS), though, is a different type of drug, one that enhances learning PSYCHOLOGICAL TREATMENT FOR THE ANXIETY DISORDERS Behavior therapists focus on exposure to what is feared. Systematic desensitization and modeling may be used as parts of exposure therapy. For some anxiety disorders, cognitive components may also be helpful in therapy. Exposure treatment for specific phobias tends to work quickly and well. Adding cognitive components to exposure treatment may help for social anxiety disorder Treatment for panic disorder often involves exposure to physiological changes Treatment for agoraphobia may be enhanced by including partners in the treatment process Relaxation and cognitive behavioral approaches are helpful for GAD. 1. fear - an emotional response to immediate danger 2. anxiety - a state of apprehension often accompanied by mild autonomic arousal 3. worry - thinking about potential problems, often without settling on a solution 4. phobia - an excessive fear of a specific object or situation that causes distress or impairment 5. GAD is defined by: a. worry 6. A person with one anxiety disorder has about a percent chance of developing a second disorder and about a percent chance of developing major depressive disorder. c. 75, 60 7. The odds that a person will develop an anxiety disorder sometime during his or her lifetime are at least: c. 1 in 4
1. Research suggests that genes can explain percent of
the variance in anxiety disorders other than panic disorder b. 2040 percent 2. is a personality trait characterized by a tendency to react to events with intense negative affect. c. Neuroticism 3. Cognitive factors found to correlate with anxiety disorders include: d. lack of perceived control 4. A key structure in the fear circuit is the: b. amygdala 5. Panic disorder - anxiety sensitivity 6. GAD- avoidance of powerful negative emotions 7. Specific phobias - prepared learning 8. The first step in Mowrers two-factor model includes conditioning, and the second step involves conditioning. c. classical, operant FALSE 1. Anxiolytic medications work better than CBT. TRUE 2. Anxiety symptoms often return when a person stops taking anxiolytic medications. FALSE 3. Antidepressants are addictive. FALSE 4. Side effects are no longer a concern with modern anxiolytics. 5. Which of the following are valid treatment approaches to anxiety disorders? b. benzodiazepines c. antidepressants d. exposure 6. D-cycloserine: c. bolsters the effects of exposure treatment
(Advances in Experimental Medicine and Biology 746) Tomotoshi Marumoto, Hideyuki Saya (Auth.), Ryuya Yamanaka MD, PHD (Eds.) - Glioma - Immunotherapeutic Approaches-Springer-Verlag New York (2012)