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Autoimmunity: Dr. Anand Kumar & Dr. R.. A. Siddique N.D.R.I., Karnal (Haryana) India, 132001
Autoimmunity: Dr. Anand Kumar & Dr. R.. A. Siddique N.D.R.I., Karnal (Haryana) India, 132001
Autoimmunity is
a problem of
self/non-self
discrimination.
Autoimmunity
5 % to 7% adult affected.
Molecular mimicry.
Alteration in Ag processing.
Infection.
Genetic factors.
Mechanisms of autoimmunity
Lymphocytes abnormalities.
Hidden Ag released
Stimulate autoimmunity
Antigen generated by molecular changes
Development of completely new epitopes on normal protein. eg RF immuno
conglutinine.
Mech of formation of RF :
Ab + Ag
Triggers autoimmunity.
Alteration in Ag processing
A T cell may fail to develop tolerance to an
self Ag simply because it is not efficiently
procured.
If something happens to improve the
processing, an autoimmune disease may be
triggered.
This usually happens at the site of
inflamation resulting in modified Ab.
Eg. Thyrotoxicosis , diabetese.
Infection
Here autoimmunity is not due to infectious agent
itself ,but results from dis regulation of host
immune response by the microbes.
This may be due to :
Polyclonal lymphocyte activation.
SLE: DLA- A7
POLYARTHRITIS: DLA- A7
Lymphocytes abnormalities
Primary abnormalities either in B cell or T cell.
Since these cells are critical regulators of all IR.
Affects 1% of adults.
Treatment for autoimmunity