Professional Documents
Culture Documents
Management of Asthma: Alsalman A. Anam Gullas College of Medicine
Management of Asthma: Alsalman A. Anam Gullas College of Medicine
Management of Asthma: Alsalman A. Anam Gullas College of Medicine
ASTHMA
ALSALMAN A. ANAM
GULLAS COLLEGE OF MEDICINE
5 ESSENTIAL FEATURES IN ASSESSING PATIENTS
WITH ASTHMA
Pharmacologic
Acute
Short-term reliever: target bronchoconstriction by relaxing ASM
-agonists,inhaled Albuterol, are the most effective reliever
Methylxanthines (theophyllines) and short-acting anticholinergics such as inhaled corticosteroids
LABAs + inhaled corticosteroid: provide additional control of sympoms
Theophylline: a bronchodilator, sustained anti-inflammatory effect at low dose
Inhaled corticosterioids (budesonide): acute treatment of asthma exacerbations
Omalizumab: specific anti-IgE antibody
Chronic controller
2-AGONISTS
Montelukast, zafirlukast, pranlukast: all inhibit LT receptors, blocking the final step in
LT synthesis
PHOSPHODIESTERASE 4 INHIBITORS
(THEOPHYLLINE)
Is a well established phosphodiesterase inhibitor, with mild anti-inflammatory properties
Has a narrow therapeutic index, not widely used in treating asthma
Currently used in low doses as adjunctive treatment for asthma that is difficult to treat
with steroids alone
SE: anorexia, palpitations, dysrhythmias, seizures
ANTI-IMMUNOGLOBULIN E
Bronchial Thermoplasty
Controlled thermal energy delivered to the airway wall reduction of ASM mass
Shown to reduce airway responsiveness
Requires a series of 3 bronchoscopies