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Osteogenesis Imperfecta (OI) by Ahmad Ichwan Lutfi
Osteogenesis Imperfecta (OI) by Ahmad Ichwan Lutfi
Pembimbing
dr.Widyatmiko A Putro ,SpOT
Osteogenesis Imperfecta /OI ??
Osteogenesis Imperfecta :
Diagnosis and Treatment
from Journal of the American
Academy of Orthopaedic Surgeon
• Osteogenesis imperfecta is a heritable
disorder characterized by extremely fragile
bones, blue sclerae, dentinogenesis
imperfecta, hearing loss and scoliosis
-Hearing loss
Classification
Silence et al
Type I Mildest form, lifelong blue sclera,
inheritance is autosomal dominant
Type II Lethal
Type III Severe,
• Result ;
-bone density increased
-patient younger than 3 years seemed to respond to
treatment more quickly than did older childre
-bone pain dissapeared
-fracture rate disssapeared
Ostenonecrosis of the jaw (ONJ)
• Is a condition associated with bisphosphonate
therapy