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Gonado
Gonado
Gonadotropins
Gonadotropins are hormones produced by the pituitary
gland that act on the gonads (the sexual organs) i.e. Ovaries
& Testes to effect various endocrine functions.
Preparations Main
Gonadotropins
available Complications:
Human Conventional
Menopausal OHSS
Gonadotropin GTs
Follicle Highly Multiple
Stimulating Purified GTs
Hormone
Recombinant pregnancies
Human Chorionic
Gonadotropin GTs
Human Menopausal Gonadotropin
Menotropins are extracted from the urine of postmenopausal
women
Options Available:
GnRH Agonists
GnRH Antagonists
GnRH Agonists
Prevents premature LH surge
Used:
as adjunctive therapy in order to enhance induction
of ovulation with HMG, especially for IVF
For the treatment of endometriosis and fibroids.
Available Molecules:
Leuprolide Acetate
Burseriln Acetate
Goserilin Acetate
GnRH Antagonists
For the inhibition of premature LH surge in women undergoing
controlled ovarian stimulation
Causes pituitary down regulation by receptor competition
Available Molecules:
Cetrorelix
Ganirelix
Infertile Patient Treatment Flow
IVF- IN Vitro
IUI- Intra Uterine
Gynaec Insemination
Fertilization
-IVF is simply uniting the egg &
- Treated with 4-5 cycles -If there is tubal blockage then sperm in vitro ( Lab )
with clomiphene citrate , if directly sent for IVF or ICSI
-Subsequently the embryos are
failed then send to IUI - Or else 5-6 max cycles of IUI transferred to uterus through
cyles are tried before sending to cervix
IVF
IVF MARKET MAPPING
TOTAL NO OF IVF :- 540
0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2
1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8
USG USG
Choice of Gonadotropins
39%
38% Recombinant
IVF
Highly Purified
Conventional
23%
10%
Recombinant
IUI 30%
Highly Purified
60% Conventional
Sales scenario
Ach -206.24
% Ach - 174
Ach 648.63
% Ach 328
Ach -109.01
% Ach -64
Ach 38.28
% Ach - 84
20 booklets /ME
BHARAT
ENDOPROST Feb-05 SERUMS & 14.7 14.6 55.3% (0)
VACCINES LTD
ASTRAZENECA
PROSTODIN Mar-90 PHARMA INDIA 5.8 9.3 35.1% 61
LTD
NEON
CABOPROST Dec-07 LABORATORIES 2.3 1.4 5.3% (40)
LTD
DR. REDDYS
DEVIPROST Jul-00 LABORATORIES 0.3 0.0 0.0% (98)
LTD
All India Scenario: Femiprost
MEYER
PPH Jul-10 ORGANICS 1.8 2.4 55.9% 33
PVT. LTD
ZYDUS
CERVISURE Jan-13 0.0 0.1 3.2% 291
CADILA
All India Scenario- Cervisure