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  • Biochem

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    Concepcion R. Aquino
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    Dolichol is essential for glycoprotein synthesis. It is formed from farnesyl diphosphate through the addition of 16 isopentyl diphosphate residues. Dolichol phosphate acts as an intermediate to transfer oligosaccharide chains to proteins, with the chains being built up through the sequential addition of sugars such as glucose, mannose, and galactose by transferase enzymes using UDP-sugar donors.

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    Dolichol is essential for glycoprotein synthesis. It is formed from farnesyl diphosphate through the addition of 16 isopentyl diphosphate residues. Dolichol phosphate acts as an intermediate to transfer oligosaccharide chains to proteins, with the chains being built up through the sequential addition of sugars such as glucose, mannose, and galactose by transferase enzymes using UDP-sugar donors.

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    3 views6 pages

    Biochem

    Uploaded by

    Concepcion R. Aquino
    Dolichol is essential for glycoprotein synthesis. It is formed from farnesyl diphosphate through the addition of 16 isopentyl diphosphate residues. Dolichol phosphate acts as an intermediate to transfer oligosaccharide chains to proteins, with the chains being built up through the sequential addition of sugars such as glucose, mannose, and galactose by transferase enzymes using UDP-sugar donors.

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    of 6

    GLYCOPROTEIN SYNTHESIS

    DOLICHOL
    Essential for the synthesis of glycoprotein
    Formed from farnesyl dihosphate by further addition of 16 isopentyl diphosphate
    residues

    DOLICHOL
    SYNTHESIS OF DOLICHOL FROM FARNESYL
    GLYOPROTEIN SYNTHESIS USING DOLICHOL PHOSPHATE AS INTERMEDIATE
    UDP-Glucose UDP

    UMP Dol-P-P-Glu Dol-P-P-Glu-Glu GDP-Mannose


    Transferase
    UDP-Glucose Transferase Transferase
    GMP
    Dolichol phosphate Dol-P-P-Glu-Glu-Man

    UDP-Galactose
    Transferase

    Man-Gal-Man-Glu-Glu-P-P-HN-C=O-CH2-(protein) Dolichol pyrophosphate Dol-P-P-Glu-Glu-Man-Gal

    Oligosacchaaryl Transferase
    Transferase
    GDP-Mannose
    Dol-P-P-Glu-Glu-Man-Gal-Man
    H2N-C=O-H2C-(protein)

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