GONORRHEA

Fakhri Mubarok 151021033

 Semua penyakit infeksi yg disebabkan o/ Neisseria
gonorrhea (genito-genital, oro-genital, ano-genital)
ETIOLOGI

Neisseria gonorrhoeae kuman

kokus Gram (-), ukuran 0.6-1.5
um; diplokokus
Terlihat di luar & di dlm leukosit
Tdk tahan lama di udara bebas
Tdk motil; (-) spora
Cepat mati dlm kead kering
Tdk tahan suhu >39C & desinfektan

Daerah yg paling mdh terinfeksi :

daerah dgn mukosa epitel kuboid/lapis
gepeng yg blm berkembang
MORFOLOGI

Membran sitoplasma
Lapisan peptidoglikan
Dinding sel
Lap polisakarida
Pili
Protein
Porin protein
Opa
RMP
Lipooligosakarida
Ig A1 protease
EPIDEMIOLOGI
Insidensi tinggi; tersebar di seluruh dunia scr
endemik
Di AS : 400.000-1 jt/th

20-24 tahun 15-19 tahun

Differences Between Men & Women
with Gonorrhea
IN MEN:
Urethritis; Epididymitis
Most infections among men are acute and symptomatic with purulent
discharge & dysuria (painful urination) after 2-5 day incubation period
The two bacterial agents primarily responsible for urethritis among men
are N. gonorrhoeae and Chlamydia trachomatis

IN WOMEN:
Cervicitis; Vaginitis; Pelvic Inflammatory Disease (PID)
Women often asymptomatic or have atypical indications.serious
complication in case of untreated infection ranging from PID
complications to infertility
Pelvic Inflammatory Disease (PID) May also be asymptomatic, but
difficult diagnosis accounts for many false negatives Can cause
irreversible damage (scarring ) of fallopian tubes leading to infertility
or ectopic pregnancy (egg trapped in fallopian tube and fetus begin to
develop here)
GEJALA KLINIS
Uretritis
>> uretritis anterior akuta
Gx;
Rasa gatal & panas di bag
distal rethra sekitar OUE
Disuria
Polaksiuria
Keluar duh mukopurulen dr
OUE, kdg disertai darah &
nyeri saat ereksi
PF : OUE hiperemis, edema,
ektropion
 Tysonitis
Parauretritis
Littritis
Cowperitis
Prostatitis
Rasa tdk nyaman di daerah
perineum & suprapubis
Malaise-demam
Disuria
Hematuria
Spasme otot urethra
Retensi urin
Vesikulitis
Vas deferenitis/funikulitis
Epididimitis
Trigonitis
 Uretritis
Gx : disuria, kdg poliuria
PF : OUE merah,
edematosa, & ditemukan
sekret mukopurulen
 Parauretritis/skenitis Infeksi non genital
Servisitis Proktitis
Dpt asimptomatis nyeri pd Orofaringitis
punggung bwh Konjungtivitis
Bartholinitis Genitalia
Salpingitis diseminata
DIAGNOSIS
Px penunjang
Sediaan langsung
Gonokok Gram (-) intraseluler &
ekstraseluler
Kultur
Media transpor
Media transpor media Stuart,
media Transgrow
Media pertumbuhan Mc Leods
chocolate agar, media Thayer
Martin, modified Thayer Martin
agar
Tes identifikasi presumtif &
konfirmasi (definitif)
Tes oksidase
Tes fermentasi
Tes beta laktamase
 Tes Thomson
 Uji serologis (70%)
Px antibodi thd N. Gonorrhoeae spt
Fiksasikomplemen
Imunopresipitasi
Imunofloresensi
ELISA

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