ENZYME

STRUCTURE QUESTION

Presented by Group H4
- ORGANIZATION OF CHEMISTRY OF LIFE IN
METABOLIC PATHWAY
- FORMS OF ENERGY
 Energy released from the downhill reaction of __________
can be stored and the used to drive up the uphill reaction of
__________ .
 Anabolic pathway are sometimes called breakdown pathway.
( True / False )
 Enzyme work by lowering the __________ of a reaction.
 In order to complete the work, energy is required and must
be converted from chemical potential energy into
__________ .
-COFACTORS

 The complete active enzyme with its cofactor is called a

__________ .
 Cofactors can be grouped into __________ , __________
and __________ .
 Enzymes that have prosthetic groups are also called
__________ .
-FEEDBACK

 In feedback inhibitions, the products are act as an inhibitor of

an enzyme.
( True / False )
 In feedback inhibition, a metabolic pathway is switched off by
the __________ binding of its __________ to an enzyme
that acts early in the pathway.
 Feedback inhibition will not prevents the cell from wasting
chemical resources.
( True / False )
- ACTIVITION ENERGY BARRIER
- HOW ENZYMES LOWER THE EA BARRIER

 An enzyme is a macromolecule that act as a __________

that speed up reaction by __________ the activation energy.

EA

Question 2 and 3 based on the E A

 To reach the transition state, reactant molecules must

__________ energy from their surrounding.
 After the bond have broken, it __________ to the
surrounding
- ALLOSTERIC ACTIVATION AND INHIBITION
- IDENTIFICATION OF ALLOSTERIC REGULATORS

 The binding of an __________ to allosteric site stabilize the

shape that functional active site, while an __________
stabilize inactive form.
 Allosteric inhibitor is a substrate molecule that binding to one
active site which can stimulate the catalyc powers of a multi
subunit enzyme by affecting the other active site.
( True / False )
 The substrate that bind to allosteric site is called
__________ .
- FIRST AND SECOND LAW OF
THERMODYNAMICS

 Thermodynamics are the study of __________ .

 Based on the first law of thermodynamics, plants is the
energy producer.
( True / False )
 Some energy will become __________ during the transfer of
energy and transformation of energy. It is in the form of
__________ . This transfer and transformation of energy will
increase the __________ .
- SUBSTRATE SPECIFICITY OF ENZYME
- CATALYSIS IN THE ENZYME ACTIVE SITE

 In most enzymatic reactions, the substrate is held in the

active site by so called weak interaction, such as
__________ and __________ .
 At some point when all the enzymes have their active site
being occupied, the enzyme is said to be __________. To
increase the rate of product formation the action to be take is
to __________ .
 __________ brings chemical groups of the active site into
position that enhance their ability to __________ .