INTRODUCTION TO

INTERVERTEBRAL DISC ANATOMY,

PIVD (LUMBAR) AND ITS
MANAGEMENT

Presented by:

Dr. Ben Tungoe

PG, M.S(Orthopedics)
Central Institute of Orthopedics
VMMC & Safdarjung Hospital
New Delhi ,
 ANATOMY OF INTERVERTEBRAL DISC
• fibro cartilaginous structure.

• contributes 25% of the height of spinal column.

• function of shock absorption, transmitting compressive loads between vertebral bodies.

• Composed of the central nucleus pulposus(NP), the peripheral annulus fibrosus(AF) and
the end plates(EP).

• The end plate is a bilayer of cartilage that separate the IVD from the vertebral
body(VB) and serves as growth plate for the VB.
 NUCLEUS PULPOSUS:
– Highly hydrated structure, approx.
88% water

– Hydrophilic matrix: composed of

proteoglycans(PG) interspersed
within an irregular mesh of type-2
collagen and elastin fibers.

– The proteoglycans have a large

number of anionic
glycosaminoglycans(GAG) side
chains i.e chondroitin sulfate and
keratan sulfate which allows the
nucleus to imbibe water.

– Low collagen and high PGratio.

– Characterised by compressibility.
 ANNULUS FIBROSUS

-composed of concentric rings/lamellae of highly

organised Type-1 collagen fibres which are
interwoven.

-high collagen and low PG ratio

-the fibres are oriented 60 degree to the vertical

axis of spine and parallel within each lamella and
perpendicular between adjacent lamallae.

-lamallae are thicker anteriorly and laterally and

thinner posteriorly

-AF functions to contain the NP and maintain its

pressurization under compressive loads.

-characterized by extensibility and tensile strength

 BLOOD AND NERVE SUPPLY

• Blood Supply
– the disk is avascular with capillaries terminating at
the end plates
– nutrition reaches nucleus pulposus
through diffusion through pores in the endplates
• annulus is not porous enough to allow
diffusion

• Innervation
– the dorsal root ganglion gives rise to the
sinuvertebral nerve which innervates
the superficial fibers of annulus
• no nerve fibers extend beyond the superficial
fibers
– neuropeptides thought to participate in sensory
transmission include
• substance P
• calcitonin
• VIP
• CPON
Distribution of load in the
inter-vertebral disc.

(A)In the normal, healthy disc, the

nucleus distributes the load equally
throughout the annulus.

(B)As the disc undergoes

degeneration, the nucleus loses some
of its cushioning ability and transmits
the load unequally to the annulus.

(C)In the severely degenerated disc,

the nucleus has lost all of its ability to
cushion the load, which can lead to
disc herniation.
 Disc Biomechanics
• Disc
– viscoelastic characteristics
• demonstrates creep which allows for deformity over time
• demonstrates hysteresis which allows for energy absorption with repetitive axial
compression
– this property decreases with time
• Stresses
– annulus fibrosus
• highest tensile stresses
– nucleus pulposus
• highest compressive stress
– Intra-discal pressure is position dependent
• pressure is lowest when lying supine
• pressure is intermediate when standing
• pressure is highest when sitting and flexed forward with weights in the hands
• when carrying weight, the closer the object is to the body the lower the pressure
• Stability
– following subtotal discectomy, extension is most stable loading mode
 Pathoanatomy
• Disc Herniation
– herniated disks are associated with a spontaneous increase in the productionof
• osteoprotegrin (OPG)
• interleukin-1 beta
• receptor activator of nuclear factor-kB ligand (RANKL)
• parathyroid hormone (PTH)

• Disc aging leads to an overall loss of water content and conversion to fibrocartilage. Specifically thereis
– decrease in
• nutritional transport
• water content
• absolute number of viable cells
• proteoglycans
• pH
– increase in
• an increase keratin sulfate to chondroitin sulfate ratio
• lactate
• degradative enzyme activity
• density of fibroblast-like cells
– fibroblast-like cells reside in the annulus fibrosus only
– no change in
• absolute quantity of collagen
SPECTRUM OF DEGENERATIVE JOINT
DISEASES OF SPINE

• Internal disc disruption

• Disc herniation
• Degenerative spondylolisthesis
• Spinal stenosis
• Adult spinal deformities
 Spectrum of changes(Kirkaldy Willis Concept)
Internal disc disruption

Disc herniation

Intervertebral space decrease

Overloading of facet joints, ligamentous instability

Instability of motion segment

Degenerative spondylolisthesis

Attempt to stabilise by formation of osteophytes and ligaments hypertrophy

Spinal stenosis

Adult spinal deformity

Etiology of Intervertebral disc degeneration
Repetitive mechanical activities – Frequent bending, twisting, lifting, and other similar
activities without breaks and improper stretching

Living a sedentary lifestyle – more prone to herniated discs because the muscles that
support the back and neck weaken, which increases strain on the spine.

Traumatic injury to lumbar discs- commonly occurs when lifting while bent at the
waist, rather than lifting with the legs while the back is straight.

Obesity – overloading the motion segment.

Poor posture – Improper spinal alignment

Tobacco abuse – toxins reduces the disc’s ability to absorb nutrients, which results in the
weakening of the disc.

Mutation- in genes coding for proteins involved in the regulation of the extracellular
matrix, such as MMP2 and THBS2,
 Cellular and Biochemical Changes of the
Intervertebral Disc

 Decrease proteoglycan
content.
 Loss of negative charged
proteoglycan side chain.
 Water loss within the
nucleus pulposus.
 Decrease hydrostatic
property.
 Loss of disc height.
 Uneven stress
distribution on the annulus.
Thompson Grading( based on sagittal sections of
fresh cadaveric specimen)
Pfirmann Grading on MRI
MODIFIED PFIRMANN GRADING
MODIFIED PFIRMANN GRADING
Adam’s classification(based on discography)
 ANNULAR TEARS

Concentric tears :
circumferential lesions, involves
outer layers of the annular wall.

Radial tears:
characterized by an annular tear
which permeates from the deep central part of
the disc (nucleus pulposus) and extends
outward toward the annulus, in either a
transverse or cranial-caudal plane.

Transverse tears:
also known as “peripheral tears” or “rim
lesions,” are horizontal ruptures of fibers, near
the insertion in the bony ring apophyses.
L4-L5 CT diskogram
demonstrating a large left
posterolateral radial anular tear
associated with a left foraminal and
extraforaminal herniaton
 INTRAVERTEBRAL HERNIATIONS
Herniated discs in the cranio-caudal
(vertical) direction through a break in
one or both of the vertebral body
endplates are referred to as
“intravertebral herniations” (also
known as Schmorl’s nodes).

They are often surrounded by reactive

bone marrow changes.

Nutrient vascular canals may leave

scars in the endplates, which areweak
spots representing a route for the
early formation of intrabody nuclear
herniations
 PROLAPSED INTERVERTEBRAL DISC

• Mostly seen in lumbar region followed by cervical

region.
• Affects young adults 30-40 years who still have
relatively maintained disc height.
• Male:female ratio 3:1
• 95% involves L4-5 and L5-S1(most common)
• Herniates through the postero-lateral corner of annulus
fibrosus(thin region)
• Most commont causes:
– Sudden violent trauma (sports injuries)
– Less severe trauma in degenerated annulus(lifting,
bending, coughing, sneezing etc)
 Anatomic classification

Disc protrusion: the herniated portion of the disc covered

with a thin layer of annulus

Disc extrusion: disc material herniated through annulus but

remains continuous with disc space

Disc sequestration: the disc fragment herniates through the

annulus and loses contact with the originating disc space
Classification based on the location of
the disc herniation
• Posterolateral/paracentral prolapse:
– Commonest
– PLL weakest in this area
– Herniated disc impinges on the traversing
nerve roots(e.g the L5 nerve root in L4-5
disc prolapse)

• Central prolapse:
– may present with back pain only or Cauda-
equina(severe cases)

• Foraminal/extra foraminal/far lateral

herniation:
– Less common
– The herniated disc impinges on the exiting
nerve roots
(e.g. L4 nerve root in L4-5 level)
 Clinical features: History
• History of episode of trauma
• Radicular pain (buttock and thigh pain, extending below the knee
following the distribution of the involved nerve roots)
• aggravated by flexion, sitting, straining, sneezing, cough
• decreased by rest, especially in the semi-Fowler position
• Other symptoms:
– Weakness Corresponding to level of neurological involvement
– Paraesthesia in dermatomal distribution
– Cauda equina

• Natural course of symptomatic PIVD is slow resolution of

symptoms over 6-8 weeks period in 80% of cases
 Cauda Equina syndrome
• Emergency
– Aggressive evaluation and management
– Large central herniation
• Most consistent symptoms(Tay & Chacha)
– saddle anesthesia
– bilateral ankle areflexia
– bladder symptoms
• Other symptoms-
– numbness and weakness in both legs,
– rectal pain,
– numbness in the perineumBowel
disturbances
 Clinical Features- Signs
• Antalgic gait
– Affected hip more
extended and knee more
flexed than normal side
• Trendelenberg gait (L5
nerve root)
• List
– abrupt planar shift
– Axillary disc –same side
– Shoulder disc- opposite
side
• Thigh and calf muscle
wasting
• Loss of lumbar lordosis
• Paraspinal spasm- central
furrow sign
 Provocative tests
– straight leg raise
• a tension sign for L5 and S1nerveroot
• technique
– can be done sitting or supine
– reproduces pain and paresthesia in leg at 30-70 degrees hipflexion
• sensitivity/specificity
– most important and predictive physical finding for identifying who is a good
candidate for surgery
– contralateral SLR
• crossed straight leg raise is less sensitive but morespecific
– Lesegue sign
• SLRaggravated by forced ankle dorsiflexion
– Bowstring sign
• SLRaggravated by compression on popliteal fossa
– Kernig test
• pain reproduced with neck flexion, hip flexion, and leg extension
– Naffziger test
• pain reproduced by coughing, which is instigated by lying patient supine and
applying pressure on the neckveins
– Milgram test
• pain reproduced with straight leg elevation for 30 seconds in the supine position
SLUMP TEST
FLIP TEST
Clinical features -Neurology

L1 L2
Clinical Features- Neurology

L3
Clinical Features- Neurology

L4
 Clinical Features- Neurology

L5

Trendelen
berg test
Clinical Features- Neurology

S1
 Clinical Features- Red Flags

• Extremes of age(<15yr , >55yr)

• Neurological deficits
• Fever
• Unexplained weight loss(10lb in 6months)
• Malaise
• Rest pain/ night pain
• Significant trauma
• Drug and alcohol abuse
 Non Organic Signs Of Waddell

Described by Waddel in post op

patients

1. Non anatomic tenderness

2. Simulation sign

3. Distraction sign

4. Regional sensory or motor

disturbance

5. Overreaction(most
sensitive)
 Differential Diagnosis
SPINAL CAUSES:
-Trauma
-Infection: Osteomyelitis or discitis ( with nerve root pressure)
-Inflammation: Arachnoiditis, ankylosing spondylitis
-Neoplasm: Benign or malignant with nerve root pressure(multiple myeloma,
extradural tumors)

EXTRASPINAL CAUSES:

• Peripheral vascular disease

• Gynaecological conditions
• Orthopaedic conditions ( osteoarthritis of hip, Muscle related disease, Facet joint
arthropathy)
• Sacroiliac joint disease
• Neoplasm
• Peripheral nerve lesions
• Neuropathy (Diabetic, tumour, alcohol)
• Local sciatic nerve conditions (Trauma, tumour)
• Inflammation (herpes zoster)
 KEY DIAGNOSTIC POINTS
LUMBAR DISC PROLAPSE SPINAL STENOSIS
 Leg pain greater than back pain  Heaviness(no pain) develops after walks
 SLRT + a limited distance.

 Neurological deficit present  Flexion relieves symptoms

ANNULAR TEARS
 Back pain greater than leg pain
 Bilateral SLRT positive
FACET JOINTARTHROPATHY
 Localized tenderness present unilaterally Pain increases on prolonged muscle use
over joint
 Pain occurs immediately on spinal
extension
 Pain exacerbated with ipsilateral side
bending
 No neurological deficit
 SLRT -ve
MYOGENIC OR MUSCLE RELATED
 Pain localised to affected muscle
 Pain reproduced with sustained muscle
contraction against resistance
 Contralateral pain with side bending
 Investigations- Plain Radiographs

• FINDINGS:
– Loss of lumbar lordosis
– Loss of disc height
 X ray views

• AP and Lateral views

• Oblique views
– Spondylolisthesis and lysis
– Hypertrophic changes around foramina in cervicalspine
• Lateral flexion/ extension views
• Ferguson View
– 20 degrees caudocephalicAP
– fifth root compression by a large transverse process of the L5 vertebra
against the ala of the sacrum.
• Angled caudal views
– facet or laminar pathologicalconditions.
 X ray- Signs of Instability

• Indirect Signs
– Disc space narrowing,
– Sclerosis of end plates
– Osteophytes
– Traction spur
– Vacuum Sign
• Direct signs
– Translational abnormalities on dynamic films
 Vacuum sign
• radiolucent defect
• presence of nitrogen gas
accumulations in annular
and nuclear degenerative
fissures
• typical central vacuum
phenomenon gas
collection that fills large
neo-cavity occupying
both the nucleus an
annulus.
• indicative of advanced
disc degeneration.
 CT scan
Advantages:
• provides superior imaging of cortical and trabecularbone
compared with MRI.
• It provides contrast resolution and identify root compressive
lesions such as disc herniation.
• differentiate between bony osteophyte from softdisc.
• diagnose foraminal encroachment of disc material due to its
ability to visualize beyond the limits of the dural sac and root
sleeves.
Limitations
• cannot differentiate between scar tissue and new disc
herniation
• does not have sufficient soft tissue resolution toallow
differentiation between annulus andnucleus
 Investigations- MRI
• Most accurate and sensitive modality forthe diagnosis
of subtle spinalpathology.
• It allows direct visualization of herniated disc material
and its relationship toneural tissue including intrathecal
contents.
• Advantages over myelography
– No radiation
– Non invasive
– No intrathecal contrast
– More accurate in far lateraldisc
– Disc disease of LSjunction
– Early disc disease
Advantages of MRI over CT
– imaging the disc
– directly images neural structures
– shows the entire region of study (i.e.,cervical,
thoracic, or lumbar).
– ability to image the nerve root in the foramen
Limitations
– Showing abnormal anatomy in asymptomatic
patient.
– MRI findings can’t correlate with severityof
symptoms.
 Indications for MRI
• pain lasting > one month and not
responding to non-operative management
or
• red flags are present
– infection (IV drug user, h/o of fever andchills)
– tumor (h/o or cancer)
– trauma (h/o car accident or fall)
– cauda equina syndrome (bowel/bladder changes)
Massive lumbar disc extrusion at L5–S1 in a 44-year-old man. Sagittal(a)
and axial (b) T1-weighted images; sagittal (c) and axial (d) T2-weighted
images. The extruded disc compresses and displaces the right S1nerve
root. On the sagittal T1-weighted image, the continuity between the
extruding portion and the parent disc can clearlybe identified.
 GADOLINIUM ENHANCED CONTRAST MRI

-Investigation of choice for recurrent discprolapse

-it allows to distinguish between post surgical
fibrosis(enhances with gadolinium) and recurrent
herniated disc(doesn’t enhance with gadolinium)
 Myelography
• Unnecessary if clinical and CTor MRI findings are
in complete agreement.
• Indications
– suspicion of an intraspinal lesion,
– patients with spinalinstrumentation,
– questionable diagnosis resulting from conflicting clinical
findings and other studies .
– previously operated spine
– marked bony degenerative change that maybe
underestimated on MRI
– arachnoiditis
Air contrast is used rarely
-Only in situations in which the patient is extremely
allergic to iodized materials
 Discography- Uses
• Evaluate equivocal abnormality seen
on myelography, CT or MRI
• Isolate a symptomatic disc among
multiple level abnormality
• diagnose a lateral disc herniation
• establish discogenic pain
• select fusion levels
• evaluate the previously operated spine
– distinguish between mass effect
from scar tissue or disc material
 Electrodiagnostic studies
• Applied when clinical examination and imaging fail
to provide a clear diagnosis or perhaps conflicting
diagnoses
• May include needle electromyelography,
somatosensory evoked potentials or cervical root
stimulation
• May help differentiate primary cervical disorders
from peripheral nerve entrapments syndromes or
pain eminating from the intrinsic shoulder pathology
 MANAGEMENT
• NON OPERATIVE MANAGEMENT
– 90% respond to conservative management
– Rest in semi-fowler position,ice packs,
analgesics, muscle relaxants, oral steroids,
physical therapy and exercises
– Selective nerve root blocks: transforaminal SNRB
with local anesthetic agent and long acting
corticosteroid combination
– Lumbar epidural steroid injection
 Epidural Steroid injection
• Contraindications
– infection at the injection site
– systemic infection
– bleeding diathesis
– uncontrolled diabetes mellitus
– congestive heart failure.
• Complications
• Minor
– Non-positional headaches
– facial flushing insomnia
– low-grade fever,
– transient increased back or
lower extremity pain
• Major
– vasovagal reaction
– Dural puncture
– Positional headache
– epidural abscess,
– epidural hematoma,
– Dura-cutaneous fistula,
– Cushing syndrome
 Epidural Steroid
injection Techniques

• Interlaminar Approach

• Transforaminal Approach

• CaudalApproach
 Bed Rest
• no data to suggest that bed rest alters the
natural history of lumbar disc herniationor
improves outcomes.
• Consensus of 2 days (if used)

Semi Fowlers
Position
 Physical Therapy
• Excercises
• Back School
• Others : IFT, SWD, TENS, Traction
 Excercises

• Better than medical carealone

• Flexion-based isometric exercises appear to
have the most support in theliterature
• Offer benefit by decreasing local muscle
spasm and stabilizing the spine.
• Begin when acute pain diminishes
 Exercises
GENERAL RULES FOR EXERCISE
• Do each exercise slowly. Hold the exercise position for
a slow count of five.
• Start with five repetitions and work up to ten. Relax
completely between each repetition.
• Do the exercises for 10 minutes twice aday.
• Care should be taken when doing exercises that are
painful. A little pain when exercising is not necessarily
bad. If pain is more or referred to the legs the patient
may have overdone it.
• Do the exercises every day without fail.
 FORACUTESTAGE

BRIDGING EXERCISE KNEE HUGS

FOR RECOVERY OR SUBACUTE STAGE

EXTENSION CONTROL
HAMSTRING STRETCH

KNEE ROLLS
 Physical therapy
• TENS
– Trans-cutaneous electrical nerve stimulation
– release of endogenous analgesic endorphins
– Central nervous system process in which a control center is altered to
block transmission of pain
– Deyo RAet al ‘TENS is no different from a placebo’
• Intermittent Pelvic Traction
– Goal- distract the lumbar vertebrae.
– enlargement of the inter-vertebralforamen,
– creation of a vacuum to reduce herniateddiscs,
– placement of the PLLunder tension to aid in reduction of herniated
discs,
– relaxation of musclespasm,
– freeing of adherent nerveroots
– Does not alter naturalhistory of disease
 Lifestyle Modifications
• Avoidance of
– Repetitive bending /twisting/ lifting
– Contact sports
– Heavy weights
– 2wheelers, Auto rickshaws
– Soft mattress( Spring, foam)
• Posture training
• Back support while sitting
• Firm mattress (rubberised foam, coir)
Intra-discal Electrothermal Therapy
• Low back pain of discogenic origin
• Not useful in radiculopathy
• posterolateral placement of a probe around the inner
circumference of the annulus followed by heating ofthe
probe.
• Pre Requisites
– Normal neurology
– Negative SLR.
– absence of compressive lesions on MRI
– positive concordant discogram
• Conflicting outcomes requiring refinement of indications
 Operative management
• Standard discectomy
• Limited Discectomy
• Microsurgical Lumbar discectomy
• Endoscopic discectomy
• Additional Exposure
– Hemi laminectomy
– Total Laminectomy
– Facetectomy
• Percutaneous Discectomy
• Chemo-nucleolysis
• Arthrodesis
• Disc replacement
 SURGICAL MANAGEMENT
• Indications
– persistent disabling pain lasting more than 6 weeks that have failed non-
operative options (and epidural injections)
– progressive and significant weakness
– Cauda-equina syndrome

• Rehabilitation
– patients may return to medium to high-intensity activity at 4 to 6 weeks

• Outcomes: improvement in pain and function greater withsurgery

• Positive predictors for good outcome ofsurgery

– leg pain is chief complaint
– positive straight leg raise
– weakness that correlates with nerve rootimpingement seen on MRI
– married status

• Negative predictors for good outcome ofsurgery: worker’s compensation

 STANDARD DISECTOMY
• Prone position
• With bolsters
• Knee chest position
• Allows abdomen to
hang free,
– minimizing epidural
venous dilation and
bleeding
• Lateral position with
affected side up
 Salient Points
• Lamina exposed cephalad and caudad
to the level of the herniated disc
• 1-2 sq cm area of lamina removed
exposing dura and nerve root
• Visualise lateral edge of nerve root
• Remove sequestered disc
• Incise Annulus and remove central
and lateral part of nucleus
• Nerve root must freely move1cm
inferomedially
– Foraminotomy

• Free fat graft to reduce postop

scarring
 Far lateral microdiskectomy
• indications
– for far-lateral disc herniations
• technique
– utilizes a paraspinal approach of Wiltse
 Additional Exposure Techniques
• Large disc herniation, lateral recess stenosis or
foraminal stenosis, may require a greater
exposure of the nerveroot.
• If the extent of the lesion is known before
surgery, the proper approach can be planned
Hemilaminectomy
• required when
identifying the root is
a problem.

• Eg. Conjoined root

Total Laminectomy
• Reserved for patients
with spinal stenosIsthat
are central in nature,

• Occurs typically in cauda

equina syndrome.
 Facetectomy
• reserved for
– foraminal stenosis
– severe lateral recess stenosis

• If more than one facet is removed,a fusion

should be considered

• Especially in a young, active individual with a

normal disc height at that level.
Lumbar Microsurgical Discectomy
• first reported by Williams in 1978
• procedure of choice forherniated lumbar disc
• Decompression of the involved nerve rootwith
minimum trauma to theadjacent structures.
• Advantages
– decreased operative time,
– Decreased morbidity,
– less loss of blood,
– shorter stay in the hospital,
– earlier return to work.
– Visibility for assistant
Lumbar Microsurgical Discectomy
• Drawbacks
– inadequate exposure
– incomplete decompression
– Costly equipment
• Contraindications
– Previously operated
– Spinal Canal Stenosis
 Microsurgical Lumbar Discectomy
• Requirements
– operating microscope with a 400-mm lens,
– small-angled Kerrison rongeurs of appropriate
length,
– microinstruments,
– combination suction–nerve root retractor
Microsurgical Lumbar Discectomy
• Original Guidelines
– Avoidance of laminectomy and of trauma to the
facets,
– Preservation of all extraduralfat,
– Blunt perforation of the anulus fibrosus rather than
incision with ascalpel,
– Preservation of healthy, non-herniatedintervertebral
disc material,
– Remove only as much disc as is necessary to relieve
the neural elements from visible and palpable
compression.
• New Guidelines
– Subtotal discectomy through an incision, madewith
a scalpel,in the anulus fibrosus;
– using bipolar coagulation;
– Removing the medial portion of the facet for
exposure when necessary
 Percutaneous endoscopic Discectomy
• Mechanically decompress a
herniated lumbar disc via a
posterolateral cannula
• Reduced morbidity
• Reduced hospital stay
• No anaphylactic reactions and
neurological complications
associated with chemonucleolysis

Contraindications
– Presence of sequestered fragments
– Lumbar canal stenosis
– Lumbosacral discs
 Post op management
• Immediate post op
– Monitor neurology
– Turn in bed , semi fowler position
– Walk with assistance to toilet
– Oral analgesics and muscle relaxants for pain
– Bladder stimulants to assist invoiding
– Discharge- after walking and voiding(day of surgeryin
microscopic discectomy)
– minimize sitting and riding in a vehicle to comfort
– Increase walking on a daily basis
– Avoid stooping bending lifting
 Post op management
• Delayed
– Core strengthening between week 1 & 3
– Lifting bending stooping gradually after 3weeks
– Long trips avoid for 4-6weeks
– Walking jobs with minimal lifting 2-3weeks
– Prolonged sitting jobs 4-6 weeks
– Heavy labor, long driving 6-8weeks
– Exceptionally heavy manual labour- AVOID
 COMPLICATIONS
• Infection – Superficial wound
infection , Deep disc space infection
• Thrombophlebitis/ Deep vein
thrombosis
• Pulmonary embolism
• Dural tears may result in
Pseudomeningocoele, CSFleak,
Meningitis
• Postoperative cauda equine lesions
• Neurological damage or nerve root
injury
• Urinary retention and urinary tract
infection
 CHEMONUCLEOLYSIS

Chymopapain Degrades the Water holding

injected into the proteoglycans in the capacity of the disc
disc nucleus is decreased

Shrinkage of the
disc
 Chemo nucleolysis
• Contraindications
– Sequestered disc
– Spinal stenosis
– previous injection of chymopapain
– allergy to papaya or itsderivatives;
– Previous surgical treatment of the lumbarspine;
– herniation of more than twodiscs;
– a rapidly progressive neurological deficit;
– neurogenic dysfunction of the bowel or the bladder, or both;
– spondylohisthesis.
– Spinal tumour
– Pregnancy
– Diabetic neuropathy
 Chemo nucleolysis
• Complications
– Neurological
• cerebral hemorrhage,
• paraplegia,
• paresis, quadriplegia,
• Guillain-Barre syndrome,
• seizure disorder.
– Anaphylaxis
• Procedure is not in favournow
 Disc Excision & Arthrodesis
• First suggested by Mixter and Barr

• Indicated for
– Marked segmental instability
– Done when facets are destabilized bilaterally to prevent
Iatrogenic Spondylolisthesis

• Disadvantages of fusion:
– Alters the biomechanics of spine
– Loss of motion and overall shift in the sagittal alignment
– Causes degenerative changes in the adjacent spinal
motion segments
 Total Disc Replacement
• CHARITEartificial disc (Depuy spine) was the first
implant approved by FDAfor total disc
replacement in october 2004.
• Presently, there are only three lumbardisc
prostheses with FDAapproval:
– the INMOTION, which is a modification of theCharite
(Depuy Spine, Raynham, MA),
– the ProDisc-L (DePuySynthes),
– the activL (Aesculap, CenterValley,PA).

• All are approved only for single-level discreplacement.

ADVANTAGES OF DISC REPLACEMENT
• Removes the disc/presumed main source of
pain
• Restore disc height----relieves load across the
facet joints----improves the pattern of load
bearing between vertebrae.
• Segmental stability, preservation and
improvement of segmentalmotion
• Maintain lordosis curve
• Limit disability and early return to work
 PREREQUISITESFORDISC
REPLACEMENT
• Normal facet joints
• Good bone quality(non
osteoporotic)
• No spondylolisthesis or
spinal deformity
• No infection
• Single disc level
PRO DISC L
PRO DISC L
THANK YOU