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Glomerulonephritis: Suhardi, D.A
Glomerulonephritis: Suhardi, D.A
Glomerulonephritis: Suhardi, D.A
SUHARDI, D.A.
Division of Nephrology
Department of Internal Medicine,
School of Medicine, Gadjah Mada University/
Sardjitos Hospital
Glomerulonephritis
Glomerulonephritis and glomerulopathy
are usually used interchangeably to
denote: glomerular injury
Glomerulonephritis injury with:
Evidence of inflammation such as
Leukocyte infiltration
Deposition antibody, and
Activation of complement
Immunologic glomerular injury
Classification of Glomerulonephritis
Secondary:
Partof multi system disorder
Systemic Lupus Erythematosus
Systemic features are direct
consequence of glomerular dysfunction
The five mayor clinical
presentations of glomerulopathy
Acute nephritic syndrome
Rapidly progressive glomerulonephritis
(RPGN)
Nephrotic syndrome
Asymptomatic abnormalities of the urinary
sediment (hematuria, proteinuria)
Chronic glomerulonephritis
Acute Glomerulonephritis
Acute glomerular inflammation
Characterized by:
Complete remissions
Partial remissions
Relapse
Dependent
Resistant
Side effect of drugs
Disappointing
After 5-10 years ESRD
Membranous Nephropathy (MN)
Unsatisfying
After 3-10 years 50% progress to ESRD
Membrano Proliferative Glomerulonephritis
(MPGN)
Unsatisfying
There is no effective treatment for the disease
The benefit of treatment are not clear
After 10 years 50% MPGN ESRD
The Treatment of NS
Specific treatment of the underlying
causative disease
General measure to control proteinuria:
Immunosuppressive therapy
Non specific measure:
A II RA
ACE Inhibitor
General measure to control nephrotic
complications:
Edema
Hyperlipidemia
Thromboembolism
Malnutrition
Vit. D deficiency
Conclusion