HOST MODULATION IN

PERIODONTAL DISEASE
 Host modulation
2

Host can be defined as the organism from which a

parasite obtains its nourishment, or in the
transplantation of tissue, the individual who receives
the graft.

Modulation is defined as the alteration of function or

status of something in response to a stimulus or an
altered chemical or physical environment (Taber's
Medical Dictionary, 2004).
3

First introduced to dentistry by Williams and Golub et

al

Host modulation with chemotherapeutic therapy or

drugs is the latest adjunctive therapeutic option for the
management of periodontal diseases
 Today
5

Paradigm shift in how clinicians and scientists view the

prevalence and progression of this common disease

Theories about the pathogenesis of periodontitis have

evolved from a purely plaque-associated disease to
the more recent hypotheses that place considerable
emphasis on the host's response to the bacteria
6
 Periodontal balance
7
 HOST MODULATION THERAPY (HMT)
8

HMT is a means of treating the host side of the host-

bacteria interaction

Adjunctive to conventional therapies

Do not switch off normal defense mechanisms or

inflammation

Instead, they ameliorate excessive or pathologically

elevated inflammatory processes to enhance the
opportunities for wound healing and periodontal stability.
 TARGETS FOR HOST MODULATION
9
THERAPY
 BLOCK DIRECT EFFECTORS OF BONE &
CONNECTIVE TISSUE (CT) DESTRUCTION
13

Bisphosphonates : Non biodegradable analogs of

pyrophosphate

Have high affinity for calcium

phosphate crystals &

Inhibit osteoclast activity.

Inhibit MMP activity through a

mechanism that involves
chelation of cations
 DISADVANTAGE OF BISPHOSPHONATE
14
THERAPY
Inhibits bone calcification

Induces changes in white blood cell counts.

Reports of avascular necrosis of the jaws following

bisphosphonate therapy, with the resultant risk of bone
necrosis following dental extractions
 The Sleeping Dental Students !!!
LUNCH TIME ACTIVITY POST LUNCH ACTIVITY IN CLASS
 LIFE OF A
DENTAL STUDENT
32 Intact

DENTALORG.COM
CONCLUSION