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EPITHELIUM
EPITHELIUM
By :
Yuningtyaswari, M.Kes
TIK
Mhs mampu menjelaskan tentang jaringan epitel
Mhs mampu menyebutkan & menjelaskan
bermacam tipe epitel, lokasi dan fungsinya di
dalam tubuh
pustaka
Juncqueira, Basic Histology
Leeson & Leeson, Buku Ajar Histologi, EGC
Situs-situs histologi
Organisasi di dalam tubuh mh
Sel jaringan organ sistem organ
Macam sel dlm tubuh coba sebutkan!
Bagian” sel
Cellula
Ground substance (substansia intercellularis)
There are many type ofi tissue in the body :
– Epithel
– Blood
– Connective
– Nervous
– etc
EPITHEL TISSUE
Sheets of cells that cover or line the body surfaces, e.g. :skin,
lining digestive system, lining of body cavities and organs, glands.
. Component :
– Epithelal cell
– Ground substance
Functions
– Barrier formation
– Absorption
– Transport
– Secretion
CLASSIFICATION
Function
– Adhesive surface that hold epithelial cells to connective
tissue.
– Forms a restrictive barrier to growth of epithelial
cells.
– Serves as a semipermeable barrier between tissue
layers. Allows O2 and nutrients to pass through to the
epithelia, and prevents passage of substances (toxic
waste products bacteria etc) that get through epithelia
into the connective tissue.
Basement membrane (membrana basalis)
Appearance
– Light microscope - generally not visible in H and E
stained sections. Reason: made up of a lot of
glycoproteins relatively thin. visible in PAS (periodic
acid Fuchsin Shift), Ag impregnation
– EM - readily apparent as an electron dense line
between specialized cells and connective tissue. At
high power 3 distinct regions visible.
Lamina Lucida - region of adhesion of cells to
lamina densa
Lamina densa - functional core of basement
membrane (basal lamina)
Lamina fibroreticular - region of adhesion of lamina
densa to underlying connective tissue made by
fibroblasts
Basement membrane (membrana basalis)
Composition
– Extracellular matrix - gel-like substances that are
secreted from a cell. Made up of ground substance,
fibrillar proteins and glycoproteins
– Ground substance-mixture rich in very large
carbohydrate polymers
– Fibrillar proteins - Collagen type IV epithelia found in
lamina densa
– Glycoproteins - Laminin, entactin: glue that holds
extracellular matrix together. Laminin binds integrins,
collagen IV, heparin sulfate, entactin
Basement membrane (membrana basalis)
– Adhesion of epithelial cells to basement membrane
– Non visible - Numerous integrins bind to laminin, collagen IV or
ground substance
– Junction visible in the EM: hemidesmosome
– Function - a cell-extracellular matrix junction that holds
epithelial cells to underlying connective tissue
– Appearance - in the EM, plaques on the basal lateral
membrane are observed that have intermediate filaments
running into them.
– Composition
Integrin - adheres to Type VII collagen (linker binding)
Integrin - cytoplasmic tail linked to desmoplakin
Desmoplakin binds to intermediate filaments
JUNCTION BETWEEN EPITHELIAL CELLS
a. Ducts
– Simple vs. compound
– Straight vs. coiled
– Secretory portion
b. Tubular (pipe) vs. ascinar (vesicle)
Epithelium simple squamousum
Corpusculum renalis
Lining blood vessel
Epithelium Pseudostrat. Columnare ciliatum
trachea
Epithelium Simple Columnare
intestinum
E. Transitional
Urinary bladder
E. Squamosum Stratificatum
Body skin
Ep. Simple Cuboidal
Tubulus renalis
A single layer of cuboidal cells with rounded nuclei, lying on a
basement membrane. They are often found lining ducts and may possess
basal infoldings. Function: They transport fluids and may modify the
contents of the lumen by selective absorption.
Function:
Absorption, lubrication or movement of luminal contents.
Pseudostratified Epith.
Trachea
Pseudostratified
Epididymis
Stratified columnar/cuboidal
epith