DIGESTIVE GLANDS

IKA MURTI H.
LAB. HISTO-KEDOKTERAN
 Outlines
• Oral cavity
• Digestive tract
• Digestive glands
 Digestive glands
• Major salivary glands
• Pancreas
• Liver
• Gall bladder
 Salivary glands
• Produce saliva
– Tasting food
– Initiate digestion
– Permits deglutition
– Protective
• Major salivary glands:
– Parotid
– Submandibularis
– Sublingualis
• Tubuloalveolar glands
• Septa
 Regions of salivary glands
• Secretory portion
– Arranged in tubules & acini
– Serous cell: truncated pyramid, round nuclei
– Mucous cell: truncated pyramid, flattened nuclei
– Basket cell/myoepithelial cell
 Regions of salivary glands
• Duct portion
– Intercalated ducts: simple squamous epithelium +
myoepithelial cell
– Striated ducts: simple cuboidal-low columnar
epithelium
– Intralobular ducts  interlobular/intralobar ducts
 intralobar ducts
Salivary gland
 Parotid gland
• Largest salivary
gland
• 20-30 g
• 30% saliva
• Serous secret
• Secretory IgA
• Amylase saliva
Parotid gland
 Submandibular gland
• 12-15 g
• 60% saliva
• 90 % serous
• 10 % mucus
 Sublingual gland
• 2-3 g
• Mucus tubular gland
capped by serous
demiluna
• Mixed secret, mainly
mucous
 Pancreas (exocrine)

 Compound tubuloacinar gland

 Secretory portion

 Acinar cell

 Zymogenic granules

 Produce digestive enzymes

 Have receptor for cholecystokinin + acetylcholine

 Cont’d…
 Duct portion
 Intercalated duct: centroacinar cell

 Produce bicarbonate-rich buffer solution

 Have receptor for secretin

 Intralobular duct  interlobular duct  main

pancreatic duct  papilla vater

Pancreatic asinus
Pancreas: centroacinar cell
Pancreas
 Liver
• Endocrine & exocrine gland
• Capsule of Glisson
• Hepatocytes
– Hexagon-shaped lobules/classical
– Central vein
• Portal triads
– Hepatic artery
– Portal vein
– Interlobular bile duct
Hepatic architecture
Hepatic architecture
Hepatic architecture
Portal triad
 Liver lobules
• Classical liver lobule
– Central vein as the center
– Blood flow from peripheral to central vein
• Portal lobule
– Portal area as the center
– Triangular region
• Hepatic acinus
– Ovoid/diamond-shaped lobule
– Based on blood flow from arteriole
• 3 regions
Hepatic lobules
 Hepatic sinusoids
• Hepatocyte radiates from central vein 
hepatocyte plate
• Hepatic sinusoids  sinusoidal lining cells
• Space of Disse
• Kupffer cell
• Ito cell
Liver:Kupffer cell
Hepatic sinusoids
Hepatic sinusoids
Hepatocytes
Hepatocyte
 Hepatocyte functions
• Bile manufacture
• Lipid metabolism
• Carbohydrate & protein metabolism
• Vitamin storage
• Degradation of hormone
• Detoxification of drugs & toxin
Hepatocyte function
 Gall bladder
• Pear-shaped
• Body & neck/cystic duct
• Histology:
– Simple columnar epithelium
– Lamina propria
– Smooth muscle
– Serosa
Gall bladder
Gall bladder
Gall bladder epithelium
TERIMAKASIH