Professional Documents
Culture Documents
Created by Cindy Montana at Washington University in St. Louis
Created by Cindy Montana at Washington University in St. Louis
Created by Cindy Montana at Washington University in St. Louis
com
Pathways Oculomotor / Oculodominance
Somatosensory Sleep
Pain Memory
Motor Language
Note: If a slide says CLICK, click outside the buttons to advance the animation until CLICK disappears.
Otherwise, use the arrow buttons (top right) to navigate between slides.
Pathways
• Fine Touch
• Pain/Temperature
• Proprioception
• Corticospinal/Corticobulbar
• Rubrospinal/Tectospinal
• Reticulospinal
• Vestibulospinal
MAIN
FINE TOUCH
CLICK Spinal Cord
dorsal root
ganglion
gracile fasciculus dorsal
columns
cuneate fasciculus
S
T L Aβ fibers (large)
C enter the spinal
afferent Aβ fiber cord medial to
1st order Aδ, C fibers
(small)
sacral
lumbar
thoracic
cervical
MAIN SECTION
FINE TOUCH
CLICK Medulla
gracile nucleus
cuneate nucleus
internal
arcuate
fibers
2nd order medial
lemniscus
2nd order
CROSS
sacral
lumbar
thoracic
cervical
MAIN SECTION
FINE TOUCH
CLICK Pons
trigeminal
motor
nucleus
trigeminal
ganglion
trigeminal main
sensory nucleus
sacral
lumbar
medial lemniscus
thoracic
2nd order
cervical
trigeminal – sensory
MAIN SECTION
FINE TOUCH
CLICK Midbrain
inferior
colliculus
lateral lemniscus
medial
sacral
lemniscus
lumbar
2nd order
thoracic
cervical
trigeminal – sensory
MAIN SECTION
FINE TOUCH
CLICK Midbrain
superior
colliculus
lateral
lemniscus
sacral
lumbar
thoracic
cervical
trigeminal – sensory
MAIN SECTION
FINE TOUCH
CLICK Forebrain
primary somato-
sensory cortex
internal capsule click here
3rd order
click here for
horizontal section
VPL*
VPM*
sacral
lumbar
thoracic
cervical
trigeminal – sensory
MAIN SECTION
Internal Capsule – Horizontal Section
anterior limb
genu
posterior limb
sacral
lumbar
thoracic
cervical
trigeminal – sensory
MAIN SECTION
PAIN/TEMP
CLICK Spinal Cord
RL = Rexed lamina
Aδ fiber
dorsal root
1st order
ganglion posterior marginalis (RL I)
substantia gelatinosa (RL II)
C fiber
1st order nucleus proprius
(RL III, IV)
Aδ, C fibers
(small) enter the Lissauer’s tract
spinal cord
lateral to Aα
fibers (large)
interneuron
CROSS
S
C T L
sacral 2nd order tracts:
lumbar spinothalamic/
thoracic spinoreticular/
spinomesencephalic
cervical
anterior white commissure
2nd order MAIN SECTION
PAIN/TEMP
CLICK Medulla Show Spinoreticular Tract
trigeminal
afferent
1st order
trigeminal
spinal nucleus
CROSS
pontine reticular
formation
trigeminal
ganglion
trigeminal
spinal tract
1st order
spinothalamic,
trigeminal
sacral spinomesenephalic
afferent tracts
lumbar 1st order 2nd order
thoracic [to medulla]
cervical
trigeminal – sensory
MAIN SECTION
PAIN/TEMP
CLICK Midbrain
inferior
colliculus
spinothalamic/
spinomesen-
cephalic tracts
2nd order
medial
sacral
lemniscus
lumbar
thoracic
cervical
trigeminal – sensory
MAIN SECTION
PAIN/TEMP
CLICK Midbrain Show
Spinomesencepahalic Tract
spinothalamic tract
superior
2nd order
colliculus
periaqueductal
gray (PAG)
mesencephalic
reticular
formation
sacral
lumbar
thoracic
cervical
trigeminal – sensory
MAIN SECTION
PAIN/TEMP
CLICK Forebrain
primary somato-
sensory cortex
internal capsule Spinothalamic tract click here
(posterior limb) (no evidence for
3rd order orderly topographic
cortical map)
VPL*
VPM*
sacral
lumbar
thoracic
cervical
trigeminal – sensory
MAIN SECTION
PROPRIOCEPTION
CLICK Spinal Cord - Sacral
dorsal root
ganglion dorsal columns
afferent Aα fiber
1st order
Aα fibers (large)
enter the spinal
cord medial to
Aδ, C fibers
(small)
MAIN SECTION
PROPRIOCEPTION
CLICK Spinal Cord - Thoracic
dorsal
spinocerebellar
tract
nd
2 order
Clarke’s nucleus
(dorsal nucleus)
T1-L2
MAIN SECTION
PROPRIOCEPTION
CLICK Spinal Cord - Cervical
afferent Aα fiber
1st order dorsal columns
dorsal root
ganglion
dorsal
spinocerebellar
tract
2nd order
MAIN SECTION
PROPRIOCEPTION
CLICK Medulla
cuneocerebellar tract
2nd order
dorsal
spinocerebellar
tract
2nd order
external (accessory)
cuneate nucleus
MAIN SECTION
PROPRIOCEPTION
CLICK Medulla
inferior
cerebellar peduncle
2nd order
MAIN SECTION
PROPRIOCEPTION
CLICK Cerebellum
medial (fastigius)
interposed (globose +
deep cerebellar nuclei (see right) emboliform)
lateral (dentate)
mossy fibers
inferior cerebellar
peduncle (restiform body)
MAIN SECTION
PROPRIOCEPTION
CLICK
afferent Aα fiber
Pons
(from masseter, temporalis)
mesencephalic ganglion
trigeminal
ganglion
efferent α-MN in CN V3
(to masseter, temporalis)
MAIN SECTION
CORTICOSPINAL/
CORTICOBULBAR
Forebrain
CLICK
corona Precentral,
radiata prefrontal,
postcentral gyri
internal capsule
(posterior limb)
cerebral
peduncle
superior
colliculus
oculomotor
nucleus
red nucleus
cerebral
peduncle
inferior
colliculus
trochlear
nucleus
middle
cerebellar
peduncle
corticospinal
tract
to lumbar spinal cord
to cervical spinal cord
to CN motor nuclei
MAIN SECTION
CORTICOSPINAL/
CORTICOBULBAR
Pons
CLICK
abducens (CN VI) middle
nucleus cerebellar
peduncle
nucleus
ambiguous
trigeminal (CN V)
spinal nucleus
CROSS
pyramidal
decussation
MAIN SECTION
CORTICOSPINAL/
CORTICOBULBAR
Spinal Cord - Cervical
CLICK
ventral white
commissure
lateral
corticospinal
tract
CROSS PF DF
PE DE Regions of the ventral horn
that innervate…
- proximal flexors = PF
- distal flexors = DF
- proximal extensors = PE
ventral horn - distal extensors = DE
anterior
to lumbar spinal cord corticospinal
to cervical spinal cord tract
MAIN SECTION
CORTICOSPINAL/
CORTICOBULBAR
Spinal Cord - Thoracic
CLICK
lateral
corticospinal
tract
anterior
to lumbar spinal cord corticospinal
tract
MAIN SECTION
CORTICOSPINAL/
CORTICOBULBAR
Spinal Cord - Sacral
CLICK
CROSS
ventral horn
anterior
to lumbar spinal cord corticospinal
tract
MAIN SECTION
RUBROSPINAL/
TECTOSPINAL
Midbrain
CLICK input from forebrain
ventral tegmental
decussation
red nucleus
rubrospinal
tectospinal
MAIN SECTION
RUBROSPINAL/
TECTOSPINAL
Pons
CLICK
tectospinal tract
rubrospinal tract
pontine reticular
formation
rubrospinal
tectospinal
MAIN SECTION
RUBROSPINAL/
TECTOSPINAL
Medulla
CLICK tectospinal
MLF
tract
medullary
reticular
formation
rubrospinal
tract
rubrospinal
tectospinal
MAIN SECTION
RUBROSPINAL/
TECTOSPINAL
Medulla
CLICK
trigeminal (CN V)
spinal nucleus
rubrospinal
tract
pyramidal
decussation
tectospinal
tract
rubrospinal
tectospinal pyramid
MAIN SECTION
RUBROSPINAL/
TECTOSPINAL
Spinal Cord - Cervical
CLICK
rubrospinal
tract
rubrospinal tectospinal
ventral horn
tectospinal tract
MAIN SECTION
RUBROSPINAL/
TECTOSPINAL
Spinal Cord - Lumbar
CLICK
rubrospinal
tract
ventral horn
rubrospinal
MAIN SECTION
RETICULOSPINAL
CLICK Pons
medial longitudinal pontine reticular
fasciculus (MLF) formation
MAIN SECTION
RETICULOSPINAL
CLICK Medulla
MLF
MAIN SECTION
RETICULOSPINAL
CLICK Medulla
MLF
MAIN SECTION
RETICULOSPINAL
CLICK Spinal Cord - Cervical
MAIN SECTION
RETICULOSPINAL
CLICK Spinal Cord - Thoracic
MAIN SECTION
RETICULOSPINAL
CLICK Spinal Cord - Lumbar
MAIN SECTION
VESTIBULOSPINAL
CLICK Pons
medial longitudinal fasciculus (MLF)
lateral vestibular
nucleus
medial vestibular
nucleus
MAIN SECTION
VESTIBULOSPINAL
CLICK Medulla
MLF
MAIN SECTION
VESTIBULOSPINAL
CLICK Spinal Cord - Cervical
MAIN SECTION
VESTIBULOSPINAL
CLICK Spinal Cord - Thoracic
MAIN SECTION
VESTIBULOSPINAL
CLICK Spinal Cord - Lumbar
MAIN SECTION
Brainstem Atlas
• Open Medulla
• Lower Pons
• Middle Pons
• Upper Pons
• Midbrain
MAIN
Medial Syndrome
Lateral Syndrome Open Medulla
medial vestibular nucleus
CN XII medial longitudinal
nucleus fasciculus dorsal motor nucleus
medial lemniscus of the vagus
nucleus of
the solitary
spinal trigeminal tract
tract
inferior
cerebellar
spinal trigeminal peduncle
nucleus
solitary tract
inferior olivary
fibers nucleus
ambiguus
inferior olivary
pyramids nucleus
MAIN SECTION
Medial Syndrome
Lateral Syndrome Lower Pons
medial vestibular nucleus
medial medial longitudinal
CN VI
lemniscus fasciculus lateral vestibular nucleus
nucleus
raphe
nuclei
middle
superior olivary
cerebellar
nuclear complex
peduncle
pontine nuclei
corticospinal tract
MAIN SECTION
Medial Syndrome
Lateral Syndrome Middle Pons
CN V
mesencephalic
CN V main CN V motor nucleus
sensory nucleus nucleus
CN V
mesencephalic
tract
lateral
lemniscus
MAIN SECTION
Medial Syndrome
Lateral Syndrome Upper Pons
medial longitudinal
fasciculus
parabrachial region
medial lemniscus
periaqueductal gray
corticospinal
tract
pontocerebellar fibers
MAIN SECTION
superior [inferior is caudal] colliculus
Midbrain
periaqueductal gray
superior cerebellar
peduncle
Click here to expand this
region
medial
lemniscus
red nucleus
cerebral peduncle
CN III
Tegemental Syndrome
Ventral Syndrome
MAIN SECTION
Brainstem Syndromes
• Medial Medullary
• Lateral Medullary
• Medial Inferior Pontine
• Lateral Inferior Pontine
• Medial Mid-Pontine
• Lateral Mid-Pontine
• Medial Superior Pontine
• Lateral Superior Pontine
• Tegmental
• Ventral
MAIN
Medial Medullary Syndrome
CN XII medial longitudinal
nucleus fasciculus
medial lemniscus
nucleus
ambiguus
descending
symapthetic
tract Loss of facial pain/temp sensation
(ipsilateral)
Hoarseness, difficulty swallowing
Horner’s syndrome, ipsilateral loss of
sweating
dorsal Cerebellar ataxia
spinocerebellar Loss of body pain/temp sensation
tract (contralateral)
spinothalamic tract
corticospinal tract
CN VII
corticobulbar
tract
corticopontine/
pontocerebellar fibers
lateral
lemniscus
Weakened mastication
Loss of facial sensation (ipsilateral)
No deficit reported
central tegmental
bundle
medial lemniscus
corticospinal
tract
pontocerebellar fibers
spinothalamic tract
medial lemniscus
Cerebellar ataxia
Loss of body pain/temp sensation
(contralateral)
Loss of fine touch (contralateral)
pontocerebellar
fibers
medial
lemniscus
Cerebellar ataxia
Loss of fine touch to body and face
(contralateral)
red nucleus
No deficit reported
Loss of pupil constriction; lateral
strabismus
CN III
Paralysis (contralateral)
Loss of pupil constriction; lateral
strabismus
cerebral peduncle
CN III
MAIN
Lesions - Peripheral
MAIN SECTION
Lesions - Spinal Cord
MAIN SECTION
Lesions - Forebrain
MAIN SECTION
Peripheral Receptors
Click on a receptor:
Merkel’s disk
Epidermis
Dermis
Meissner’s corpuscle
Pacinian corpuscle
Ruffini ending
MAIN SECTION
Merkel’s Disk
Discriminative Touch Mechanoreceptor
Location: Epidermis
Specificity: Steady skin indentation – form, texture
Dynamics: Slow-adapting
Spatial Range: Small receptive field (3-4 mm fingers, 30-40 cm trunk)
2-point discrimination threshold = 1 mm fingers, 10 cm trunk
Conduction: Aδ fiber – 25 m/s
Location: Dermis
Specificity: Flutter; contact and movement
Dynamics: Fast-adapting
Spatial Range: Small receptive field (3-4 mm fingers, 30-40 cm trunk)
2-point discrimination threshold = 1 mm fingers, 10 cm trunk
Conduction: Aδ fiber – 25 m/s
Location: Dermis
Specificity: Low frequency stimulation
Dynamics: Slow-adapting
Spatial Range: Large receptive field
Conduction: Aδ fiber – 25 m/s
Aδ C
Specificity Cold or fast pain Warmth or slow pain
1 7
2
3b
4 5
3a
M1
lateral sulcus
S2 posterior
parietal lobule
MAIN SECTION
Somatosensory Cortex
postcentral gyrus intraparietal sulcus Click on an area:
central sulcus
posterior
parietal lobule central intraparietal
postcentral gyrus – S1
sulcus sulcus
1 7
2
3b
4 5
3a
M1
lateral sulcus
S2 posterior
parietal lobule
1 7
2
3b
4 5
3a
M1
lateral sulcus
S2 posterior
parietal lobule
S1 – Area 3b
• Input from thalamic core (VPM/VPL - cutaneous) Click here for S1 topography
• Each column within 3b is specific for one type of Click here for S1 histology
cutaneous receptor
• Smallest RFs
MAIN SECTION
Somatosensory Cortex
postcentral gyrus intraparietal sulcus Click on an area:
central sulcus
posterior
parietal lobule central intraparietal
postcentral gyrus – S1
sulcus sulcus
1 7
2
3b
4 5
3a
M1
lateral sulcus
S1 – Area 1 S2 posterior
• Input from 3b and thalamic core (cutaneous) parietal lobule
• Large, complex RFs – combine info from multiple
receptor types Click here for S1 topography
• Sensitive to motion, direction, orientation Click here for S1 histology
• Primarily tactile info
• LESION trouble describing texture
MAIN SECTION
Somatosensory Cortex
postcentral gyrus intraparietal sulcus Click on an area:
central sulcus
posterior
parietal lobule central intraparietal
postcentral gyrus – S1
sulcus sulcus
1 7
2
3b
4 5
3a
M1
lateral sulcus
S1 – Area 2 S2 posterior
• Input from 3a, 3b and thalamic core (cutaneous) + parietal lobule
shell (muscle)
• Large, complex RFs Click here for S1 topography
• Combines tactile and muscle info Click here for S1 histology
• LESION poor stereognosis, can’t pick up small
objects or maneuver hand through tight places
MAIN SECTION
Somatosensory Cortex
postcentral gyrus intraparietal sulcus Click on an area:
central sulcus
posterior
parietal lobule central intraparietal
postcentral gyrus – S1
sulcus sulcus
1 7
2
3b
4 5
S2 3a
• Input from S1 and thalamus
lateral sulcus
M1
1 7
2
3b
4 5
3a
M1
lateral sulcus
S2 posterior
parietal lobule
Area 5
• Input from area 2 (S1) Click here for S1 topography
• Cutaneous plus movement Click here for S1 histology
• Very complex RFs: Multi-joint, multi-limb
• Responds differently to active and passive movement
MAIN SECTION
Somatosensory Cortex
postcentral gyrus intraparietal sulcus Click on an area:
central sulcus
posterior
parietal lobule central intraparietal
postcentral gyrus – S1
sulcus sulcus
1 7
2
3b
4 5
3a
M1
lateral sulcus
S2 posterior
parietal lobule
• Extremely distorted
MAIN SECTION
Somatosensory Cortex
I
II
III
VI
MAIN SECTION
Somatosensory Plasticity
• Finger amputated corresponding cortical areas are
taken over by adjacent finger representations
• Types of Pain
– Nociceptive
– Inflammatory
– Neuropathic
• Central Pain Modulation
• Sensitization
– Peripheral
– Central
MAIN
Nociceptive Pain
TISSUE ACTIVATE
INJURY NOCICEPTORS
Types of Nociceptors
MAIN SECTION
Inflammatory Pain
INFLAMMATORY
MEDIATORS
INSULT
NOCICEPTOR
ACTIVATION
MAIN SECTION
Neuropathic Pain
REPETITIVE STRESS
LESION
INJURY (TO NERVES)
PAIN
MAIN SECTION
Types of Nociceptors
Fiber type
Channel types
Nociceptor Responds to… Myelination Type of pain
(Transduction)
Conduction
nucleus raphe
magnus (NRM)
NOTE:
1) Dorsal horn neuron also receives dorsal horn
descending pain-facilitation inputs.
2) Serotonin has other indirect effects,
involving opiate receptors and
enkephalins.
inhibits
5-HT
MAIN SECTION
CLICK Sensitization - Peripheral
Injury Sensitization can occur via:
1) Potentiation of sensory transduction channel function
2) Enhancement of neuronal excitability
dorsal horn
nociceptor /
peripheral ending excite
histamine
degranulation
stimulate
mast cell
MAIN SECTION
CLICK Sensitization - Central
Limbic augmentation Repeated stimulation
(anxiety, anticipation, etc.) + (e.g., by nociceptors)
Hyperphosphoryl-
ation of ion channels
nociceptor in dorsal horn
terminus neurons
dorsal horn .. .
.
P
P P Increased
excitability of dorsal
horn neurons
P P
P
Chronic
pain
MAIN SECTION
Motor
• Motor Pathways
• Deficits/Lesions
• Motor Cortex
• Reflexes
• Posture
• CN VII
• Basal Ganglia
• Cerebellum
MAIN
Motor Pathways
• Motor input to CN nuclei: Corticobulbar tract
• Other:
– Rubrospinal tract is involved in voluntary limb movements
MAIN SECTION
Motor Deficits
Disease of Fasciculation
Weakness or paralysis (spontaneous firing of an axon twitch of
motor neurons all fibers in the motor unit)
MAIN SECTION
Damage to Descending Pathways
• Effect on stretch reflexes
– Autonomous and overactive (exaggerated)
– Claspknife reaction
• Passively extend limb spindle stretch-induced contraction (resistance)
activate GTO sudden relaxation
– Clonus
• Rhythmic contraction-relaxation tremor
• Occurs when you suddenly stretch a muscle and hold at a longer length
• Due to cyclic alternations of stretch reflex, GTO, and Renshaw inhibition
MAIN SECTION
Cortical Regions
Area 6 M1 (Area 4) central sulcus
PMA SMA
S1
Area 5 posterior
prefrontal parietal
cortex cortex
Area 7
MAIN SECTION
Primary Motor Cortex (M1)
• Motor cortical neurons fire to cause voluntary movement (via corticospinal/
corticobulbar pathways)
– Lesions in this pathway (prior to synapse in the spinal cord ventral horn) result in
“upper motor neuron” deficits
• Impaired movement at individual joints
• Weakness
• Increased sensitivity and magnitude of spinal reflexes (stretch & nociceptive)
– Irritation in the cortex can cause seizures
• Focal (face or arm or leg) or “marching” (face arm leg)
• Columnar organization
– Different neurons code for muscle force, joint position, movement direction
• Specialty: Moving single digits – must actively hold other digits still (digits 3, 4,
5 have individual tendons but just one muscle)
M1 topography M1 histology
I
II
III
contains large
V pyramidal Betz cells
VI
• Muscle Spindle
• Golgi Tendon Organ
• Reciprocal Inhibition
• “Crossed Extension” Flexor Reflex
• Locomotion
• Transcortical Reflex
MAIN SECTION
CLICK Muscle Spindle
chain fiber bag fiber
1a or II
afferent
γ1- or 1a*
γ2-MN to spinal
quadriceps
cord
α-MN II*
from
spinal
muscle spindle cord
γ1-MN*
biceps tendon
γ2-MN*
1) Hit tendon
2) Spindle stimulated (1a, II)
3) α-MN fires muscle contracts
Renshaw cell stimulated α-MN * * click on label for details
γ-MN fires spindle fibers contract
Muscle spindle is involved in…
4) Renshaw cell inhibits α-MN
(click here)
inhibitory interneuron
to spinal
α-MN
cord Ib afferent
1) High muscle tension (force)
2) GTO stimulated (Ib)
3) Interneuron inhibits α-MN
from
4) α-MN decreases firing
spinal
5) Decreased muscle tension
cord α-MN
muscle spindle
α-MN to
agonist
agonist muscle
(flexor)
inhibitory ACTIVATED
interneuron
α-MN to
antagonist
antagonist muscle
(extensor)
INHIBITED
Applications
• Spinal withdrawal reflex
– Hurtful stimulus withdraw stimulated limb + extend opposite
limb
• Locomotion
– Brainstem activity oscillation of leg flexion and extension
midbrain locomotor
region (MLR)
corticospinal tracts
reticulospinal tract
Modify locomotory
Initiate locomotory activity activity for voluntary
in spinal cord circuits corrections of gait
(obstacle avoidance)
If you combine head tilt with neck flexion/extension, either… Tips for learning this chart
- the tonic neck reflex will CANCEL the vestibulospinal reflex, or
- the tonic neck reflex will ADD to the vestibulospinal reflex. Abnormal Posture
MAIN SECTION
Normal Postural Reflexes
1) Vestibulospinal
Know that for VSR alone
reflexes can(head movement
act ALONE only),
if you head
tilt your up
head forelimbs
up/down flex &extending/flexing
without hindlimbs extendyour(andneck.
opposite
Tonic neckifreflexes
head is can
down).act ALONE if you extend/flex your neck without tilting your head up/down.
2) Know that for TNR alone (neck movement only), neck extended forelimbs extend & hindlimbs flex (and
If opposite
you combineif neck is flexed).
head tilt with neck flexion/extension, either…
3) - Combining a head movement
the tonic neck reflex will CANCEL and neck movement: reflex, or
the vestibulospinal
• If the limb positions resulting from VSR and TNR agree, then the reflexes add (limb hyper-extension/flexion).
- the tonic neck reflex will ADD to the vestibulospinal reflex.
• If the limb positions resulting from VSR and TNR disagree, then the reflexes cancel (no limb movement).
MAIN SECTION
Abnormal Posture
• Flexion of upper limb,
DECORTICATE
MAIN SECTION
CN VII Innervation
R L
CN VII nuclei
NORMAL
Click on a lesion site (circled in purple)
MAIN SECTION
CN VII Innervation
R L
X
to lower facial muscles (left)
CN VII nuclei
MAIN SECTION
CN VII Innervation
R L
CN VII nuclei
MAIN SECTION
Basal Ganglia
ROSTRAL
Lenticular nucleus = Globus pallidus + Putamen
Striatum = Globus pallidus + Putamen + Caudate
Connections NTs
Selection-Brake
Diseases
CAUDAL
Caudate
Putamen
SNpc SNpr
dopaminergic GABAergic
MAIN SECTION BG
Basal Ganglia Neurotransmitters
• Dopamine
• GABA
• Enkephalin
• Substance P
• Glutamate
• ACh
NOT norepinephrine
MAIN SECTION BG
CLICK Basal Ganglia Connections
cerebral cortex
= excitatory (Glu)
= inhibitory (GABA)
= mixed (DA)
= unknown
SC = superior colliculus
caudate / putamen
PPPA = peri-pedunculo-pontine area
VA/VL = ventroanterior/ventrolateral
nuclei of thalamus VA/VL
SNpc
GPe STN
But most of the caudate/putamen output goes to the GP and SNpr. SNpr PPPA
The SNpr projects outside the basal ganglia to control head/eye movements.
MAIN SECTION BG
Selection-Brake Hypothesis
MAIN SECTION BG
Basal Ganglia Diseases
General Pathophysiology
MAIN SECTION BG
Parkinson’s Disease
• Caused by degeneration of the SNpc (dopaminergic)
– SNpc modulates putamen and caudate
– Putamen/caudate can no longer “focus” the GPi output
• Symptoms
– Rigidity, bradykinesia, akinesia, pill-rolling tremor
– Can be mimicked by taking dopamine receptor blockers
• Treatment
– Give oral L-dopa, a precursor to dopamine
• Too much L-dopa develop chorea/hemiballismus (involuntary,
gesture/dance-like movements)
– Ablate or electrically stimulate the STN
• This causes chorea in normal subjects, but restores normal function
to Parkinson’s patients
MAIN SECTION BG
Huntington’s Disease
• Caused by damage of the caudate/putamen or
STN
– Results in excessive activity in the caudate/putamen
• Symptoms
– Chorea, athetosis, hemiballismus
• Writhing, purposeful-looking but involuntary movements
• Hemiballismus is specifically caused by STN lesion
• Treatment
– Drugs that block dopamine receptors in the putamen
– Is worsened by L-dopa or dopamine agonists (unlike
in Parkinson’s)
MAIN SECTION BG
Cerebellum
• Folium
• Cortical Cells
• Deep Nuclei
• Connections
MAIN SECTION
Cerebellar Folium
Click here to overlay cell
types/connections
molecular layer
white matter
MAIN SECTION CB
Cerebellar Folium
Click on a cell type:
Purkinje cell
Climbing fiber
dendrite Granule cell
parallel fiber
Mossy fiber
dendrite synapse
axon
MAIN SECTION CB
Purkinje Cell
• One Purkinje cell receives
molecular layer
input from…
– One climbing fiber
Purkinje cell – Many parallel fibers (up to a
dendrite
million)
• Inter-Purkinje cell
connections via parallel fibers
granule cell layer
MAIN SECTION CB
Climbing Fiber
• Cell bodies reside in the inferior
molecular layer
olive
MAIN SECTION CB
Granule Cell
• Receives input from mossy fibers
molecular layer
MAIN SECTION CB
Mossy Fiber
• Originates in the…
molecular layer
– Spinocerebellar pathway
• Ascending (from spinal cord)
• Fibers do not cross
• Enters cerebellum through the
inferior cerebellar peduncle
– Pons
• Descending (from cerebral
cortex)
granule cell layer
MAIN SECTION CB
Inhibitory Interneurons
Stellate cell
• Molecular layer
Basket cell
• Cell body in molecular layer
• Projections wrap around Purkinje cell
Purkinje cell
basket cell
body
Golgi cell
• Granule cell layer
MAIN SECTION CB
Cerebellar Deep Nuclei
• Receive inhibitory input from Purkinje cortical cells Click on a nucleus:
• Project to brainstem and thalamus – click here
Fastigial (medial) nucleus
• Each nucleus has a separate body map
• Help initiate movement – click here Globose/emboliform
(intermediate) nuclei
Dentate (lateral) nucleus
MAIN SECTION CB
Deep Nuclei and Movement
MAIN SECTION CB
Nuclear Functions/Lesions
Nucleus Input Function Lesion results in…
Fastigial (medial) Vestibular Control upright stance Falls to the side of the
against gravity lesion
Globose/ Cerebral cortex Balance agonist and Ipsilateral action tremor
emboliform Spinal cord antagonist muscles at a during voluntary
(interposed) single joint movements (e.g. reaching)
Dentate (lateral) Cerebral Cortex (1) Combined digit (1) Incoordination of digits
movements (2) Overshoot targets in
(2) Arm/leg reaching to reaching with arm/leg
a visual target
MAIN SECTION CB
Cerebellar Connections
red nucleus
vestibular
nuclei
reticular
formation
MAIN SECTION CB
Autonomic Nervous System
• Efferents/Afferents
• Circumventricular Organs
• Functions
– Baroreceptor
– Respiration
– Micturition
• Periaqueductal Gray (PAG)
MAIN
Viscero-Motor Efferents / Visceral Afferents
Sympathetic Efferents
• Output arises from the intermediolateral (IML) cell column from T1 to L2
• Relay through sympathetic trunk
Parasympathetic Efferents
• Sacral output
– From cells similar to the IML in the sacral cord
– Relays through ganglion cells in the pelvic plexus
• Cranial output
– Runs in CN III, CN VII, CN IX, CN X
– Arises in nuclei associated with the CNs
Visceral Afferents
• Return to the CNS with sympathetic & parasympathetic efferent fibers
• Cell bodies are in dorsal root or CN ganglia
• Sympathetic afferents: Pain (synapse on cells of spinothalamic tract)
• Parasympathetic afferents: State of the viscera
– CN VII, CN IX, CN X
MAIN SECTION
CN III Parasympathetics
Pupillary Constriction and Accommodation
Edinger-Westphal nucleus
to pupilloconstrictor
and ciliary muscles
CN III nucleus
CN III
ciliary ganglion
MAIN SECTION
CN VII and IX Parasympathetics
Viscero-motor
• Parasympathetic fibers in CN VII and IX arise from
“salvatory/lacrimal nuclei”
– Scattered cells in the pons and upper medulla
– Relay through submandibular, pterygopalatine, otic ganglia
• Responsible for secretion from salvatory glands, lacrimal gland, and
other glands in mouth and nasal cavity
Visceral afferents
• Synapse in the nucleus of the solitary tract
• CN VII: Taste info
• CN IX: Info from carotid body/sinus, pharynx
MAIN SECTION
CN X Parasympathetics
dorsal nucleus of CN X nucleus of the solitary tract GUT
HEART
nucleus ambiguus
PHARYNX/
= secretomotor efferents LARYNX
= vasomotor efferents
= visceral afferents
MAIN SECTION
Circumventricular Organs
nucleus of the
solitary tract
area postrema
CN XII
nucleus
nucleus of the
solitary tract
caudal
ventrolateral
medulla
nucleus
ambiguus
tonic
intermedio-
lateral column
peripheral arterioles
MAIN SECTION
Respiration = excitatory
= inhibitory
Lung stretch receptors
Carotid body chemoreceptors Forebrain Intrinsic chemoreceptors
MAIN SECTION
= afferent
Micturition
= efferent
Hypothalamus, PAG
bladder
MAIN SECTION
= afferent
Micturition
= efferent
Hypothalamus, PAG
bladder
MAIN SECTION
= afferent
Micturition
= efferent
Hypothalamus, PAG
bladder
MAIN SECTION
Periaqueductal Gray (PAG)
• Integrates several autonomic reflexes
PAG
MAIN SECTION
Eye Movements / Ocular Dominance
Keep the fovea on a visual Smooth pursuit Hold image of a moving target on the fovea
target (volitional control)
Vergence Adjust the eyes for viewing distances in depth
(converge for near, diverge for far)
MAIN
CLICK Vestibulo-Ocular Reflex (VOR)
If the head moves left quickly, VOR causes the eyes to move right.
vestibular
semicircular
nuclear
canal
complex
MAIN SECTION
Optokinetic Reflex
• Senses motion of the visual background
(involves the extrastriate cortex)
• Nystagmus
– Slow phase: Compensatory tracking movements
(smooth pursuit)
– Fast phase: Anticipatory fast movement to reposition
eyes after they reach the edge of the orbit (saccade)
Eye position (degrees)
Time (sec)
MAIN SECTION
Ocular Dominance Columns (ODCs)
• Features of ODCs
– Located in V1
– Develop prenatally
– Visual input to each ODC is monocular (by looking out of one
eye, you drive just one set of ODCs)
ZONE STRUCTURE(S)
Periventricular nucleus
PVZ Arcuate nucleus
Paraventricular nucleus
(not shown)
Dorsomedial nucleus
MHA Ventromedial nucleus
fornix
LHA Lateral hypothalamic area
OTHER
Supraoptic nucleus
Suprachiasmatic nucleus (not shown) median eminence
MAIN
Hypothalamic Nuclei
paraventricular nucleus
lateral
hypothalamic
area
fornix ventromedial
nucleus
fornix
arcuate
orexin cells? nucleus
median eminence
median eminence
MAIN SECTION
Hypothalamic Nuclei
anterior commissure
anterior
hypotha-
lamic area
fornix
median eminence
MAIN SECTION
Hypothalamic Nuclei
paraventricular nucleus
dorsomedial
nucleus
lateral
hypothalamic
area ventromedial
nucleus
fornix
optic tract
arcuate
nucleus
(dopa-
minergic
median eminence cells)
MAIN SECTION
Inputs to Hypothalamus
MAIN SECTION
Outputs from Hypothalamus
MAIN SECTION
Anterior Pituitary
median periventricular
eminence zone of the
hypothalamus
(arcuate nucleus and
part of the paraven-
tricular nucleus)
Hypothalamic cell
axons terminate in the
median eminence and
secrete hormones into
the fenestrated pituitary CRH
portal capillaries TRH hypothalamic
GnRH releasing
GHRH
Somatostatin hormones
Dopamine
ACTH corresponding
TSH
LH/FSH anterior
GH pituitary
GH/TSH hormones
MSH
MAIN SECTION
Posterior Pituitary
supraoptic nucleus /
paraventricular nucleus
median
eminence
Hypothalamic cell
axons terminate in the
posterior pituitary and
secrete hormones into
the fenestrated pituitary Posterior pituitary hormones:
capillaries
- oxytocin
- ADH (vasopressin)
MAIN SECTION
The hypothalamus regulates…
• Body temperature
• Body weight
• Ionic balance
• Blood pressure (chronic)
• Circadian rhythm
• Reproduction
• Response to stress
MAIN SECTION
inputs
outputs/effects
Body Temperature
releasing hormone neurons
spinal cord
anterior hypothalamus
reticular formation
TSH, GH, somatostatin
lateral hypothalamus
autonomic nuclei
outputs/effects
Body Weight
viscera (gut)
food intake, gut distension autonomic nuclei
NTS / parabrachial
nuclei
pituitary
tongue
taste
NTS
olfactory cortex
smell
outputs/effects
Ionic Balance
circumventricular
organs
blood osmolality, peptide hormones
NTS
outputs/effects
Blood Pressure (Chronic)
posterior pituitary
angiotensin II
ADH
circumventricular
organs vasoconstriction,
anti-diuretic action
on kidney
NTS vasoconstriction
outputs/effects
Circadian Rhythm
suprachiasmatic nucleus
couple the
circadian rhythm to
retina
the light/dark cycle
The suprachiasmatic nucleus of the hypothalamus (and the surrounding region) sets the circadian rhythm.
Input from the retina allows the cycle to be coupled to the light/dark cycle.
outputs/effects
Reproduction
gonadal steroids
olfactory
system reproduction
amygdala /
hippocampus
emotion, memory
outputs/effects
Response to Stress
CRH
ascending ACTH
catecholamine
systems glucosteroid release
from adrenal cortex
limbic system
change glucose
metabolism and
energy use
anterior
fornix
commissure
orbital/medial
prefrontal cortex
hippocampus
hypothalamus
amygdala
dentate gyrus
mammillary body
parahippocampal gyrus
MAIN
Amygdala
nucleus basalis of Meynert
central nucleus
Dorsal nuclei
medial nucleus
basal nucleus
amydala
Deep nuclei
accessory
basal nucleus PAC
Role
Inputs/Outputs
PAC = periamygdaloid complex
MAIN SECTION
The amygdala is involved in…
• Making cortical cells more responsive to other synaptic
inputs
– Most cells of the amygdaloid nuclei are cholinergic
– Help activate (desynchronize) cortex during waking state
• Fear conditioning
– Modulate brainstem reflexes in response to emotional status
outputs/effects
Inputs/Outputs
Amygdala
autonomic cell groups
ascending sensory lateral hypothalamus, PAG,
parabrachial nucleus, NTS, dorsal
system nucleus of CN X, ventrolateral medulla
visual, olfactory, auditory,
somatosensory
influence HR, BP,
MAJOR SHORTCUT
gut/bowel/respiratory/
bladder function, etc.
thalamic relay
nucleus
primary sensory
cortex
orbital/medial
secondary posterior prefrontal cortex
association intralaminar
cortex thalamic nuclei
determine whether
sensory stimulus is
rewarding or
The shortcut afferent pathway produces your initial “gut reaction” to a potentially aversive; set mood
threatening situation, before the major pathway kicks in.
glomerular formations
mitral cells
granule cells
Mitral cells
• Principal relay cells
• Dendrites extend to the glomerular formations and synapse with olfactory receptor
neurons (reciprocal, dendritodentritic synapses)
Granule cells
• Deep
– Processes interact with mitral cell dendrites in the external plexiform layer
– GABAergic
• Superficial
– Synapse with mitral cell dendrites
– GABA (most), dopamine, neuropeptides (enkephalin, substance P, neurotensin)
MAIN SECTION
Olfactory Cortex
putamen
• At the junction of frontal and lateral striate
temporal cortices nucleus accumbens / arteries
olfactory tubercle
• Axons of mitral cells run in
olfactory tract to primary
olfactory tract
olfactory cortex
MAIN SECTION
Olfactory Cortex
putamen
• At the junction of frontal and lateral striate
temporal cortices nucleus accumbens / arteries
olfactory tubercle
• Axons of mitral cells run in
olfactory tract to primary
olfactory tract
olfactory cortex
MAIN SECTION
Hippocampus
tail of
caudate
Role
dentate gyrus
CA3
pre-subiculum
Inputs/Outputs
para-
CA1 subiculum
subiculum
Information Flow
inferior temporal area
entorhinal
cortex
Alzheimer’s Disease
MAIN SECTION
The hippocampus is involved in…
• Memory processing (especially for spatial orientation)
– Hippocampal “place cells” fire when animal is in a particular spatial
location, related to surrounding sensory stimuli
• Kluver-Bucy Syndrome
– Associated with temporal lobe ablation
– Cannot recognize the significance of objects; loss of fear; failure to learn
• Alzheimer’s Disease
outputs/effects
Inputs/Outputs
Hippocampus
hypothalamus
info from
multisensory
association cortical
areas prefrontal / cingulate
visual, auditory areas of inferior cortical areas
and superior temporal cortex
perirhinal/entorhinal
cortex
basal ganglia
(ventral)
to the
neocortex
DG
ParaSub
PreSub
Sub
CA1
EC
tangles (intracellular)
• Entorhinal cortex and CA1 are severely damaged during early Alzheimer’s
– High amounts of tangles in these areas
• Tangles develop before plaques, but plaques mark beginning of the disease
– Plaques are prevalent in the cerebral cortex outside the hippocampal formation
hypothalamus, PAG
assessment of food
control visceral
functions
reward/aversion
appropriate
choices
control
of mood
multimodal amygdala /
inputs
sensory inputs hippocampus
outputs/effects
MAIN SECTION
Sleep
• Electroencephalogram (EEG)
• Stages
• Ascending Reticular Activating System
MAIN
Electroencephalogram (EEG)
MAIN SECTION
Stages of Sleep
MAIN SECTION
Ascending Reticular Activating System
Nucleus basalis of Meynert (ACh) [not shown]
- Implicated in sleep and wakefulness
- Projects to all parts of forebrain except basal ganglia
- Histology
MAIN SECTION
Ascending Reticular Activating System
RAT BRAIN – Stained for GABA
Nucleus basalis of Meynert (Ach) [not shown]
- Implicated in sleep and wakefulness
- Projects to all parts of forebrain except basal ganglia
- Histology
* The ACh input here is responsible for the paradoxical situation in REM sleep.
Add ascending
Remove ACh,ACh,
ascending NE, NE,
5-HT5-HT
inputinput
CORTEX
released RN bursting
RN inhibition of TRN is blocked
respondrespond
TRN cells cannot to sensory input with
to sensory input
a tonic
and firefiring pattern (
in a rhythmic wakefulness)
bursting pattern thalamocortical
( sleep spindles in early sleep stages) neuron
RETICULAR
NUCLEUS
THALAMIC
RELAY
ACh
NUCLEUS
NE (TRN)
5-HT
= Excitatory (glutamate)
= Inhibitory (GABA)
sensory afferents
eye, spinal cord, etc.
MAIN SECTION SYS
Memory
Types of amnesia
• Anterograde
– Inability to form new memories post-trauma
– May be able to form short-term working memories (minutes), but
cannot hold them
• Retrograde
– Loss of memories from a few seconds to a couple years pre-trauma
– May have more distant memories
MAIN
Implicit Memory
Procedural
• Subconscious
– Skills/procedures/habits
– Simple classical conditioning
• Learned by repetition
• Examples: riding a bike, playing an instrument
• Brain regions involved:
– Striatum, cortex, cerebellum
– Not the hippocampus
MAIN SECTION
Explicit Memory
Declarative
• Conscious
– Episodic: places and events
– Semantic: names and facts
MAIN SECTION
Working Memory
MAIN SECTION
Korsakov’s Syndrome
• Lack of vitamin B1 damage along 3rd ventricle
– Seen in alcoholics due to vitamin deficiency
• Presentation
– Anterograde amnesia
– Patients do not have a good awareness of their amnesia (unlike patients
with medial temporal lobe lesion)
• Involves the mammillary bodies, dorsal thalamus, anterior thalamus
NORMAL KORSAKOV’S
3rd ventricle
MAIN SECTION
Lewy Body Dementia
• Closely related to Parkinson’s Disease
• Intracellular inclusions of protein α-synuclein
neuronal dysfunction
• Dementia is similar to that found in Alzheimer’s
Lewy bodies
MAIN SECTION
Language Processing
CODES: Aphasia
• Visual / orthographic
• Auditory / phonological Note: This is not a thorough treatment of language
• Syntactic / grammatical processing, but these are the only questions I’ve
seen on past exams…
• Semantic / meaning
• Articulatory / speech motor planning
MAIN
Aphasia
Loss or impairment of language function (caused by brain damage) during
speech, hearing, reading, or writing
MAIN SECTION
Broca’s Aphasia
• Aphasia with difficulty in language expression
• Caused by lesion to the left frontal lobe
– Note the proximity of Broca’s area to the motor cortex, specifically
the region controlling the mouth and lips
control of mouth/lips
MAIN SECTION
Wernicke’s Aphasia
• “Receptive aphasia” with language comprehension difficulty
• Caused by lesion to the left posterior temporal lobe
– Note the proximity of Wernicke’s area to the auditory cortex
MAIN SECTION