Tablets are solid pharmaceutical dosage forms prepared by compression or molding containing drug substances. Tablets have advantages like improved taste and appearance from coatings, accurate dosing as solid units, and customizable release profiles. Tablets consist of active drugs mixed with inert excipients like diluents, disintegrants, binders, glidants, lubricants, and flavors. Excipients are selected based on criteria like being nontoxic, available, inexpensive, stable with drugs, and color compatible.
Tablets are solid pharmaceutical dosage forms prepared by compression or molding containing drug substances. Tablets have advantages like improved taste and appearance from coatings, accurate dosing as solid units, and customizable release profiles. Tablets consist of active drugs mixed with inert excipients like diluents, disintegrants, binders, glidants, lubricants, and flavors. Excipients are selected based on criteria like being nontoxic, available, inexpensive, stable with drugs, and color compatible.
Tablets are solid pharmaceutical dosage forms prepared by compression or molding containing drug substances. Tablets have advantages like improved taste and appearance from coatings, accurate dosing as solid units, and customizable release profiles. Tablets consist of active drugs mixed with inert excipients like diluents, disintegrants, binders, glidants, lubricants, and flavors. Excipients are selected based on criteria like being nontoxic, available, inexpensive, stable with drugs, and color compatible.
Tablets are solid pharmaceutical dosage forms prepared by compression or molding containing drug substances. Tablets have advantages like improved taste and appearance from coatings, accurate dosing as solid units, and customizable release profiles. Tablets consist of active drugs mixed with inert excipients like diluents, disintegrants, binders, glidants, lubricants, and flavors. Excipients are selected based on criteria like being nontoxic, available, inexpensive, stable with drugs, and color compatible.
Tablets may be defined as solid pharmaceutical dosage forms containing
drug substances prepared either by compression or molding methods. Although it is possible to manufacture in a wide range of shape, official tablets are defined as circular sizes with either flat or convex faces. Advantages of Tablets 1. Organoleptic properties (taste, appearance and odor) are best improved by coating of tablet. 2. Accuracy of dose is maintained since tablet is a solid unit dosage form. 3. Tailor made release profile can be achieved. 4. Longer expiry period and minimum microbial spillage owing to lower moisture content. 5. As tablet is not a sterile dosage form, stringent environmental conditions are not required in the tablet department. 6. Ease of packaging (blister or strip) and easy handling. 7. Ease of product identification because of huge number of shapes and color. 8. Easy to transport in bulk. Emergency supply supplies can be carried by patients. Disadvantages of tablets 1. Drugs not absorbed or extensively degraded into GI tract cannot be made into tablets. 2. It is difficult to convert a high dose poorly compressible API into a tablet of suitable size for human use. 3. Difficult to formulate a drug with poor wettability, slow dissolution into a tablet. 4. Slow onset of action as compared to parenterals, liquid orals and capsules. 5. Difficult to swallow for kids, terminally ill and geriatric patients. Essential qualities of a good tablets. They should be accurate and uniform in weight. The drugs should be uniformly distributed throughout the tablets. The size and shape should be reasonable for easy administration. The tablets should not be too hard that it may not be disintegrate in the stomach. After administration it should disintegrate readily. They should be attractive in appearance. They should not have any manufacturing defects like cracking, capping or discoloration. Tablet excipients
Compressed tablets usually consist of active medicaments
mixed with a number of inert substances known as excipient or additives i.e. all non – drug components of a formula are termed excipients or additives. Although these additives are termed as inert but they have a great influence on stability, bioavailability and the process by which the dosage forms are prepared. Classification of Tablet excipients Diluent Disintegrant Binder Glidant Lubricant Antiadherent Flavor Color Example of substances Type of Excipient Filler:-Lactose, Sucrose, Glucose, Mannitol, Sorbitol, Calcium phosphate, Calcium carbonate, Cellulose Disintegrant: Starch, Cellulose, Crosslinked polyvinyl pyrrolidine, Sodium starch glycolate, Sodium CMC Solution Binder: Gelatin, Polyvinyl pyrrolidine, Cellulose derivatives (hydroxypropylmethyl cellulose, Sucrose, Starch Dry Binder Cellulose, Methylcellulose, Polyvinyl pyrrolidine, Polyethylene glycol Glidant: Silica, Magnesium stearate, Talc Lubricant :Magnesium stearate, Stearic acid, Polyethylene glycol, Liquid Paraffin Criteria for selection of excipients Regardless of why an excipient is selected, they must meet certain criteria in the formulation. These include the following: 1.They must be nontoxic & acceptable to the regulatory agencies in all countries where the product is to be marketed. 2. They must be commercially available in an acceptable grade in all countries where the product is to be manufactured. 3. Their cost must be acceptably low. 4. They must be physiologically inert. Criteria for selection of excipients 5. They must be physically and chemically stable by themselves and in combination with the drug(s) and other tablet components.
6. They must be color-compatible (not produce any off-color