Transport of Oxygen and Carbon

Dioxide
FRESHMEN YEAR PROGRAM MEDICAL
SCHOOL UNIVERSITAS PADJADJARAN
Oxygen Content of Systemic Arterial
Blood at Sea Level
 1 L arterial blood contain
3 ml O2 physically dissolved (1.5%)
197 ml O2 bound to Hemoglobin (98.5%)
Total 200 ml O2
Cardiac output = 5 L/min
O2 carried to tissue/min = 5L/min x 200 ml O2/L
= 1000 ml O2/min
 Hemoglobin and Oxygen Partial
Pressure
 O2 – Hb dissociation
curve at normal body
temperature
 As pO2 increase,
more O2 combines
with hemoglobin
 Hemoglobin saturation and pH
 The effect pH on
affinity of
hemoglobin for
oxygen
 As pH decrease, the
affinity of
hemoglobin for O2 is
less, so less O2
combines with
hemoglobin and
more is available to
tissue
 Hemoglobin Saturation and PCO2
 As pCO2
increase , the
affinity of
hemoglobin for
O2 decrease
 Hemoglobin saturation and
Temperature
 As temperature
increase, the affinity of
hemoglobin for O2
decreases
 Fetal Hemoglobin
 Oxygen –
hemoglobin
dissociation curve
comparing fetal
and maternal
hemoglobin
 Fetal Hb has a
higher affinity for
O2 than does
adult Hb
TRANSPOR OF HYDROGEN IONS
BETWEEN TISSUES AND LUNGS
 Hypoxia
 Hypoxic hypoxia
 Low pO2 in arterial blood: high altitude, airways obstruction,
fluid in lung
 Anemic hypoxia
 Low Hb: hemorrhage, anemia, CO poisoning
 Stagnant (ischemic) hypoxia
 Low tissue blood flow
 Histotoxic hypoxia
 Tissue unable uses O2 properly
Carbon Dioxide Transport
1. Dissolved CO2: 7% dissolved in plasma

2. Carbaminohemoglobin

Hb + CO2 HbCO2
3. Bicarbonate ions
CO2 + H2O H2CO3 H+ + HCO3-
Carbon Dioxide Transport (cont)
Carbon Dioxide Transport (cont)
Summary of Gas Exchange and Transport in Lung and Tissue
Thanks for Your Attention