Professional Documents
Culture Documents
Tissue Perfusion
Tissue Perfusion
1. BLOOD LACTATE
2. MIXED VENOUS OXYGEN SATURATION
3. TISSUE Pco2 MONITORING (TONOMETERY)
4. NEAR INFRARED SPECTROSCOPY
(OPTICAL MONITORING METHODS)
BLOOD LACTATE
• HISTORY
• LACTATE METABOLISM
• MEASUREMENT OF LACTATE
• HYRELACTATEIMA AND CAUSES
• LACTATE IN SEPSIS
HISTORY
• 1922: Otto Meyerhoff and Archibald V. Hill win
Nobel prize for energy capabilities of
carbohydrate metabolism
• Accepted that lactate production causes
acidosis
HISTORY
• Late 1950s: Huckabee established:
Hypoperfusion → Lactic Acidosis
• Recent focus has shifted away from this approach due to the
introduction of error by estimating intra mucosal bicarbonate from
serum bicarbonate.
Limitations-
1. Sensor can be applied only to skin that does not have hair
follicles ( leaves several area of brain unmonitored)
2. Electrical interphase- electrocautry - interfere with the
reading