What is the Idiopathic Intracranial Hypertension

Treatment Trial?
Who was included in the trial?
What did the trial conclude?
What was new or unusual about the findings?
• First placebo controlled trail
• The beneficial effects of acetazolamide and diet are independent.
• moderate to severe optic nerve swelling recovered substantially more
vision than those with mild swelling.
• Acetazolamide has its greatest effect on visual field function and
papilledema in the first month of escalating dosage
• Treatment failure was much less common in the acetazolamide-plus-diet
group
• Many IIHTT subjects tolerated maximal dosages of acetazolamide up to
four grams per day.
• Doesn’t require potassium supplementation.
How should we apply the findings to patient
management?