Scribd Logo
Upload

Welcome to Scribd!

  • Imunologi Tumor

    Uploaded by

    taufik.abdi
    44 views13 pages
    - Mutations can cause loss of cell adhesion molecules, dysregulation of growth factor receptors and signaling pathways, and overexpression of matrix proteases, leading to neoplastic cells with uncontrolled growth and hyperproliferation. - Neoplastic cells can form benign tumors that are genetically unstable or malignant tumors that metastasize. - Theories of cancer origins include viruses, immune system failures in immune surveillance, and the accumulation of two or more genetic "hits" as proposed by Knudson's theory of carcinogenesis.

    Original Description:

    imunologi tumor

    Copyright

    © © All Rights Reserved

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    - Mutations can cause loss of cell adhesion molecules, dysregulation of growth factor receptors and signaling pathways, and overexpression of matrix proteases, leading to neoplastic cells with uncontrolled growth and hyperproliferation. - Neoplastic cells can form benign tumors that are genetically unstable or malignant tumors that metastasize. - Theories of cancer origins include viruses, immune system failures in immune surveillance, and the accumulation of two or more genetic "hits" as proposed by Knudson's theory of carcinogenesis.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pptx, pdf, or txt
    44 views13 pages

    Imunologi Tumor

    Uploaded by

    taufik.abdi
    - Mutations can cause loss of cell adhesion molecules, dysregulation of growth factor receptors and signaling pathways, and overexpression of matrix proteases, leading to neoplastic cells with uncontrolled growth and hyperproliferation. - Neoplastic cells can form benign tumors that are genetically unstable or malignant tumors that metastasize. - Theories of cancer origins include viruses, immune system failures in immune surveillance, and the accumulation of two or more genetic "hits" as proposed by Knudson's theory of carcinogenesis.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pptx, pdf, or txt
    of 13

    Pembimbing : Prof. Dr. dr.

    Ratna Akbari Ganie, SpPK-KH

    dr. Malayana Rahmita Nst


    Pendahuluan

    Mutasi : Mutasi : - Kehilangan CAM


    - Reseptor faktor - Siklus sel - Produksi matiks
    pertumbuhan regulator protease
    - Protein Kinase - Mutasi tambahan berlebihan

    Sel Normal Mutan, sel Tumor jinak Tumor


    neoplastik (tidak stabil ganas
    (disregulasi secara (metastasis)
    pertumbuhan, genetik)
    hiperproliferatif
    Origin of Neoplasia
     Viral (Rous sarcoma, 1908; shope papilloma,
    1933; Bittner milk factor, 1953)

     Immunologic theories (Ehrlich, 1908; immune


    surveillance, Burnet, 1950s)
    Two types of Origin :
    Monoclonal Origin : affects a single cell (B
    cell Lymphoma)
    Field Origin : affects a large number of
    similar cells (breast cancer)

     Knudson : carcinogenesis requires two


    hits; initiation (carcinogen) & promotion
    (several time).
    Monoclonal Origin
    Field Origin
    Knudson carsinogenesis
    Virogene Oncogene
    Theory
    Immune Surveilance
     Neoplastic changes frequently occur in the cells
    of the body
     As a result of alteration in their DNA, neoplastic
    cells produce new molecule
     The immune system recognizes these
    neoantigens as foreign and mounts a cytotoxic
    immune response that destroys the neoplastic
    cells.
     Neoplastic cells produce clinically detectable
    neoplasm only if they escape recognition and
    destruction by the immune system.
    Respon Imun Terhadap Tumor
    TERIMA KASIH

    You might also like