Neuroscience

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HISTORY OF NEUROSCIENCE

SEARCH FOR SEAT OF MIND


Ancient
WHAT IS THE SEAT OF COGNITION?

• Trepanning done in South


America over 10,000 years

• To let the bad spirit out that


tormented the brains
SURGICAL PAPYRUS: 1600BC

• 30 Clinical cases of head


and surgical trauma
• first known descriptions of
cranial sutures, the external
brain surface.
ALCMAEON OF CROTON (500 BC)

•Brain as the site of sensation


BRAIN VS. HEART
Hippocrates 460-377 BC,
“Men ought to know that from the
brain and from the brain only arise
our pleasures, joys, laughter and
jests, as well as our sorrows, pains,
grieves and tears”.

Aristotle 384-322 B.C


“the heart as the organ of thinking, of
perception and feelings,”
“brain could cool the passion of heart”

387 B.C. - Plato teaches at


Athens. Believes brain is seat of
mental process
HEROPHILUS - 335-280 BC
Father of Anatomy
Ventricles are seat of
human intelligence
VENTRICULAR PNEUMATIC DOCTRINE
brain functions were
carried out in the
cerebral ventricles by
animal spirit.
GALEN 130-200 AD

177 - Galen lecture On the Brain


VENTRICLE THE SEAT OF MIND
Soul could not be
localized but mind
could
First ventricle the
common sense
Second - reason,
thinking and wisdom
Third - Memory

Nemesius (circa 320),


bishop of Emesa
LEONARDO DA VINCI APRIL 15, 1452 - MAY
2, 1519
ANDREAS VESALIUS (1514-1564 CE)
WILLIAM GILBERT - 1600 ELECTRICITY
GALILEO GALILEI 1564-1642
DESCARTES 1596-1650

1649 - Rene Descartes describes pineal as control center of


body and mind
SIR ISAAC NEWTON 1643-1727
1664 - THOMAS WILLIS

1664 - Publishes Cerebri anatome (in Latin)


1681 - coins the term Neurology
Reflex word was first used to described element act of NS
Chemistry is the basis of human function not mechanical
CEREBRI ANATOME - THOMAS WILLIS
BIOELECTRICITY

1791 - Luigi Galvani publishes work on electrical


stimulation of frog nerves
1809 - Luigi Rolando uses galvanic current to stimulate
cortex
1809 - LUIGI ROLANDO

Conluded - cerebrum controlled voluntary body functions and the


cerebellum controlled involuntary functions.
1825 - JEAN-BAPTISTE BOUILLAUD
Presents cases of loss of
speech after frontal lesions
from clinicopathological
correlation.

Frontal lobe and higher mental functions


JOHN HUGHLINGS JACKSON (1835-

•Clinicopathological correlation
•Seizure origin from cortex not medulla due to electrical activity
•Speech difficulty during seizure due to left post frontal injury
HISTORICAL REVIEW OF MOTOR CONTROL
Hughling Jackson 1858
Three level of
organization
Spinal/brain stem
Frontal
Prefrontal
CHARLES DARWIN 1808-1882
DISCOVERY OF NEURON

Ramony Cajal and Camillo Golgi 1906 Noble


1906 - SIR CHARLES SCOTT SHERRINGTON
1906- The Integrative
Action of the Nervous
system that describes
the synapse and motor
cortex
Spinal reflex
1932 Nobel Prize
1957 - W. PENFIELD
CORTICAL LOCALIZATION
E

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