Pharmacology of CVS: SCTL

PHAR 2432

Group 3E:

WONG CHUO PING 1708-8175

NUR ATIQAH BINTI RAMZAN 1708-8181
NAVIIN A/L GANAS 1708-8144
MUHAMMAD KHAIRUL AIMAN BIN MAHAMUD 1708-8185
Describe the structure & function of a
nephron including its vascular supply
Structure of a nephron
Nephrons are the structural and functional units that form urine
•Each nephron consists of:
–Renal corpuscle, made up of
•Glomerulus
•Bowman’s (glomerular) capsule
–Renal tubule, made up of:
•Proximal convolated tubule
•Loop of Henle
–The ascending loop
–The descending loop
•Distal convoluted tubule
•Collecting duct
Nephron’s Blood Supply
Discuss carbonate anhydrase mediated
HCO3- absorption at the proximal tubule.
Carbonic anhydrase
Explain the transport of Na+ and other
ions at the thick ascending limb of
Henle’s loop via the Na-K-2Cl symport
and the role of Na-K-ATPase pump.
Explain the transport of Na+ and other ions at the
distal convoluted tubule via the Na-Cl symport.

• Impermeability of water
• Aldosterone involvement.
• NaCl reabsorption.
• Ca2+ and Mg2+ are not driven
out of the tubular lumen
• Ca2+ absorption.
Explain the transport of Na+ and other ions at the late
distal tubule and collecting duct and the role of aldosterone
and vasopressin.
Based on the handling of K+ and H+
by the late distal tubule and
collecting duct , discuss how a
diuretic that inhibits the Na-K-2Cl or
NaCl symport can cause
hypokalemia and alkalosis
Potassium Chloride
channel channel
 References
• Eaton, Pooler (2009). Vander’s Renal Physiology,
McGraw-Hill Medical, 222 pages.
• Danziger, Zeidel, Parker (2012). Renal Physiology
A Clinical Approach, Lippincott William & Wilkins,
218 pages.
• Koeppen, Stanton (2013). Renal Physiology,
Elsevier Inc., 225 pages
• Katzung pg 254-259
• Rang and Dale pg 347-352
• https://opentextbc.ca/anatomyandphysiology/ch
apter/25-6-tubular-reabsorption/
• https://www.cvpharmacology.com/diuretic/diure
tics