Improved Survival Among Icu-Hospitalized Patients With Community-Acquired Pneumonia by Unidentified Organisms: A Multicenter Case-Control Study

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Journal Reading

IMPROVED SURVIVAL AMONG ICU-HOSPITALIZED


PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA BY
UNIDENTIFIED ORGANISMS:
a multicenter case-control study
J. Rello1,2 & E. Diaz2,3 & R. Maez4 & J. Sole-Violan2,5 & J. Valles2,6 & L. Vidaur2,7 &
R. Zaragoza8 & S. Gattarello9 & CAPUCI II Consortium

SIGIT ANANDA
1407101030284

dr. HERRY PRIYANTO, Sp.P(K)

BAGIAN/ SMF PULMONOLOGI FAKULTAS KEDOKTERAN


UNIVERSITAS SYIAH KUALA/ RSUD dr. ZAINOEL ABIDIN BANDA ACEH
2017
Introduction
Community
Acquired
Pneumonia

Mortality and
Social cost
morbidity

Better
Early outcome?
antibiotic
Severe CAP &
Antibiotic
combination
Worst
Objective

Primary Objective
The primary objective of the present study was to
compare mortality between two cohorts of patients
diagnosed with severe CAP in different time periods
and admitted to the intensive care unit (ICU).

Secondary Objective
The secondary objective was to determine whether
changes in antibiotic policies were associated with
different outcomes.
Material and Methods
The CAPUCI I33 hospitals
from 2000 to 2002 (n=529)
Prospective The CAPUCI II 2008-2015
Cohort (n=616)

Inclusion criteria
CAPUCI 1
Severe CAP was defined as pneumonia that required ICU admission
following Infectious Diseases Society of America/American Thoracic
Society (IDSA/ATS) indications

Exclusion criteria
CAPUCI II
Patients with severe chronic illness in whom pneumonia was an
expected terminal event (do not resuscitate or intubate orders)
Patients diagnosed with healthcareassociated pneumonia or with a
no-cardiopulmonary resuscitation indication
Immune compromise

Demographic data and


clinical presentation,
outcome, and antibiotic
therapy
Material and Methods
Result
Result
Result
Result
Result
Conclusion

Our findings confirm that, over the past 15 years,


survival for community-acquired pneumonia
(CAP) in the intensive care unit (ICU) has
improved in all subsets, like in sepsis, myocardial
infarction, or stroke. Better implementation of the
recommendations in the guidelines has been
associated with improved survival in a condition
that remains a management challenge, being
the first cause of sepsis in general ICUs.
Thank You

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