Question Based Discussion 4

Ilma Syifannisa
113170037
 Case
A 62-year-old presents with angina. He has
beeen genotyped for a panel of drug
metabolism enzymes. His results reveal a
mutation in CYP2 gene with a warning that poor
metabolizers (PMs) may have lack of therapeutic
effect of Clopidogrel, resulting from failure to
generate the active form of the drug
• Why individual response to a particular drug
can be different?
• Explain the drug polymorphism
• Explain the personalized medicine
 Drug
metabolism

Steroid Cytochrome Cholesterol

synthesis P450 synthesis

Lipid
synthesis
CYP2A6 gene
cytochrome P450 family 2 subfamily A member 6

• Location: 19q13.2
• encodes a member of the cytochrome P450
superfamily of enzymes
CYP2B6 gene
cytochrome P450 family 2 subfamily B member 6

• Location: 19q13.2
 Drug Polymorphism
is the ability of a solid material to exist in more
than one form or crystal structure
• Crystalline polymorphs have the same
chemical composition, but different internal
crystal structures
poor aqueous poor Drug particle
solubility bioavailability size reduction
 Why solubility is important?

Solubility is the ability of a

must dissolve in order to
solute to dissolve in a
be absorbed through
solvent to form a
membranes and reach the
homogeneous solution of
site of action
thesolute in the solvent