ANTIMICROBIAL THERAPY

ARIES BUDIANTO
 Not differ fundamentally from
antimicrobial usage in general medicine
 The basic considerations:
- efficacy
- toxicity
- cost
 Principles of selection of
antimicrobial drugs
 The judgment, on the basis of clinical
impression
 Formulation of a differential diagnosis an
microbial pathogens
 Procurement of specimen likely to provide
a microbiologic diagnosis
 Selection of the drug most likely to be
effective againts the sus
 Observation of the clinical response to the
prescribed antimicrobial and laboratory
identification of putative microbial
pathogen
 Continuation of the empiric regimen or
switch to pathogen-directed therapy
 The Use of antibiotics in surgery

 Prophylactic antibiotics

 Theraupetic use of antibiotics:

- Empiric therapy
- definitive therapy
 Drug administration
 Route
 Duration
 Treatment failure -> wrong antibiotic, in
adequate dose, inappropriate route
 Drug toxicity