CYSTIC FIBROSIS *

PANCREAS
Deevon M. Cariaga
FEU-NRMF Medicine
 Case:
A 10 year old male patient was found to have cystic fibrosis. Recently, he was
brought to a medical institution because of (-) pancreatic lipase
for 2 months, with noticeable voluminous foul smelling stools. P.E.
findings include distended abdomen and rectal prolapse. Laparotomy
with biopsy of pancreas was done.
 Etiology
autosomal recessive disease
defects in the CFTR gene on chromosome 7q31.2
Aka Mucoviscodosis
D/O of ion transport in cell (Abnormal function of epithelial lining of
certain parts of the body.
 Pathogenesis

Ineffective Cl
Channels, Thick and
preventing them sticky mucus Persistent
Produces thick (-) pancreatic diarrhea, foul Rectal prolapse
from regulating clogs ducts of
and sticky mucus lipase smelling stool
the flow of Cl ions airway and
and H20 across glands
Mutations in membranes

gene encoding
CFTR
 Morphology
GROSS MICROSCOPIC
 Clinical Manifestations
voluminous foul smelling stools
distended abdomen
rectal prolapse