Patho CVS

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Myocardial Infarct

A heart attack (also known as


a myocardial infarction) is the
death of heart muscle from
the sudden blockage of a
coronary artery by a blood
clot.

Blockage of a coronary artery


deprives the heart muscle of
blood and oxygen,causing injury
to the heart muscle.

Injury to the heart muscle


causes chest pain and chest
pressure sensation.

Coronary arteries are


blood vessels that
supply the heart muscle
with blood and oxygen.
What causes Heart Attack?
Atherosclerosis is Atherosclerosis
a gradual
process by which
plaques
(collections) of
cholesterol are
deposited in the
walls of arteries.

The risk factors for


atherosclerosis and heart
attack include elevated
cholesterol levels, increased
blood pressure, tobacco Cholesterol plaques cause
use, diabetes, male gender hardening of the arterial
and a family history of heart walls and narrowing of the
attacks at an early age. inner channel (lumen) of
the artery.
ISCHAEMIC HEART DISEASE
• Defined as insufficient supply of oxygenated blood to
heart muscle.

• Due to narrowing of the heart arteries due to fatty


deposits which would eventually lead to heart attack.

• Common in men than women.

• Expected to be the most common cause of death by


the year 2020.

• Cause is normally due to high alcohol intake, fatty diet


and obesity.
HYPERTENSION !!!
Symptoms include:
• Shortness of breath (dyspnea), initially while exercising and eventually while at rest
• Fatigue
• Dizziness or fainting spells (syncope)
• Chest pressure or pain
• Swelling (edema) in your ankles, legs and eventually in your abdomen (ascites)
• Bluish color to your lips and skin (cyanosis)
Causes include:
• Blood clots in the lungs (pulmonary emboli)
• Chronic obstructive pulmonary diseases, such as emphysema
• Sleep apnea and other sleep disorders
• Congenital heart disease
• Sickle cell anemia
• Chronic liver disease (cirrhosis)
• Left-sided heart failure
Complications include :
• Thrombotic stroke , transient ischemic attack
• Congestive heart failure , myocardial infarction , angina pectoris
• Aortic dissection
• Renal artery stenosis
• Nephrosclerosis
Prevention include:
• Weight control
• Increased physical activity
• Increased potassium intake
• A dietary rich in fruits and vegetables and low-fat meat, fish, and dairy products
Classification of Congenital Heart Disease (CHD)
I) Malposition of heart - dextrocardia
- situs inversus
II) Shunts - a) left to right - acyanotic (VSD1, ASD2, PDA3,
Eisenmenger syndrome)

ASD

PDA
VSD

1
Ventricular Septal Defect
2
Atrial Septal Defect
3
Patent Ductus Arteriosus
- b) right to left - cyanotic (TOF4, Persistent truncus arteriosus, transposition of great
vessels)

Persistent truncus arteriosus Transposition of great vessels


TOF
III) Obstructive Congenital Heart Diseases
Coarctation of aorta
Aortic stenosis
Aortic atresia
Pulmonary stenosis
4
Tetralogy of Fallot

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