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HistologI Sistem Imun 2012
HistologI Sistem Imun 2012
SISTEM IMUN
E. A. JALAL
LIMFOSIT DAN ORGAN LIMFOID
LYMPHOCYTE AND LYMPHOID ORGANS
The Lymphoid Organs
Bone marrow
Thymus
Peripheral/Secondary lymphoid
organs
Lymph nodes
Spleen
Mucosa-associated lymphoid tissue
(MALT)
Limfosit dibentuk
didalam sumsum tulang
Dari sel induk limfosit
(progenitor) dihasilkan 3
macam sel:
Limfosit B (B cell)
Limfosit T (T cell)
Sel NK (natural killer cell)
Secara morfologis
identik, dibedakan
dengan mengenali
molekul protein pada
permukaan sel (marker)
Bone Marrow
Thymus
Cortex
Medulla
Hassal corpuscle
Thymus
T cells development in thymus
CD8+, CD3+ αβ TCR Naïve
Cytotoxic T Cells
Thymus derived
lymphocytes CD4+, CD3+ αβ TCR Naïve
( T Lymphocytes) Helper T Cells
CD4+, αβ TCR NK T /
Natural Killer T Cells
CD3+, γδ TCR
γδT Cells
Lymphocytes mature in the bone
marrow or the thymus,
then congregate in lymphoid
tissue throughout the body
• The lymph nodes
filter out antigens
draining from the
peripheral bodily
tissues.
A lymph node
Capsula fibrosa
Cortex
Para cortex
Medulla
Hylus
Figure 1-8 part 1 of 2
Lymphonodules Germinal center
Afferen lymph vessel
Sinus sub capsularis
Sinus trabecularis
High Epithelial Venule
IELs
Intra Epithelial
Lymphocytes
LP
Lamina Propria
Lymphocytes
ILF
Isolated Lymphoid
Follicles
PP
Peyer’s Patches
MLN
Mesenteric Lymph
Nodes
Mucosal Immune System