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  • RX 24 Citric Acid Cycle

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    Eko Sumiyanto
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    The document summarizes the citric acid cycle and the role of the pyruvate dehydrogenase complex. It discusses how the complex, composed of three enzymes, catalyzes the oxidative decarboxylation of pyruvate into acetyl-CoA through an irreversible reaction. It also notes that the complex requires five coenzymes and produces NADH, which can generate 3 ATP. Further sections provide more details on the specific enzymes in the complex and how the intermediate compound remains attached to the enzymes during the reaction.

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    Rx 24 Citric Acid Cycle

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    The document summarizes the citric acid cycle and the role of the pyruvate dehydrogenase complex. It discusses how the complex, composed of three enzymes, catalyzes the oxidative decarboxylation of pyruvate into acetyl-CoA through an irreversible reaction. It also notes that the complex requires five coenzymes and produces NADH, which can generate 3 ATP. Further sections provide more details on the specific enzymes in the complex and how the intermediate compound remains attached to the enzymes during the reaction.

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
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    12 views28 pages

    RX 24 Citric Acid Cycle

    Uploaded by

    Eko Sumiyanto
    The document summarizes the citric acid cycle and the role of the pyruvate dehydrogenase complex. It discusses how the complex, composed of three enzymes, catalyzes the oxidative decarboxylation of pyruvate into acetyl-CoA through an irreversible reaction. It also notes that the complex requires five coenzymes and produces NADH, which can generate 3 ATP. Further sections provide more details on the specific enzymes in the complex and how the intermediate compound remains attached to the enzymes during the reaction.

    Copyright:

    © All Rights Reserved
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    of 28

    Citric Acid Cycle

    Citric Acid Cycle


    Overview of the reactions of the pyruvate dehydrogenase complex.

    -Reaksi yg dikatalisis: oksidatif


    dekarboksilasi
    -Bersifat irreversibel. Menghilangkan
    gugus karboksi piruvat
    -Memerlukan 3 enzim dan 5 koenzim
    -Dihasilkan NADH 3 ATP

    Asupan
    vitamin
    B

    Tina Dewi Rosahdi SAINTEK, UIN SGD BDG


    Enzim piruvat dehidrogenase kompleks terdiri dari 3 enzim yaitu:
    1. Pyruvate dehidrogenas (E1)
    2. Dihidrolipoil tranasetilasi (E2)
    3. Dihidrolipoil dehidrogenase (E3)
    Tina Dewi Rosahdi SAINTEK, UIN SGD BDG
    Tina Dewi Rosahdi SAINTEK, UIN SGD BDG
    Pyruvic Acid to Acetyl CoA
    Mechanisms of the pyruvate dehydrogenase complex.

    Senyawa intermediet
    yang dihasilkan dalam
    reaksi ini tetap
    menempel pada
    enzimnya

    Tina Dewi Rosahdi SAINTEK, UIN SGD BDG


    Regulation of the pyruvate dehydrogenase complex by modification
    of E1.

    Tina Dewi Rosahdi SAINTEK, UIN SGD BDG


    Citric Acid Cycle
    Citric Acid Cycle
    Citric Acid Cycle
    Citric Acid Cycle
    1.
    Synthesis
    of citric
    acid
    2.
    Dehydra-
    tion
    3.
    Hydration
    Citric Acid Cycle 4.
    Oxidation
    NAD+ to
    electron
    transport
    5.
    Decar-
    boxy-
    lation
    Remove
    CO2
    Citric Acid Cycle 6.
    Oxidation
    NAD+ to
    electron
    transport
    Decar-
    boxy-
    lation
    Thiol
    synthesis
    Citric Acid Cycle 7.
    Hydrol-
    ysis
    Make
    ATP
    8.
    Oxidation
    9.
    Hydration
    10.
    Oxidation
    Citric Acid Cycle Summary
    Link to vchembook - ATP calculation
    Citric Acid Cycle
    Citric Acid Cycle
    ATP Electron Transport
    ATP from glucose
    ATP
    ATP
    ATP
    ATP
    Hormone Regulation of Carbo- Metabolism
    Hormone Regulation of Carbo- Metabolism
    Insulin - high glucose |||| Glucagon - low glucose
    Response to muscle activity
    Cori Cycle

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