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Chemical Engineering and Chemistry: Education in A Changing World
Chemical Engineering and Chemistry: Education in A Changing World
Jetse C. Reijenga
engineering
100000
10000
1000
1950's 1960's 1970's 1980's 1990's 2000's
period
Source: http://scholar.google.com
Citations Explosion
annual number of CA abstracts
900000
800000
700000
600000
500000
400000
300000
200000
100000
0
1950's 1960's 1970's 1980's 1990's 2000's
1200000
1000000
800000
600000
400000
200000
0
1900 1915 1930 1945 1960 1975 1990 2005
Source: E.L. Cussler and J. Wei, A.I.Ch.E. Journal, 2003, 49(5), 1072-1075
From the old paradigm…..
• Practicals (2 students*)
Source: http://w3.chem.tue.nl/en/
Increased Emphasis on Group Work
50
40
% groupwork
30
20
10
0
1975 1980 1985 1990 1995 2000 2005
Multi-disciplinary Project Work - goals
J.C. Reijenga, H. Siepe, L.E. Yu, C.-H. Wang, Chem. Eng. Educ. 37(2), 14-19
(2003)
Bridging the Gaps……
Theoretical Concepts
Theoretical model
"equipment" Data
Equipment parameters
Database
Source: http://edu.chem.tue.nl/ce
Source: J.C. Reijenga, J. Chromatogr., 1991, 588, 217-224
title
Source: J.C. Reijenga, E. Kenndler, J. Chromatogr. A, 1994, 659, 403-415 and 417-
title 426
Source: J.C. Reijenga, and M. Hutta, J. Chromatogr. A, 1995, 709, 21-29
Source: J.C. Reijenga, J. Chromatogr. A, 2000, 903, 47-54
title
HPLC simulator specs #1
75 sample
0 - 65 oC components
1 - 10 mm
1 - 25 µm
MeOH
ACN
• heat treatment
• gel filtration
• ammonium Sulphate fractionation
• ion exchange chromatography
• hydrophobic interaction chromatography
• preparative isoelectric focusing
• affinity chromatography
• 1D and 2D PAGE for purity check
Source: http://www.york.ac.uk/depts/chem/staff/elaborate/packages/
Simulations - from macro to micro
• so far: simulation of detector signals as final result
• zoom in on time scale - from minutes to milliseconds
• zoom in on distance scale:
• from meters to millimeters (during separation in column)
• from millimeters to micrometers (boundary layer effects)
• from micrometers to nanomaters (molecular level details)
Source: http://www.cofc.edu/~kinard/Applets/ChromatographyAnimation.gif
CZE/ITP
Source: http://edu.chem.tue.nl/ce/stackweb/
title
Simul 4.0